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公开(公告)号：US08118812B2
公开(公告)日：2012-02-21
申请号：US11244435
申请日：2005-10-04
CPC分类号： A61K33/42 , A61B17/8822 , A61F2002/4602 , A61F2002/4683
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供了使用骨缺损填充（例如矫形水泥）与硬组织固定装置（例如螺钉，板或杆）结合的方法。 本发明方法的特征在于，当将固定装置施加振动力时，通过固定装置的通道将水泥引入目标骨骼部位。 还提供了用于实践主题方法的系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US09707024B2
公开(公告)日：2017-07-18
申请号：US13347524
申请日：2012-01-10
CPC分类号： A61B17/8822 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
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公开(公告)号：US20120253351A1
公开(公告)日：2012-10-04
申请号：US13434669
申请日：2012-03-29
IPC分类号： A61B17/56
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。 主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后 的水泥到目标地点。 还提供了用于实践主题方法的设备，系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US08167889B2
公开(公告)日：2012-05-01
申请号：US11771603
申请日：2007-06-29
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。 主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后 的水泥到目标地点。 还提供了用于实践主题方法的设备，系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US07252833B2
公开(公告)日：2007-08-07
申请号：US10717171
申请日：2003-11-18
申请人： Brent R. Constantz , David Delaney
发明人： Brent R. Constantz , David Delaney
CPC分类号： A61L24/02
摘要： Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 提供了用于生产可流动组合物的方法和组合物，例如。 糊剂，其设置为包含破骨细胞生成剂的磷酸钙产品。 在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和破骨细胞生成剂如RANKL或其模拟物组合，并将合并的反应物混合以产生可流动组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
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公开(公告)号：US07252672B2
公开(公告)日：2007-08-07
申请号：US10797907
申请日：2004-03-09
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。 主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后 的水泥到目标地点。 还提供了用于实践主题方法的设备，系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US09833274B2
公开(公告)日：2017-12-05
申请号：US13434669
申请日：2012-03-29
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
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公开(公告)号：US20120165822A1
公开(公告)日：2012-06-28
申请号：US13347524
申请日：2012-01-10
CPC分类号： A61B17/8822 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供了使用骨缺损填充（例如矫形水泥）与硬组织固定装置（例如螺钉，板或杆）结合的方法。 本发明方法的特征在于，当将固定装置施加振动力时，通过固定装置的通道将水泥引入目标骨骼部位。 还提供了用于实践主题方法的系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US08419803B2
公开(公告)日：2013-04-16
申请号：US11189555
申请日：2005-07-25
CPC分类号： A61L27/12 , Y10S514/951 , Y10S514/955
摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译： 用于生产可流动组合物的方法和组合物，例如 提供了设置成磷酸钙产品的糊剂。 在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。 本发明方法的特征在于干燥的反应物包括平均粒径小于约8μm并且尺寸分布窄的粒状钙和/或磷酸盐反应物。 还提供了组合物本身以及用于实践本发明方法的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。
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公开(公告)号：US08771748B2
公开(公告)日：2014-07-08
申请号：US11134051
申请日：2005-05-19
CPC分类号： C04B28/344 , A61K33/42 , C04B2103/12 , C04B2111/00836 , C04B22/16 , C04B24/383 , C04B40/0641
摘要： Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 提供了用于制备组合物的方法，例如 糊剂或粘土，迅速成为高强度磷酸钙产品。 在本发明的方法中，包括钙和磷酸盐源的干燥反应物以及一价阳离子磷酸二氢盐与凝固流体混合并将组合的反应物混合以产生可固化组合物。 本发明的特征是水泥迅速地成为高强度的产品组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
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