公开(公告)号：US07582455B2

公开(公告)日：2009-09-01

申请号：US11411229

申请日：2006-04-26

申请人： Brian J. Brazeau ,  Ellen Burke ,  Mervyn DeSouza ,  Steven J. Gort ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Peter Luginbuhl ,  Sara C. McFarlan ,  Toby Richardson ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

发明人： Brian J. Brazeau ,  Ellen Burke ,  Mervyn DeSouza ,  Steven J. Gort ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Peter Luginbuhl ,  Sara C. McFarlan ,  Toby Richardson ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

IPC分类号： C12P17/10

CPC分类号： C12P17/10 ,  C12N9/1096 ,  C12N9/90

摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

摘要翻译： 使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。 这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

公开(公告)号：US20060252135A1

公开(公告)日：2006-11-09

申请号：US11411229

申请日：2006-04-26

申请人： Brian Brazeau ,  Ellen Burke ,  Mervyn DeSouza ,  Steven Gort ,  Paula Hicks ,  Sherry Kollmann ,  Peter Luginbuhl ,  Sara McFarlan ,  Toby Richardson ,  Fernando Sanchez-Riera ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

发明人： Brian Brazeau ,  Ellen Burke ,  Mervyn DeSouza ,  Steven Gort ,  Paula Hicks ,  Sherry Kollmann ,  Peter Luginbuhl ,  Sara McFarlan ,  Toby Richardson ,  Fernando Sanchez-Riera ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

IPC分类号： C12N9/10 ,  C12P13/22 ,  C12N1/21

CPC分类号： C12P17/10 ,  C12N9/1096 ,  C12N9/90

摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

公开(公告)号：US20070099277A1

公开(公告)日：2007-05-03

申请号：US11545024

申请日：2006-10-10

申请人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann

发明人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann

IPC分类号： C12P13/22 ,  C12N1/21

CPC分类号： C12P17/10

摘要： Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

摘要翻译： 提供了莫纳甜甜味剂体内生产的产品和方法。 产品包括经遗传修饰以分泌或改善莫纳甜分泌的微生物; 经遗传修饰以产生莫纳甜的微生物; 和经遗传修饰以分泌或改善莫纳甜分泌并产生莫纳甜的微生物。 所述方法包括在这种遗传工程微生物中产生莫纳甜。

公开(公告)号：US20070105938A1

公开(公告)日：2007-05-10

申请号：US11379528

申请日：2006-04-20

申请人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

发明人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

IPC分类号： C12P13/22 ,  A61K31/405

CPC分类号： C12P17/10 ,  A61K31/7048 ,  Y02A50/473

摘要： Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

摘要翻译： 提供了莫纳甜甜味剂体内生产的产品和方法。 产品包括经遗传修饰以分泌或改善莫纳甜分泌的微生物; 经遗传修饰以产生莫纳甜的微生物; 和经遗传修饰以分泌或改善莫纳甜分泌并产生莫纳甜的微生物。 这些方法包括在这种基因工程微生物中产生莫纳甜。