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公开(公告)号:US08529933B2
公开(公告)日:2013-09-10
申请号:US12843357
申请日:2010-07-26
CPC分类号: A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要: This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译: 本发明涉及结合生物聚合物载体的生物矿物基水泥,用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物。 本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。
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公开(公告)号:US20110021427A1
公开(公告)日:2011-01-27
申请号:US12843357
申请日:2010-07-26
CPC分类号: A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要: This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译: 本发明涉及结合生物聚合物载体的生物矿物基水泥,用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物。 本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。
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公开(公告)号:US09399086B2
公开(公告)日:2016-07-26
申请号:US12508856
申请日:2009-07-24
CPC分类号: A61L31/121 , A61F2/30724 , A61F2/4455 , A61F2002/30029 , A61F2002/30034 , A61F2002/30062 , A61F2002/30187 , A61F2002/30957 , A61F2002/30973 , A61F2002/4475 , A61L27/425 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2400/08 , A61L2400/18 , A61L2420/02 , A61L2420/04 , B05D1/18 , B05D3/0272 , B29C45/0055 , B29C45/14795 , B29C2045/0058 , B29K2071/00 , B29L2031/7532 , C04B38/0051 , C04B41/4586 , C04B41/81 , C04B2235/606 , C08L71/12
摘要: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.
摘要翻译: 提供可植入的医疗设备。 在一个实施例中,装置包括具有限定装置的外部轮廓的外表面的主体。 主体包括多孔基体,其包括由多个相互连接的支柱限定的一系列相互连接的大孔,每个支柱包括中空的内部。 填充材料基本上填充了一系列互连的大孔的至少一部分。 主体的外表面包括与多个相互连接的支柱的至少一部分的中空内部连通的多个开口。 在该实施例的另一方面,除了暴露的开口之外,外表面还包括填充材料和多孔基体的暴露区域。 在另一方面,多孔基质由生物可吸收的陶瓷形成,填料是生物稳定的聚合材料。 仍然,还公开了与该实施例和其他实施例相关的其它方面。
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公开(公告)号:US20110022180A1
公开(公告)日:2011-01-27
申请号:US12508856
申请日:2009-07-24
CPC分类号: A61L31/121 , A61F2/30724 , A61F2/4455 , A61F2002/30029 , A61F2002/30034 , A61F2002/30062 , A61F2002/30187 , A61F2002/30957 , A61F2002/30973 , A61F2002/4475 , A61L27/425 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2400/08 , A61L2400/18 , A61L2420/02 , A61L2420/04 , B05D1/18 , B05D3/0272 , B29C45/0055 , B29C45/14795 , B29C2045/0058 , B29K2071/00 , B29L2031/7532 , C04B38/0051 , C04B41/4586 , C04B41/81 , C04B2235/606 , C08L71/12
摘要: Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.
摘要翻译: 提供可植入的医疗设备。 在一个实施例中,装置包括具有限定装置的外部轮廓的外表面的主体。 主体包括多孔基体,其包括由多个相互连接的支柱限定的一系列相互连接的大孔,每个支柱包括中空的内部。 填充材料基本上填充了一系列互连的大孔的至少一部分。 主体的外表面包括与多个相互连接的支柱的至少一部分的中空内部连通的多个开口。 在该实施例的另一方面,除了暴露的开口之外,外表面还包括填充材料和多孔基体的暴露区域。 在另一方面,多孔基质由生物可吸收的陶瓷形成,填料是生物稳定的聚合材料。 仍然,还公开了与该实施例和其他实施例相关的其它方面。
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