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公开(公告)号：US4867969A
公开(公告)日：1989-09-19
申请号：US153309
申请日：1988-02-08
CPC分类号： A61M31/002 , A61K9/0004
摘要： A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.
摘要翻译： 包含药物，中性水凝胶和离子水凝胶的物质组合物。 组合物可以随时间从递送系统施用于生物受体。
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公开(公告)号：US5178867A
公开(公告)日：1993-01-12
申请号：US747899
申请日：1991-08-19
申请人： George V. Guittard , Howard A. Carpenter , Ernest S. Quan , Patrick S. Wong , Lawrence G. Hamel
发明人： George V. Guittard , Howard A. Carpenter , Ernest S. Quan , Patrick S. Wong , Lawrence G. Hamel
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： The invention pertains to a dosage form for orally administering a drug in eight hours or less to the stomach and small intestine for a therapeutic result.
摘要翻译： 本发明涉及在8小时以内口服给药的剂型，用于治疗结果。
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3.发明授权Method of delivering drug with aid of effervescent activity generated in environment of use 失效通过使用环境中产生的泡腾活性来输送药物的方法
公开(公告)号：US4265874A
公开(公告)日：1981-05-05
申请号：US143644
申请日：1980-04-25
申请人： Pieter Bonsen , Patrick S. Wong , Felix Theeuwes
发明人： Pieter Bonsen , Patrick S. Wong , Felix Theeuwes
CPC分类号： A61K9/0004
摘要： A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.
摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室的半透壁，壳体（1）在中性和酸性条件下表现出有限溶解度的药物; 和（2）能够在酸性存在下在使用环境中放出二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。
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4.发明授权Method of delivering drug with aid of effervescent activity generated in environment of use 失效通过使用环境中产生的泡腾活性来输送药物的方法
公开(公告)号：US4344929A
公开(公告)日：1982-08-17
申请号：US228091
申请日：1981-01-26
申请人： Pieter Bonsen , Patrick S. Wong , Felix Theeuwes
发明人： Pieter Bonsen , Patrick S. Wong , Felix Theeuwes
CPC分类号： A61K9/0004
摘要： A method is disclosed for delivering a drug substantially-free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment housing (1) a drug that exhibits limited solubility under neutral and acid conditions, and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.
摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室壳体（1）的半透壁，其在中性和酸性条件下表现出有限的溶解性，和（2）能够在使用环境中存在酸的情况下能够释放二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。
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公开(公告)号：US5232705A
公开(公告)日：1993-08-03
申请号：US864824
申请日：1992-04-01
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译： 公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。 在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。
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公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译： 公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。 在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。
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公开(公告)号：US4842867A
公开(公告)日：1989-06-27
申请号：US861188
申请日：1986-05-09
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
IPC分类号： A61K31/445 , A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译： 一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。
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8.发明授权
公开(公告)号：US5028434A
公开(公告)日：1991-07-02
申请号：US390021
申请日：1989-08-07
CPC分类号： A61K31/44 , A61K9/0004
摘要： A dosage form is disclosed comprising nilvadipine for administering to a patient in need of cardiovascular therapy.
摘要翻译： 公开了一种剂型，其包含用于对需要心血管治疗的患者施用的尼伐地平。
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公开(公告)号：US4460367A
公开(公告)日：1984-07-17
申请号：US397462
申请日：1982-07-12
CPC分类号： A61F5/441 , A61M1/0096
摘要： A patient-care system is disclosed comprising a container housing a device that delivers an agent for controlling the presence of pathogens. Also, the device and a method are disclosed using the device for preventing pathogenic infections.
摘要翻译： 公开了一种患者保健系统，其包括容纳用于控制病原体存在的药剂的装置的容器。 此外，使用用于预防病原体感染的装置公开了该装置和方法。
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10.发明授权Method for delivering an agent with biocidal activity in a body fluid receiving container 失效用于在体液接收容器中递送具有杀生物活性的药剂的方法
公开(公告)号：US4445889A
公开(公告)日：1984-05-01
申请号：US397507
申请日：1982-07-12
CPC分类号： A61F5/44 , A61M1/0096
摘要： A method for preventing an infection in a patient introduced through a indwelling catheter, the method comprising, connecting the patient to the catheter, connecting the catheter to a fluid receiving container, admitting into the container a biocidal dispensing device, and releasing a biocide into fluid in the container for inhibiting the growth of infectious bacteria in the container and concomitantly their introduction into the catheter and the patient.
摘要翻译： 一种用于防止通过留置导管引入的患者的感染的方法，所述方法包括：将患者连接到导管，将导管连接到流体接收容器，将容器中的杀生物剂分配装置，以及将杀生物剂释放到流体中 在用于抑制容器中的感染性细菌生长的容器中并且伴随地引入到导管和患者体内。
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