Abstract:
A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.
Abstract:
An imaging contrast composition comprising an iodinated contrast agent and a ligand secured to the iodinated contrast agent is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing iodinated radiocontrast agents from a patient is disclosed, the method comprising providing an iodinated radiocontrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the iodinated radiocontrast agent to the patient; conducting procedure CT scan or procedure using fluoroscopy; and sequestering the iodinated radiocontrast agent on the capture substrate.
Abstract:
A balloon catheter visualization system for repairing a heart valve in a patent includes one or more elongate shafts, each shaft defining at least one lumen and comprising a distal end portion and a proximal end portion. The system also includes a transparent balloon member coupled to the one or more elongate shafts and is in fluid communication with at least one lumen of the one or more elongate shafts. The system also includes an imaging element disposed within the balloon member and coupled to a distal end portion of the one or more elongate shafts, a fastener releasably coupled to a distal end portion of the one or more elongate shafts, and a connector coupled to a distal end portion of the one or more elongate shafts. The connector is adapted to fasten the fastener to tissue.