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公开(公告)号：US20150284462A1
公开(公告)日：2015-10-08
申请号：US14742836
申请日：2015-06-18
发明人： Renate KONOPITZKY , Eric BORGES , Paul ADAM , Karl-Heinz HEIDER
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
摘要翻译： 本发明涉及基于骨髓细胞消耗的免疫疗法。 特别地，本发明涉及用于此类疗法的CD33结合剂，例如， 治疗骨髓细胞恶性肿瘤和骨髓增生异常综合征（MDS）。
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公开(公告)号：US20210107983A1
公开(公告)日：2021-04-15
申请号：US17060111
申请日：2020-10-01
发明人： Susanne HIPP , Paul ADAM , Michael DZIEGELEWSKI , Rajkumar GANESAN , Philip Nicholas GORMAN , Pankaj GUPTA , Priyanka GUPTA , Marcio LASARO , Justin M. SCHEER , Vladimir M. VOYNOV
摘要： The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.
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公开(公告)号：US20190256593A1
公开(公告)日：2019-08-22
申请号：US16221811
申请日：2018-12-17
发明人： Renate KONOPITZKY , Eric BORGES , Paul ADAM , Karl-Heinz HEIDER
IPC分类号： C07K16/28
摘要： The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
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公开(公告)号：US20220411533A1
公开(公告)日：2022-12-29
申请号：US17840655
申请日：2022-06-15
发明人： Paul ADAM , Stephen R. COMEAU , Philip Nicholas GORMAN , Pankaj Gupta , Priyanka GUPTA , Karl-Heinz HEIDER , Srinath KASTURIRANGAN , Renate KONOPITZKY , Klaus-Peter KUENKELE , Sandeep KUMAR , Taneisha Ann-Tanara MACK , Elinborg Katrin OSTERMANN , Abdulsalam SHAABAN , David WEISMANN , Andreas WERNITZNIG , David S. YOUNG
摘要： The present invention relates to novel tri-specific binding molecules. The invention also relates to nucleic acids encoding such binding molecules; to methods for preparing such binding molecules; to host cells expressing or capable of expressing such binding molecules; to compositions comprising such binding molecules; and to uses of such binding molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.
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公开(公告)号：US20190225681A1
公开(公告)日：2019-07-25
申请号：US16210334
申请日：2018-12-05
IPC分类号： C07K16/22 , A61K31/517 , A61K39/395 , A61K31/282 , A61K45/06 , A61K31/436 , G01N33/574 , A61K33/24
摘要： Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
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公开(公告)号：US20130230541A1
公开(公告)日：2013-09-05
申请号：US13653843
申请日：2012-10-17
发明人： Paul ADAM , Eric BORGES
IPC分类号： C07K16/22 , A61K45/06 , A61K33/24 , A61K39/395 , A61K31/282
CPC分类号： C07K16/22 , A61K31/282 , A61K31/436 , A61K31/517 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57496 , G01N2333/475 , G01N2800/52 , Y02A50/466 , A61K2300/00
摘要： Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
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公开(公告)号：US20240033336A1
公开(公告)日：2024-02-01
申请号：US18184000
申请日：2023-03-15
发明人： Elodie BELNOUE , Madiha DEROUAZI , Paul ADAM , Imgard Rita Maria HOFMANN , Ralf LEONHARDT , Samuel LUKOWSKI , Tobias NOLDEN , Francesca TRAPANI
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： A61K39/001164 , A61K39/001162 , A61K39/0011 , A61K39/4611 , A61K39/4632 , A61K39/4631 , A61K39/001182 , A61K39/001154 , A61K39/464464 , A61K39/464462 , A61K39/4644 , A61K39/3955 , A61P35/00 , A61K2039/5154 , A61K2039/53 , A61K2039/70 , A61K2039/5256 , A61K2039/54
摘要： The present invention relates to tumor antigens encoded in a 5′-upstream open reading frame (uORF) within the 5′ UTR of different mRNAs. Compositions and peptides comprising such tumor antigens and a virus encoding such tumor antigens are provided. The present invention also relates to the use of such compositions, peptides and viruses in the treatment of cancer.
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公开(公告)号：US20230340130A1
公开(公告)日：2023-10-26
申请号：US18337693
申请日：2023-06-20
发明人： Susanne HIPP , Paul ADAM , Michael DZIEGELEWSKI , Rajukumar GANESAN , Phillip Nicholas GORMAN , Pankaj GUPTA , Priyanka GUPTA , Marcio LASARO , Justin M. SCHEER , Vladimir H. VOYNOV
CPC分类号： C07K16/2827 , A61P35/00 , C07K16/2809 , C07K2317/31 , C07K2317/565
摘要： The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.
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公开(公告)号：US20230295337A1
公开(公告)日：2023-09-21
申请号：US18327456
申请日：2023-06-01
发明人： Susanne HIPP , Paul ADAM , Michael DZIEGELEWSKI , Rajkumar GANESAN , Philip Nicholas GORMAN , Pankaj GUPTA , Priyanka GUPTA , Justin SCHEER , Vladimir H. VOYNOV
IPC分类号： C07K16/30 , A61P35/00 , C07K1/14 , C07K16/28 , G01N33/577 , C07K16/22 , A61K39/395 , C12N5/10 , C12N15/63
CPC分类号： C07K16/30 , A61P35/00 , C07K1/14 , C07K16/2809 , G01N33/577 , C07K16/22 , A61K39/3955 , C12N5/10 , C12N15/63 , A61K45/06
摘要： The present invention relates to novel DLL3/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.
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公开(公告)号：US20170088617A1
公开(公告)日：2017-03-30
申请号：US15375313
申请日：2016-12-12
发明人： Renate KONOPITZKY , Eric BORGES , Paul ADAM , Karl-Heinz HEIDER
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
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