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    KENNEL COUGH VACCINE
    2.
    发明申请
    KENNEL COUGH VACCINE 审中-公开

    公开(公告)号：US20100221279A1

    公开(公告)日：2010-09-02

    申请号：US12783950

    申请日：2010-05-20

    申请人： Bradley W. Fenwick

    发明人： Bradley W. Fenwick

    IPC分类号： A61K39/10 ,  A61K39/108 ,  A61P11/14 ,  A61P31/04 ,  C12N15/09

    CPC分类号： A61K39/099 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/552

    摘要： Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin vaccine), the latter including recombinant DNA encoding at least one protective protein (e.g., an antigenic protein) which has been expressed by the microorganisms prior to killing thereof. The protective protein(s) are operable to prevent or reduce the severity of a disease of the subject. The vaccine preparations of the invention do not require separation of the protective protein(s) from the host recombinant microorganism(s), thereby materially decreasing the complexity and cost of the vaccine formulations. A preferred vaccine against kennel cough includes recombinantly modified microorganisms which express protective antigens containing pertactin and filamentous hemagglutinin protein products.

    摘要翻译： 提供了用于给活体受试者（例如哺乳动物和鸟类）施用的改进的低成本疫苗，其包括杀死的重组修饰的微生物（全细胞重组菌苗疫苗），后者包括编码至少一种保护性蛋白质（例如抗原蛋白质）的重组DNA， 其在杀死之前由微生物表达。 保护性蛋白质可用于预防或降低受试者疾病的严重性。 本发明的疫苗制剂不需要将保护性蛋白质与宿主重组微生物分离，从而大大降低了疫苗制剂的复杂性和成本。 针对狗窝咳嗽的优选疫苗包括表达包含pertactin和丝状血凝素蛋白产物的保护性抗原的重组修饰的微生物。

    Swine immunization using live, RTX toxin-secreting organisms
    3.
    发明授权
    Swine immunization using live, RTX toxin-secreting organisms 失效
    使用活的RTX毒素分泌生物进行猪免疫

    公开(公告)号：US5908630A

    公开(公告)日：1999-06-01

    申请号：US541226

    申请日：1995-10-12

    申请人： Bradley W. Fenwick

    发明人： Bradley W. Fenwick

    IPC分类号： A61K39/102 ,  A61P31/04 ,  A01N37/18 ,  A61K39/02 ,  A61K39/205

    CPC分类号： A61K39/102 ,  A61K2039/522 ,  A61K2039/552 ,  Y10S424/825

    摘要： An improved method and vaccine is provided for the immunization of swine against infectious diseases caused by RTX toxin-secreting bacteria (e.g., porcine pleuropneumonia) which comprises administering to swine an effective amount of a live, immunizing, RTX toxin-secreting organism which induces in the swine a sufficiently high RTX toxin-neutralizing antibody titer to at least prevent clinical symptoms of the disease in the swine. For example, an intranasally administered, live, low virulence strain of A. suis (EM1) confers immunity upon swine against challenge with a virulent, disease-causing strain of A. pleuropneunmoniae.

    摘要翻译： 提供了一种改进的方法和疫苗，用于免疫针对由RTX毒素分泌细菌（例如猪胸膜肺炎）引起的感染性疾病的猪，其包括施用有效量的活的，免疫的RTX毒素分泌生物体，其诱导 猪具有足够高的RTX毒素中和抗体滴度以至少防止猪中该疾病的临床症状。 例如，鼻内施用的活的低毒力的猪链球菌（EM1）赋予猪免疫力以抵抗来自A. pleuropneunmonna亚种的毒性致病菌株的攻击。

    Kennel cough vaccine
    4.
    发明授权
    Kennel cough vaccine 失效
    犬舍咳嗽疫苗

    公开(公告)号：US07521059B2

    公开(公告)日：2009-04-21

    申请号：US10867532

    申请日：2004-06-14

    申请人： Bradley W. Fenwick

    发明人： Bradley W. Fenwick

    IPC分类号： A61K39/10

    CPC分类号： A61K39/099 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/552

    摘要： Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin vaccine), the latter including recombinant DNA encoding at least one protective protein (e.g., an antigenic protein) which has been expressed by the microorganisms prior to killing thereof. The protective protein(s) are operable to prevent or reduce the severity of a disease of the subject. The vaccine preparations of the invention do not require separation of the protective protein(s) from the host recombinant microorganism(s), thereby materially decreasing the complexity and cost of the vaccine formulations. A preferred vaccine against kennel cough includes recombinantly modified microorganisms which express protective antigens containing pertactin and filamentous hemagglutinin protein products.

    摘要翻译： 提供了用于给活体受试者（例如哺乳动物和鸟类）施用的改进的低成本疫苗，其包括杀死的重组修饰的微生物（全细胞重组菌苗疫苗），后者包括编码至少一种保护性蛋白质（例如抗原蛋白质）的重组DNA， 其在杀死之前由微生物表达。 保护性蛋白质可用于预防或降低受试者疾病的严重性。 本发明的疫苗制剂不需要将保护性蛋白质与宿主重组微生物分离，从而大大降低了疫苗制剂的复杂性和成本。 针对狗窝咳嗽的优选疫苗包括表达包含pertactin和丝状血凝素蛋白产物的保护性抗原的重组修饰的微生物。

    KENNEL COUGH VACCINE
    5.
    发明申请
    KENNEL COUGH VACCINE 审中-公开

    公开(公告)号：US20090074811A1

    公开(公告)日：2009-03-19

    申请号：US12273021

    申请日：2008-11-18

    申请人： Bradley W. Fenwick

    发明人： Bradley W. Fenwick

    IPC分类号： A61K39/02

    CPC分类号： A61K39/099 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/552

    摘要： Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin vaccine), the latter including recombinant DNA encoding at least one protective protein (e.g., an antigenic protein) which has been expressed by the microorganisms prior to killing thereof. The protective protein(s) are operable to prevent or reduce the severity of a disease of the subject. The vaccine preparations of the invention do not require separation of the protective protein(s) from the host recombinant microorganism(s), thereby materially decreasing the complexity and cost of the vaccine formulations. A preferred vaccine against kennel cough includes recombinantly modified microorganisms which express protective antigens containing pertactin and filamentous hemagglutinin protein products.