公开(公告)号：US20060228789A1

公开(公告)日：2006-10-12

申请号：US11398807

申请日：2006-04-06

Applicant: Thomas Jeffries ,  Haiying Ni ,  Jose Laplaza

Inventor： Thomas Jeffries ,  Haiying Ni ,  Jose Laplaza

IPC: C12P7/06 ,  C12N1/18

CPC classification number: C12P7/06 ,  C12R1/865 ,  Y02E50/17

Abstract: Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as methods of fermenting xylose to obtain ethanol using the recombinant yeast strains.

Abstract translation: 公开了表达木糖还原酶，木糖醇脱氢酶和木酮糖激酶并且具有降低的PHO13或PHO13直向同源物的表达的木糖发酵的重组酵母菌株，以及使用重组酵母菌株发酵木糖以获得乙醇的方法。

公开(公告)号：US20110020882A1

公开(公告)日：2011-01-27

申请号：US12811491

申请日：2008-12-31

Applicant: Mervyn L. de Souza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza ,  Joshua M. Lundorff ,  Sara C. McFarlan ,  Erin Marasco ,  Wei Niu ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David P. Weiner ,  Ellen Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

Inventor： Mervyn L. de Souza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza ,  Joshua M. Lundorff ,  Sara C. McFarlan ,  Erin Marasco ,  Wei Niu ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David P. Weiner ,  Ellen Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

IPC: C12P17/10

CPC classification number: C12P13/227 ,  C12N9/0004 ,  C12N9/1096 ,  C12P17/10

Abstract: The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.

Abstract translation: 本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。 还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

公开(公告)号：US08785162B2

公开(公告)日：2014-07-22

申请号：US12811491

申请日：2008-12-31

Applicant: Mervyn L. De Souza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza ,  Joshua M. Lundorff ,  Sara C. McFarlan ,  Erin Marasco ,  Wei Niu ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

Inventor： Mervyn L. De Souza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza ,  Joshua M. Lundorff ,  Sara C. McFarlan ,  Erin Marasco ,  Wei Niu ,  Fernando A. Sanchez-Riera ,  Christopher Solheid ,  David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

IPC: C12P17/10 ,  C12P13/22 ,  C12P13/04 ,  C12N9/10 ,  C12P21/06 ,  C12P19/34 ,  C12N1/20 ,  C07H21/04 ,  C07K1/00

CPC classification number: C12P13/227 ,  C12N9/0004 ,  C12N9/1096 ,  C12P17/10

Abstract: The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.

Abstract translation: 本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。 还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

公开(公告)号：US20070105938A1

公开(公告)日：2007-05-10

申请号：US11379528

申请日：2006-04-20

Applicant: James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

Inventor： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

IPC: C12P13/22 ,  A61K31/405

CPC classification number: C12P17/10 ,  A61K31/7048 ,  Y02A50/473

Abstract: Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

Abstract translation: 提供了莫纳甜甜味剂体内生产的产品和方法。 产品包括经遗传修饰以分泌或改善莫纳甜分泌的微生物; 经遗传修饰以产生莫纳甜的微生物; 和经遗传修饰以分泌或改善莫纳甜分泌并产生莫纳甜的微生物。 这些方法包括在这种基因工程微生物中产生莫纳甜。

公开(公告)号：US08153405B2

公开(公告)日：2012-04-10

申请号：US11379528

申请日：2006-04-20

Applicant: James C. Anderson ,  Mervyn L. DeSouza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza

Inventor： James C. Anderson ,  Mervyn L. DeSouza ,  Paula M. Hicks ,  Sherry R. Kollmann ,  Jose Laplaza

IPC: C12P13/22 ,  C12N1/21

CPC classification number: C12P17/10 ,  A61K31/7048 ,  Y02A50/473

Abstract: Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

公开(公告)号：US20080020434A1

公开(公告)日：2008-01-24

申请号：US11714279

申请日：2007-03-06

Applicant: Brian Brazeau ,  Mervyn De Souza ,  Steven Gort ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza ,  Sara McFarlan ,  Fernando Sanchez-Riera ,  Christopher Solheid

Inventor： Brian Brazeau ,  Mervyn De Souza ,  Steven Gort ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza ,  Sara McFarlan ,  Fernando Sanchez-Riera ,  Christopher Solheid

IPC: C12P13/02 ,  C07H21/04 ,  C12N1/20 ,  C12N9/00 ,  C12P13/22 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90

CPC classification number: C12N9/1096 ,  C12N9/90 ,  C12P17/10

Abstract: Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

Abstract translation: 使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。 这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

公开(公告)号：US20110045547A1

公开(公告)日：2011-02-24

申请号：US12828714

申请日：2010-07-01

Applicant: Mervyn L. de Souza ,  Wei Niu ,  Jose Laplaza ,  Christopher Solheid ,  Sherry R. Kollmann ,  Joshua M. Lundorff ,  Paula M. Hicks ,  Sara C. McFarlan ,  Fernando A. Sanchez-Riera ,  David P. Weiner ,  Ellen Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

Inventor： Mervyn L. de Souza ,  Wei Niu ,  Jose Laplaza ,  Christopher Solheid ,  Sherry R. Kollmann ,  Joshua M. Lundorff ,  Paula M. Hicks ,  Sara C. McFarlan ,  Fernando A. Sanchez-Riera ,  David P. Weiner ,  Ellen Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca

IPC: C12P13/22 ,  C12P17/10

CPC classification number: C12N9/90 ,  C12P13/06 ,  C12P13/22 ,  C12P17/10

Abstract: The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.

Abstract translation: 本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。 还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

公开(公告)号：US20060088911A1

公开(公告)日：2006-04-27

申请号：US10973274

申请日：2004-10-27

Applicant: Jose Laplaza ,  Thomas Jeffries

Inventor： Jose Laplaza ,  Thomas Jeffries

IPC: C12P21/06 ,  C07H21/04 ,  C12N15/74 ,  C12N1/18

CPC classification number: C12N9/00 ,  C12N15/815

Abstract: Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein.