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公开(公告)号：US20240408394A1
公开(公告)日：2024-12-12
申请号：US18807019
申请日：2024-08-16
Inventor： Que T. Doan , Jianwen Gu , Ismael Huertas Fernandez , Rosana Esteller , Michael A. Moffitt
Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.
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公开(公告)号：US20220387808A1
公开(公告)日：2022-12-08
申请号：US17663503
申请日：2022-05-16
Inventor： Ismael Huertas Fernandez , Que T. Doan
Abstract: Systems and methods are disclosed to permit a patient to use his external controller to move the location of stimulation in an implantable stimulator system. The external controller can be programmed with a steering algorithm, which prompts the patient to enter certain data regarding their symptoms (e.g., pain), such as pain scores and stimulation coverage. Such data is preferably entered for a plurality of different regions of the patient's body. The algorithm can compute for each body regions a targeting precision value (TP), and from these values determine a steering vector D that suggests a direction and/or a magnitude that stimulation can be moved in the electrode array to more precisely target the patient's pain. The patient may then move the location of the stimulation in accordance with the steering vector using their external controller. The algorithm can be repeated if necessary to again move the stimulation.
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公开(公告)号：US11298538B2
公开(公告)日：2022-04-12
申请号：US16454864
申请日：2019-06-27
Inventor： Ismael Huertas Fernandez , Que T. Doan
Abstract: A system may include at least one sensor configured to bilaterally sense neurophysiological signals from the patient to provide bilateral sensing data, and at least one processor configured to calibrate at least a first electrode contact and a second electrode contact on the least one neuromodulation lead, including: instruct the neuromodulation device to deliver neuromodulation energy using at least the first electrode contact to cause a first neurophysiological response and at least the second electrode contact to cause a second neurophysiological response; receive from the at least one sensor first bilateral sensed data corresponding to the first neurophysiological response and second bilateral sensed data corresponding to the second neurophysiological response; and determine based on the first and second neurophysiological responses at least one of: physiological midline information or electrode-tissue coupling information.
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公开(公告)号：US11285323B2
公开(公告)日：2022-03-29
申请号：US17328634
申请日：2021-05-24
Inventor： Que T. Doan , Jianwen Gu , Ismael Huertas Fernandez , Rosana Esteller , Michael A. Moffitt
Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.
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5.发明公开公开(公告)号：US20240245920A1
公开(公告)日：2024-07-25
申请号：US18596357
申请日：2024-03-05
Inventor： Ismael Huertas Fernandez , Que T. Doan , Michael A. Moffitt , Changfang Zhu
CPC classification number: A61N1/372 , A61N1/36071 , A61N1/3616 , A61N1/36142
Abstract: Methods for determining stimulation for a patient having a stimulator device are disclosed. A model is received at an external system indicative of a range or volume of preferred stimulation parameters, which model is preferably specific to and determined for the patient. The external system receives a plurality of pieces of fitting information for the patient, including information indicative of a symptom of the patient, information indicative of stimulation provided by the stimulator device during a fitting procedure, and/or phenotype information for the patient. The external system determines one or more sets of stimulation parameters for the patient using the pieces of fitting information. In one example, training data is applied to the pieces of fitting information to select the one or more sets of stimulation parameters from the range or volume of preferred stimulation parameters in the model.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240226558A1
公开(公告)日：2024-07-11
申请号：US18612591
申请日：2024-03-21
Inventor： Que T. Doan , Jianwen Gu , Ismael Huertas Fernandez , Rosana Esteller , Michael A. Moffitt
CPC classification number: A61N1/36062 , A61N1/0551 , A61N1/36021 , A61N1/36071 , A61N1/36185 , A61N1/37247 , A61N1/06 , A61N1/36132 , A61N1/37235 , A61N1/37252
Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.
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公开(公告)号：US11844947B2
公开(公告)日：2023-12-19
申请号：US16741196
申请日：2020-01-13
Inventor： Que T. Doan , Luca Antonello Annecchino , Ismael Huertas Fernandez
CPC classification number: A61N1/36175 , A61N1/025 , A61N1/36062 , A61N1/36185
Abstract: New waveforms for use in an implantable pulse generator or external trial stimulator are disclosed which mimic actively-driven biphasic pulses, and which are particularly useful for issuing low frequencies pulses. The waveforms comprise at each electrode interleaved first and second pulses. Each first pulse comprises a first monophasic pulse and a first passive charge recovery period. Each second pulse comprises a second monophasic pulse with a polarity opposite the first monophasic pulse and a second passive charge recovery period. Preferably, the amplitudes and pulse widths of the first and second monophasic pulses are equal, or at least charge balanced at each electrode. The first and second monophasic pulses mimic the functionality of a symmetric biphasic pulse, with the first monophasic pulse mimicking the functionality of the biphasic pulse's first phase, and the with the second monophasic pulse mimicking the functionality of the biphasic pulse's second phase.
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公开(公告)号：US20230355979A1
公开(公告)日：2023-11-09
申请号：US18144704
申请日：2023-05-08
Inventor： Ismael Huertas Fernandez , Que T. Doan
CPC classification number: A61N1/36071 , A61N1/36062 , A61N1/37247 , A61N1/36185 , A61N1/36132
Abstract: Systems and methods for controlling autonomic symptoms or side effects via spinal cord stimulation are discussed. An exemplary neuromodulation system comprises an electrostimulator to provide spinal cord stimulation (SCS) to a neural target, a user interface device to receive a user input including an autonomic symptom and affected anatomy, and a controller circuit to determine or adjust a stimulation parameter based at least on the autonomic symptoms and the affected anatomy. Spinal cord stimulation can be delivered in accordance with the determined or adjusted stimulation parameter to alleviate the autonomic symptom, or to treat or alleviate autonomic disorders.
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公开(公告)号：US20230355978A1
公开(公告)日：2023-11-09
申请号：US18298024
申请日：2023-04-10
Inventor： Ismael Huertas Fernandez , Que T. Doan
CPC classification number: A61N1/36062 , A61N1/36175 , A61N1/37247
Abstract: Systems and methods for controlling an implantable stimulator device such as a spinal cord stimulation are disclosed. Optimal stimulation parameters for the patient, which may be personalized for the patient based on test stimulation and organized as a neural dose, are subject to duty cycling in which stimulation is applied during an on duration and is turned off during an off duration. The duty cycling applied is automatically determined by and dependent on the stimulation parameters chosen, and in particular the frequency of those parameters. Further, a user interface element is provided to allow a user to automatically step thought suitable duty cycle values determined to be appropriate for the stimulation parameters. As such, the user does need not need to engage in guess work to specify individual on and off times when duty cycling is desired.
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公开(公告)号：US20230321441A1
公开(公告)日：2023-10-12
申请号：US18126731
申请日：2023-03-27
Inventor： Ismael Huertas Fernandez , Que T. Doan
IPC: A61N1/36
CPC classification number: A61N1/36132
Abstract: An example of a system for delivering neurostimulation from a stimulation device to a patient may include a programming control circuit, a sensory profiling circuit, and a stimulation control circuit. The programming control circuit may be configured to program the stimulation device for controlling delivery of the neurostimulation according to one or more stimulation waveforms and one or more stimulation fields. The sensory profiling circuit may be configured to receive information regarding painful symptoms of the patient and to determine a pain sensory profile for the patient using the received information. The stimulation control circuit may be configured to determine a recommendation for one or more spinal cord stimulation (SCS) therapies using the determined pain sensory profile and to determine the one or more stimulation waveforms and the one or more stimulation fields using the recommended one or more SCS therapies.
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