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公开(公告)号：US20110021427A1
公开(公告)日：2011-01-27
申请号：US12843357
申请日：2010-07-26
CPC分类号： A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要： This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译： 本发明涉及结合生物聚合物载体的生物矿物基水泥，用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物。 本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。
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公开(公告)号：US08529933B2
公开(公告)日：2013-09-10
申请号：US12843357
申请日：2010-07-26
CPC分类号： A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要： This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译： 本发明涉及结合生物聚合物载体的生物矿物基水泥，用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物。 本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。
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公开(公告)号：US5626877A
公开(公告)日：1997-05-06
申请号：US193997
申请日：1994-02-09
申请人： Brian G. Amsden , Yu-Ling Cheng
发明人： Brian G. Amsden , Yu-Ling Cheng
CPC分类号： A61K38/47 , A61K38/1808 , A61K9/0004 , A61K9/2009 , A61K9/2027
摘要： Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.
摘要翻译： 本文描述了一种药物递送系统，其用于以持续的方式和以受控的速率向患者递送低剂量水平的药物。 该系统包括可湿性聚合物基质，其中分散有多个颗粒，其含有基本均匀的渗透活性赋形剂混合物和不超过约10重量％的药物。 该系统特别适用于递送治疗性大分子如蛋白质药物。 例举表皮生长因子的递送。
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公开(公告)号：US06984393B2
公开(公告)日：2006-01-10
申请号：US10139643
申请日：2002-05-07
申请人： Brian G. Amsden
发明人： Brian G. Amsden
CPC分类号： A61K47/593
摘要： This invention relates to thermally crosslinked and photo-crosslinked biodegradable and biocompatible elastomeric polymers. The elastomers can be used for biomedical devices such as needles, stents, catheters, scaffolds for tissue engineering, and implantable drug delivery devices. The photo-crosslinked elastomers are particularly useful for delivery devices for proteins and peptides.
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公开(公告)号：US06224794B1
公开(公告)日：2001-05-01
申请号：US09305857
申请日：1999-05-05
IPC分类号： B05D700
CPC分类号： B01J13/02 , B01J2/06 , B01J13/04 , C08J3/14 , Y10T428/2984 , Y10T428/2985
摘要： A process for forming microspheres that includes passing a first composition containing polymer and solvent through an orifice and directly into a second composition containing water and a microsphere-stabilizing agent, under at least one of conditions (a) and (b), wherein (a) the first composition flows through a first conduit along a first path and exits the first conduit at the orifice, the second composition flows through a second conduit along a second path in an upstream to downstream direction, the first conduit is connected to the second conduit and terminates at the orifice, the first and second paths being orientated at an angle &thgr; relative to each other, wherein 0°
摘要翻译： 一种形成微球的方法，其包括在至少一种条件（a）和（b）中使包含聚合物和溶剂的第一组合物通过孔直接进入包含水和微球稳定剂的第二组合物中，其中（a ）第一组合物沿着第一路径流过第一管道并在孔处离开第一管道，第二组合物沿着第二路径沿上游方向流动通过第二管道，第一管道连接到第二管道 并且在孔口处终止，第一和第二路径相对于彼此以角度θ定向，其中0°<180°; （b）第一组合物处于第一温度并且包括具有沸点的溶剂，第二组合物处于第二温度，溶剂的沸点小于第二温度; 以及形成包含水和微球的组合物，所述微球至少部分地由所述聚合物形成。 这种微球适用于递送用于动物，水族和人类使用的生物活性剂，作为放射成像组织的手段，以及用于控制释放农药。
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公开(公告)号：US5302397A
公开(公告)日：1994-04-12
申请号：US793836
申请日：1991-11-19
申请人： Brian G. Amsden , Yu-Ling Cheng
发明人： Brian G. Amsden , Yu-Ling Cheng
CPC分类号： A61K38/47 , A61K38/1808 , A61K9/0004 , A61K9/2009 , A61K9/2027
摘要： Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.
摘要翻译： 本文描述了一种药物递送系统，其用于以持续的方式和以受控的速率向患者递送低剂量水平的药物。 该系统包括可湿性聚合物基质，其中分散有多个颗粒，其含有基本均匀的渗透活性赋形剂混合物和不超过约10重量％的药物。 该系统特别适用于递送治疗性大分子如蛋白质药物。 例举表皮生长因子的递送。
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