公开(公告)号：US20120136418A1

公开(公告)日：2012-05-31

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20120136417A1

公开(公告)日：2012-05-31

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120136344A1

公开(公告)日：2012-05-31

申请号：US13279321

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US08945107B2

公开(公告)日：2015-02-03

申请号：US13279327

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Francesco Piccagli ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US20120150267A1

公开(公告)日：2012-06-14

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61F7/12

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09439708B2

公开(公告)日：2016-09-13

申请号：US13279326

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09060754B2

公开(公告)日：2015-06-23

申请号：US13279328

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Seamus Ledwith ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00255 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery. The cryotherapeutic device can further include a supply lumen configured to carry liquid refrigerant toward the cooling assembly. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据特定实施例构造的冷冻治疗装置包括细长轴和在轴的远端部分处的冷却组件。 轴可以被配置为将血管内远端部分定位在肾动脉内或其他邻近肾动脉处的处置部位。 冷冻治疗装置还可以包括被配置为将液体制冷剂运送到冷却组件的供应管腔。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20120130360A1

公开(公告)日：2012-05-24

申请号：US13279326

申请日：2011-10-23

申请人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

发明人： Naomi Buckley ,  Benjamin J. Clark ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Eric Ryba ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Roman Turovskiy ,  Lana Woolley ,  Denise Zarins ,  Mark Gelfand ,  Mark S. Leung ,  Barry Mullins ,  Michael Turovskiy

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

公开(公告)号：US09060755B2

公开(公告)日：2015-06-23

申请号：US13279330

申请日：2011-10-23

申请人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

发明人： Naomi Buckley ,  Michael Cummins ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gary Kelly ,  Grace Kelly ,  John Kelly ,  Micheal Moriarty ,  Karun D. Naga ,  Fiachra Sweeney ,  Vincenzo Tilotta ,  Ronan Wood ,  Lana Woolley ,  Denise Zarins ,  Mark S. Leung ,  Mark Gelfand ,  Barry Mullins

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

摘要翻译： 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

公开(公告)号：US20150126986A1

公开(公告)日：2015-05-07

申请号：US14114345

申请日：2012-04-25

申请人： Brian Kelly ,  John Kelly ,  Gary Kelly ,  Barry Mullins

发明人： Brian Kelly ,  John Kelly ,  Gary Kelly ,  Barry Mullins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/00244 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Embodiments related to cryogenically ablating a portion of the inner surface of a vessel by constraining a cryoballoon using various apparatuses and methods are disclosed. For example, a catheter can include a cryoballoon for ablation of the vessel wall and a constraining element disposed substantially in parallel with the cryoballoon to deflect or offset a portion of the cryoballoon away from non-target tissue of the vessel wall and prevent ablation of the non-target tissue. Partial circumferential, non-continuous, or helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The constraining element may be, for example, a second inflatable balloon or one or more self-expanding prongs.

摘要翻译： 公开了通过使用各种装置和方法约束低温球来低温地烧蚀容器的内表面的一部分的实施例。 例如，导管可以包括用于消融血管壁的低温球和约束元件，该约束元件基本上与低血球平行地设置，以使冷冻球的一部分远离血管壁的非目标组织偏转或偏移，并防止 非目标组织。 部分圆周，非连续或螺旋消融可有效治疗各种肾，心肾和其他疾病，包括但不限于高血压，心力衰竭，肾脏疾病，肾衰竭，对比肾病，心律失常和心肌 梗死。 约束元件可以是例如第二可膨胀气囊或一个或多个自膨胀尖头。