公开(公告)号：US07709007B2

公开(公告)日：2010-05-04

申请号：US10934003

申请日：2004-09-02

申请人： Brian R. Murphy ,  Peter L. Collins ,  Stephen S. Whitehead ,  Alexander A. Bukreyev ,  Katalin Juhasz ,  Michael N. Teng

发明人： Brian R. Murphy ,  Peter L. Collins ,  Stephen S. Whitehead ,  Alexander A. Bukreyev ,  Katalin Juhasz ,  Michael N. Teng

IPC分类号： A61K39/155

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18561

摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.

摘要翻译： 减毒的呼吸道合胞病毒（RSV）及其疫苗组合物通过将与将减毒表型相关的特异性突变引入野生型或RSV，通过冷通道或引入产生具有温度敏感性（ts）或 冷适应（ca）表型。 或者，重组RSV及其疫苗组合物结合了在感染性RSV中指定所需结构和/或表型特征的减毒和其它突变。 重组RSV包含通过在感染性RSV克隆中选择的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。 通过施用减毒的，生物衍生的或重组的RSV，刺激个体的免疫系统以诱导针对天然RSV感染的保护，或多重抗RSV和另一种病原体如PIV的感染。

公开(公告)号：US5993824A

公开(公告)日：1999-11-30

申请号：US892403

申请日：1997-07-15

申请人： Brian R. Murphy ,  Peter L. Collins ,  Stephen S. Whitehead ,  Alexander A. Bukreyev ,  Katalin Juhasz ,  Michael N. Teng

发明人： Brian R. Murphy ,  Peter L. Collins ,  Stephen S. Whitehead ,  Alexander A. Bukreyev ,  Katalin Juhasz ,  Michael N. Teng

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/155 ,  A61P31/12 ,  C07K14/135 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/04 ,  C12N15/00

CPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/00 ,  C12N2760/18522 ,  C12N2760/18561

摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.

公开(公告)号：US10696194B1

公开(公告)日：2020-06-30

申请号：US16208718

申请日：2018-12-04

申请人： Katalin Juhasz

发明人： Katalin Juhasz

IPC分类号： A47C15/00 ,  B60N2/30 ,  B60R22/10 ,  B60N2/26

摘要： A vehicle seat with fold down child seat includes a passenger seat and a convertible child seat section. In a first seat configuration, the convertible child seat section may be for use by an adult or adolescent. In a second seat configuration, the convertible child seat section may be for use by a child. The convertible child seat section may includes a child seat back that rotates to present a front side for adult seating or a rear side for child seating and a child seat cushion that rotates to present a top side for adult seating or a bottom side for child seating. The seat back and seat cushion may rotate on a seat back spindle and seat bottom cushion, respectively. The convertible child seat section may include a harness. A vehicle seat may comprise multiple convertible child seat sections.

公开(公告)号：US20060159703A1

公开(公告)日：2006-07-20

申请号：US10934003

申请日：2004-09-02

申请人： Brian Murphy ,  Peter Collins ,  Stephen Whitehead ,  Alexander Bukreyev ,  Katalin Juhasz ,  Michael Teng

发明人： Brian Murphy ,  Peter Collins ,  Stephen Whitehead ,  Alexander Bukreyev ,  Katalin Juhasz ,  Michael Teng

IPC分类号： A61K39/155 ,  C12N7/00 ,  C07K14/115

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18561

摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.

摘要翻译： 减毒的呼吸道合胞病毒（RSV）及其疫苗组合物通过将与将减毒表型相关的特异性突变引入野生型或RSV，通过冷通道或引入产生具有温度敏感性（ts）或 冷适应（ca）表型。 或者，重组RSV及其疫苗组合物结合了在感染性RSV中指定所需结构和/或表型特征的减毒和其它突变。 重组RSV包含通过在感染性RSV克隆中选择的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。 通过施用减毒的，生物衍生的或重组的RSV，刺激个体的免疫系统以诱导针对天然RSV感染的保护，或多重抗RSV和另一种病原体如PIV的感染。