-
公开(公告)号：US07691888B2
公开(公告)日：2010-04-06
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , A61K31/4162 , C07D513/02 , C07D417/14
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
-
公开(公告)号：US08207349B2
公开(公告)日：2012-06-26
申请号：US12685213
申请日：2010-01-11
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： C07D277/60
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
-
公开(公告)号：US20060100254A1
公开(公告)日：2006-05-11
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , C07D513/02
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3定义如权利要求1，其适用于治疗以下特征的疾病： 过度或异常细胞增殖，以及它们用于制备具有上述性质的药物。
-
公开(公告)号：US07902183B2
公开(公告)日：2011-03-08
申请号：US11696892
申请日：2007-04-05
申请人： Steffen Steurer , Bodo Betzemeier , Darryl McConnell , Thomas Gerstberger , Matthias Grauert , Matthias Hoffmann , Maria Impagnatiello , Lars van der Veen , Ulrike Weyer-Czernilofsky
发明人： Steffen Steurer , Bodo Betzemeier , Darryl McConnell , Thomas Gerstberger , Matthias Grauert , Matthias Hoffmann , Maria Impagnatiello , Lars van der Veen , Ulrike Weyer-Czernilofsky
IPC分类号： A61K31/43 , A61K31/497 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 5如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物的药物的用途， 上述属性。
-
公开(公告)号：US07517995B2
公开(公告)日：2009-04-14
申请号：US11690356
申请日：2007-03-23
申请人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： C07D513/04
摘要： Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1，R 2，R a和R b具有权利要求书和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映异构体及其混合物，以及任选的药理学可接受的酸加成 盐，溶剂合物和水合物，以及制备这些噻唑基 - 二氢环戊吡唑的方法及其作为药物组合物的用途。
-
公开(公告)号：US20070259855A1
公开(公告)日：2007-11-08
申请号：US11690360
申请日：2007-03-23
申请人： Udo Maier , Matthias Grauert , Matthias Hoffmann , Christoph Hoenke , Anne Joergensen , Alexander Pautsch , Trixi Brandl , Steffen Breitfelder , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Udo Maier , Matthias Grauert , Matthias Hoffmann , Christoph Hoenke , Anne Joergensen , Alexander Pautsch , Trixi Brandl , Steffen Breitfelder , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/429 , A61K31/428 , A61K31/44 , A61K31/517 , A61K31/549 , A61K31/55 , A61K31/551 , A61P11/00 , A61P17/00 , A61P19/00 , A61P29/00 , A61P31/00 , A61P37/00 , C07D417/06 , C07D513/04
CPC分类号： C07D513/04
摘要： Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1，R 2，R a和R b， SUP>具有权利要求书和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映体及其混合物，以及任选的药理学上可接受的酸加成盐，溶剂合物和水合物，以及制备这些噻唑基 - 二氢 - 吲唑的方法和 其作为药物组合物的用途。
-
7.发明授权公开(公告)号：US08334378B2
公开(公告)日：2012-12-18
申请号：US12706936
申请日：2010-02-17
申请人： Trixi Brandl , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Steffen Breitfelder , Matthias Grauert , Christoph Hoenke , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Trixi Brandl , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Steffen Breitfelder , Matthias Grauert , Christoph Hoenke , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： C07D417/14 , C07D413/14 , C07D513/04
CPC分类号： C07D513/04
摘要： Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的噻唑基 - 二氢 - 喹唑啉，其中基团R 1至R 4具有权利要求书和说明书中给出的含义，其异构体，以及这些化合物的制备方法及其作为药物组合物的用途。
-
公开(公告)号：US07691868B2
公开(公告)日：2010-04-06
申请号：US11690362
申请日：2007-03-23
申请人： Trixi Brandl , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Steffen Breitfelder , Matthias Grauert , Christoph Hoenke , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Trixi Brandl , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Steffen Breitfelder , Matthias Grauert , Christoph Hoenke , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D513/04
摘要： Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的噻唑基 - 二氢 - 喹唑啉，其中基团R 1至R 4具有权利要求书和说明书中给出的含义，其异构体，以及这些化合物的制备方法及其作为药物组合物的用途。
-
公开(公告)号：US20090093474A1
公开(公告)日：2009-04-09
申请号：US12277543
申请日：2008-11-25
申请人： Matthias Grauert , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Christoph Hoenke , Steffen Breitfelder , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Matthias Grauert , Udo Maier , Matthias Hoffmann , Stefan Scheuerer , Anne T. Joergensen , Alexander Pautsch , Trixi Brandl , Christoph Hoenke , Steffen Breitfelder , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/429 , A61K31/454
CPC分类号： C07D513/04
摘要： The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I) wherein the groups R1, R2 and R3 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的噻唑基 - 二氢 - 吲唑，其中基团R 1，R 2和R 3具有权利要求和说明书中给出的含义，互变异构体，外消旋体，对映体，非对映异构体及其混合物， 其药理学上可接受的酸加成盐，溶剂化物和水合物，以及制备这些噻唑基 - 二氢 - 吲唑的方法及其作为药物组合物的用途。
-
公开(公告)号：US20070238730A1
公开(公告)日：2007-10-11
申请号：US11690356
申请日：2007-03-23
申请人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
发明人： Steffen Breitfelder , Udo Maier , Christoph Hoenke , Anne Joergensen , Alexander Pautsch , Trixi Brandl , Matthias Grauert , Matthias Hoffmann , Stefan Scheuerer , Klaus Erb , Michael Pieper , Ingo Pragst
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/43 , C07D498/02
CPC分类号： C07D513/04
摘要： Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的化合物，其中基团R 1，R 2，R a和R b， SUP>具有权利要求书和说明书中给出的含义，互变异构体，外消旋物，对映异构体，非对映异构体及其混合物，以及任选的药理学上可接受的酸加成盐，溶剂合物和水合物，以及制备这些噻唑基 - 二氢环戊吡唑和 其作为药物组合物的用途。
-
-
-
-
-
-
-
-
-
搜索结果
108 条记录 (耗时 0.074 秒)
