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公开(公告)号：US09581590B2
公开(公告)日：2017-02-28
申请号：US13670630
申请日：2012-11-07
IPC分类号： B82Y30/00 , G01N33/543 , B22F9/16 , C12Q1/68 , G01N33/569 , C23C18/44
CPC分类号： G01N33/54326 , B22F9/16 , C12Q1/6825 , C23C18/44 , G01N33/5434 , G01N33/54346 , G01N33/56911
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
摘要翻译： 本公开涉及金属纳米颗粒组合物及其形成和使用方法，特别是金纳米颗粒（AuNP）和金涂覆的磁性纳米颗粒。 根据本公开的组合物包括用一种或多种碳水化合物封端剂稳定的金属纳米颗粒和/或用一个或多个结合对成员进行功能化以捕获/检测靶分析物的水悬浮液。 纳米颗粒悬浮液在较长时间内是稳定的，并且可以在随后的时间点根据需要进行功能化，通常在用于检测靶生物分析物的测定之前。 稳定的纳米颗粒悬浮液可以通过在诸如糊精或其它寡糖的碳水化合物基封端剂存在下，在非酸性pH值下，通过氧化金属前体的水还原形成。
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公开(公告)号：US11221330B2
公开(公告)日：2022-01-11
申请号：US16273722
申请日：2019-02-12
IPC分类号： G01N33/543 , B22F9/16 , C12Q1/6825 , G01N33/569 , C23C18/44
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
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公开(公告)号：US20200371094A1
公开(公告)日：2020-11-26
申请号：US16990056
申请日：2020-08-11
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY , USA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF USAMRMC
IPC分类号： G01N33/543 , G01N27/327 , G01N33/569
摘要： The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.
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公开(公告)号：US20140024026A1
公开(公告)日：2014-01-23
申请号：US13670630
申请日：2012-11-07
IPC分类号： C12Q1/68 , G01N33/569 , B22F9/16
CPC分类号： G01N33/54326 , B22F9/16 , C12Q1/6825 , C23C18/44 , G01N33/5434 , G01N33/54346 , G01N33/56911
摘要： The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides.
摘要翻译： 本公开涉及金属纳米颗粒组合物及其形成和使用方法，特别是金纳米颗粒（AuNP）和金涂覆的磁性纳米颗粒。 根据本公开的组合物包括用一种或多种碳水化合物封端剂稳定的金属纳米颗粒和/或用一个或多个结合对成员进行功能化以捕获/检测靶分析物的水悬浮液。 纳米颗粒悬浮液在较长时间内是稳定的，并且可以在随后的时间点根据需要进行功能化，通常在用于检测靶生物分析物的测定之前。 稳定的纳米颗粒悬浮液可以通过在诸如糊精或其它寡糖的碳水化合物基封端剂存在下，在非酸性pH值下，通过氧化金属前体的水还原形成。
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