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公开(公告)号：US11213596B2
公开(公告)日：2022-01-04
申请号：US16276174
申请日：2019-02-14
发明人： Joseph Thomas Delaney, Jr. , Douglas Dean Pagoria , Richard Lee Tadsen , Andrew J. Ro , Joel T. Eggert , Douglas Pennington , Paul Sorajja , Sarah Melissa Gruba , Tatyana Dyndikova
摘要： An imaging contrast composition comprising an iodinated contrast agent and a ligand secured to the iodinated contrast agent is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing iodinated radiocontrast agents from a patient is disclosed, the method comprising providing an iodinated radiocontrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the iodinated radiocontrast agent to the patient; conducting procedure CT scan or procedure using fluoroscopy; and sequestering the iodinated radiocontrast agent on the capture substrate.
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2.发明公开公开(公告)号：US20240342346A1
公开(公告)日：2024-10-17
申请号：US18633245
申请日：2024-04-11
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61M2025/105
摘要： A medical device may be coated with a therapeutic composition that includes everolimus. Everolimus crystals may be coated with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition. An illustrative coating composition may comprise a mixture of excipients including a bioresorbable or thermo-gelling polymer and a plasticizing agent and a therapeutic agent. The bioresorbable or thermo-gelling polymer may be selected from polycaprolactone (PCL) or poloxamer.
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公开(公告)号：US20190275178A1
公开(公告)日：2019-09-12
申请号：US16276174
申请日：2019-02-14
发明人： Joseph Thomas Delaney , Douglas Dean Pagoria , Richard Lee Tadsen , Andrew J. Ro , Joel T. Eggert , Douglas Pennington , Paul Sorajja , Sarah Melissa Gruba , Tatyana Dyndikova
IPC分类号： A61K49/04
摘要： An imaging contrast composition comprising an iodinated contrast agent and a ligand secured to the iodinated contrast agent is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing iodinated radiocontrast agents from a patient is disclosed, the method comprising providing an iodinated radiocontrast agent containing a reactive group; providing a capture substrate for insertion into a patient's bloodstream; administering the iodinated radiocontrast agent to the patient; conducting procedure CT scan or procedure using fluoroscopy; and sequestering the iodinated radiocontrast agent on the capture substrate.
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公开(公告)号：US20180303972A1
公开(公告)日：2018-10-25
申请号：US15959894
申请日：2018-04-23
发明人： Joseph Thomas Delaney, JR. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
CPC分类号： A61L27/16 , A61L27/48 , A61L2430/20 , C08J3/246 , C08J2323/22 , C08J2337/00 , C08J2479/02 , C08L53/00 , C08L2203/02 , C08L23/22
摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US20220249676A1
公开(公告)日：2022-08-11
申请号：US17616576
申请日：2020-05-11
发明人： Joseph Thomas Delaney, JR. , Sarah Melissa Gruba , Tatyana Dyndikova , Paul Vincent Grosso , Amanda Maxwell , Ajay Gupta , Andrew J. Ro , Douglas Pennington
摘要： A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.
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公开(公告)号：US20210170069A1
公开(公告)日：2021-06-10
申请号：US17179971
申请日：2021-02-19
发明人： Joseph Thomas Delaney, JR. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US10925998B2
公开(公告)日：2021-02-23
申请号：US15959894
申请日：2018-04-23
发明人： Joseph Thomas Delaney, Jr. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
IPC分类号： C08J3/24 , C08J7/04 , C08J7/056 , C08L23/18 , C08L23/22 , D01D5/08 , D01D5/18 , D02G3/36 , A61L27/16 , C08L53/00 , A61L27/48 , D01D5/00 , D01D5/098
摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US12115275B2
公开(公告)日：2024-10-15
申请号：US17179971
申请日：2021-02-19
发明人： Joseph Thomas Delaney, Jr. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
CPC分类号： A61L27/16 , A61L27/48 , C08J3/246 , C08L53/00 , D01D5/0023 , D01D5/003 , D01D5/0985 , A61L2430/20 , C08J2323/18 , C08J2323/22 , C08J2337/00 , C08J2479/02 , C08L2203/02 , D10B2509/06 , A61L27/48 , C08L23/22
摘要： Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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