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    DEVICE FOR DETECTING AN ENZYME IN A SAMPLE
    3.
    发明申请
    DEVICE FOR DETECTING AN ENZYME IN A SAMPLE 审中-公开
    用于检测样品中的酶的装置

    公开(公告)号：US20090104690A1

    公开(公告)日：2009-04-23

    申请号：US11814807

    申请日：2006-01-27

    申请人： Simon W. Bayliff ,  Alicia Essler ,  David Greenhalgh ,  Maurice C. Biott

    发明人： Simon W. Bayliff ,  Alicia Essler ,  David Greenhalgh ,  Maurice C. Biott

    IPC分类号： C12M1/00

    CPC分类号： C12Q1/04 ,  C12Q1/37 ,  G01N2333/96486 ,  G01N2333/966 ,  G01N2333/968

    摘要： A device for detecting a mammalian host-derived enzyme in a sample of a wound fluid, said device comprising: a housing having an inlet for the sample and side walls defining a fluid flow path extending from said inlet an indicator moiety that is bound to a solid substrate by means of a peptide linker moiety that is cleavable by said host-derived enzyme, said solid substrate being located in a reaction zone of said fluid flow path; and a detector moiety located in a detection zone downstream from the reaction zone in said fluid flow path, wherein the detector moiety interacts with an indicator moiety that has been cleaved from said solid substrate to produce a detectable change in said detection zone. Suitably, the device further comprises a control moiety located in a control zone in said device, wherein the control moiety can interact with a component of the wound fluid sample to improve the accuracy of the device. Also provided are systems comprising a device of the invention and a swab or biopsy punch adapted for use therewith.

    摘要翻译： 一种用于检测伤口流体样品中的哺乳动物宿主衍生的酶的装置，所述装置包括：壳体，其具有用于样品的入口和侧壁，所述壳体限定从所述入口延伸的流体流动路径，所述指示器部分被结合到 通过可由所述宿主衍生的酶切割的肽接头部分的固体底物，所述固体基质位于所述流体流动路径的反应区中; 以及位于所述流体流动路径中的反应区下游的检测区域中的检测器部分，其中所述检测器部分与已经从所述固体基质切割的指示剂部分相互作用，以在所述检测区域中产生可检测的变化。 合适地，该装置还包括位于所述装置中的对照区中的对照部分，其中控制部分可与伤口流体样品的组分相互作用以提高装置的精度。 还提供了包括本发明的装置和适于与其一起使用的拭子或活检冲头的系统。