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公开(公告)号：US07902183B2
公开(公告)日：2011-03-08
申请号：US11696892
申请日：2007-04-05
申请人： Steffen Steurer , Bodo Betzemeier , Darryl McConnell , Thomas Gerstberger , Matthias Grauert , Matthias Hoffmann , Maria Impagnatiello , Lars van der Veen , Ulrike Weyer-Czernilofsky
发明人： Steffen Steurer , Bodo Betzemeier , Darryl McConnell , Thomas Gerstberger , Matthias Grauert , Matthias Hoffmann , Maria Impagnatiello , Lars van der Veen , Ulrike Weyer-Czernilofsky
IPC分类号： A61K31/43 , A61K31/497 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 5如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物的药物的用途， 上述属性。
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公开(公告)号：US07691888B2
公开(公告)日：2010-04-06
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , A61K31/4162 , C07D513/02 , C07D417/14
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
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公开(公告)号：US08207349B2
公开(公告)日：2012-06-26
申请号：US12685213
申请日：2010-01-11
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： C07D277/60
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述 属性。
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公开(公告)号：US20060100254A1
公开(公告)日：2006-05-11
申请号：US11243796
申请日：2005-10-05
申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel
IPC分类号： A61K31/429 , C07D513/02
CPC分类号： C07D513/04 , C07D277/84
摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in Claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3定义如权利要求1，其适用于治疗以下特征的疾病： 过度或异常细胞增殖，以及它们用于制备具有上述性质的药物。
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公开(公告)号：US07893049B2
公开(公告)日：2011-02-22
申请号：US11696900
申请日：2007-04-05
申请人： Darryl McConnell , Bodo Betzemeier , Thomas Gerstberger , Maria Impagnatiello , Steffen Steurer , Lars van der Veen , Ulrike Weyer-Czernilofsky
发明人： Darryl McConnell , Bodo Betzemeier , Thomas Gerstberger , Maria Impagnatiello , Steffen Steurer , Lars van der Veen , Ulrike Weyer-Czernilofsky
IPC分类号： A61K31/00 , A61K31/44 , A61K31/445 , A61K31/497 , A61P43/00 , C07D211/32 , C07D217/00 , C07D279/10 , C07D401/00 , C07D413/00
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R6 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 6如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物的药物的用途， 上述属性。
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公开(公告)号：US20070088051A1
公开(公告)日：2007-04-19
申请号：US11558953
申请日：2006-11-13
申请人： Darryl McConnell , Ulrike Weyer-Czernilofsky , Maria Impagnatiello , Steffen Steurer , Ralph Brueckner , Bernd Krist , Bodo Betzemeier , Frank Hilberg , Armin Heckel , Gerald Roth , Joerg Kley , Thorsten Lehmann-Lintz
发明人： Darryl McConnell , Ulrike Weyer-Czernilofsky , Maria Impagnatiello , Steffen Steurer , Ralph Brueckner , Bernd Krist , Bodo Betzemeier , Frank Hilberg , Armin Heckel , Gerald Roth , Joerg Kley , Thorsten Lehmann-Lintz
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/421 , A61K31/423 , A61K31/422 , A61K31/416 , A61K31/404 , C07D413/02 , C07D403/02
CPC分类号： C07D409/04 , C07D209/34 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/10 , C07D413/04
摘要： The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
摘要翻译： 本发明涉及式（I）的吲哚满酮化合物，其中Y和R 1至R 8定义如权利要求1，其适用于治疗特征性疾病 通过过度或异常的细胞增殖及其用于制备药物组合物的用途。
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公开(公告)号：US20060135592A1
公开(公告)日：2006-06-22
申请号：US11303168
申请日：2005-12-16
申请人： Darryl McConnell , Ulrike Weyer-Czernilofsky , Maria Impagnatiello , Steffen Steurer , Ralph Brueckner , Bernd Krist , Bodo Betzemeier , Frank Hilberg , Armin Heckel , Gerald Roth , Joerg Kley , Thorsten Lehmann-Lintz
发明人： Darryl McConnell , Ulrike Weyer-Czernilofsky , Maria Impagnatiello , Steffen Steurer , Ralph Brueckner , Bernd Krist , Bodo Betzemeier , Frank Hilberg , Armin Heckel , Gerald Roth , Joerg Kley , Thorsten Lehmann-Lintz
IPC分类号： A61K31/404 , C07D209/02 , C07D403/02
CPC分类号： C07D409/04 , C07D209/34 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/10 , C07D413/04
摘要： The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
摘要翻译： 本发明涉及式（I）的吲哚满酮化合物，其中Y和R 1至R 8定义如权利要求1，其适用于治疗特征性疾病 通过过度或异常的细胞增殖及其用于制备药物组合物的用途。
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8.发明申请2,4-DIAMINOPYRIMIDINE DERIVATES AS PTK2- INHIBITORS FOR THE TREATMENT OF ABNORMAL CELL GROWTH 有权2,4-二氨基嘧啶衍生物作为治疗异常细胞生长的PTK2-抑制剂公开(公告)号：US20110275633A1
公开(公告)日：2011-11-10
申请号：US13128029
申请日：2009-11-13
IPC分类号： A61K31/506 , C07D413/12 , C07D403/12 , C07D407/14 , A61P37/00 , A61K31/5377 , A61K31/496 , A61P35/00 , A61P29/00 , C07D401/12 , C07D413/14
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1-R3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R1-R3和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备具有上述药物的用途 提到的属性。
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公开(公告)号：US20110288109A1
公开(公告)日：2011-11-24
申请号：US13130069
申请日：2009-11-24
IPC分类号： A61K31/506 , C07D401/14 , C07D417/14 , C07D403/12 , A61P37/06 , C07D413/14 , A61P35/00 , A61P31/00 , A61P29/00 , C07D401/12 , C07D405/14
CPC分类号： C07D417/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： The present invention includes compounds of general Formula (1), wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，R 1和R 2如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物 具有上述性质。
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公开(公告)号：US20100222331A1
公开(公告)日：2010-09-02
申请号：US12664162
申请日：2008-06-09
申请人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
发明人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
IPC分类号： A61K31/551 , C07D403/04 , A61K31/517 , C07D413/14 , A61K31/536 , C07D403/14 , A61K31/4184 , A61K31/5377 , C07D417/14 , A61K31/5415 , A61P29/00 , A61P31/00 , A61P37/00 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2，R 3，Q，W，X，Y和Z如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 其用途是制备具有上述性质的药物。
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