公开(公告)号：US20230355834A1

公开(公告)日：2023-11-09

申请号：US18311205

申请日：2023-05-02

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： Philip David Dorgan ,  Edward Joseph Devlin ,  Conor O’Sullivan ,  John Murphy ,  Mark Looney ,  Paul O’Farrell

IPC分类号： A61L24/08 ,  A61L24/00

CPC分类号： A61L24/08 ,  A61L24/0015 ,  A61L24/0031 ,  A61L2300/418 ,  A61L2400/04

摘要： In some aspects, the present disclosure pertains to injectable polysaccharide-based hydrogels that comprises an anionic polysaccharide, a cationic crosslinking agent and a hemostatic agent. In some aspects, the present disclosure pertains to medical devices containing such injectable polysaccharide-based hydrogels, to kits that contain such injectable polysaccharide-based hydrogels, and to methods of using such injectable polysaccharide-based hydrogels.

公开(公告)号：US20240315984A1

公开(公告)日：2024-09-26

申请号：US18612755

申请日：2024-03-21

申请人： Boston Scientific Scimed, Inc.

发明人： Bhanu Prasanth Koppolu ,  Philip David Dorgan ,  Rhiannon Johnson ,  Steven L. Kangas ,  Nivedita Swetha Ramkumar ,  Matthew R. Dreher

IPC分类号： A61K9/51 ,  A61K45/06

CPC分类号： A61K9/5153 ,  A61K9/5123 ,  A61K45/06

摘要： The present disclosure pertains to biodegradable polymeric microspheres that comprise a biodegradable polymer and an immunotherapeutic agent selected from an inhibitor of poly ADP ribose polymerase enzyme (PARP inhibitor) and/or a Toll-like receptor (TLR) agonist wherein (a) 50% of a total amount of the immunotherapeutic agent in the biodegradable polymeric microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; (b) between 1 mg and 100 mg of immunotherapeutic agent per 1 g dry weight of microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; or (c) both (a) and (b). Other aspects of the present disclosure pertain to methods of using such microparticles and kits that contain such microparticles.

公开(公告)号：US20220313603A1

公开(公告)日：2022-10-06

申请号：US17713596

申请日：2022-04-05

申请人： Boston Scientific Scimed Inc.

发明人： Viktoria Molnar ,  Carolina Villarreal ,  Bhanu Prasanth Koppolu ,  Nivedita Swetha Ramkumar ,  Philip David Dorgan

IPC分类号： A61K9/06 ,  A61K47/36 ,  A61K47/42 ,  A61K47/02

摘要： The present disclosure pertains to therapeutic hydrogels that comprise an anionic polysaccharide crosslinked by a branched polyamine, wherein the branched polyamine comprises at least two primary amine groups, more typically at least three primary amine groups. The present disclosure also pertains to medical compositions that comprise such therapeutic hydrogels and to methods of medical treatment in which such therapeutic hydrogels are delivered to a patient in need of medical treatment.