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    Reagents and methods for use in cancer diagnosis, classification and therapy
    2.
    发明申请
    Reagents and methods for use in cancer diagnosis, classification and therapy 审中-公开
    用于癌症诊断，分类和治疗的试剂和方法

    公开(公告)号：US20050112622A1

    公开(公告)日：2005-05-26

    申请号：US10915059

    申请日：2004-08-10

    申请人： Brian Ring ,  Douglas Ross ,  Robert Seitz

    发明人： Brian Ring ,  Douglas Ross ,  Robert Seitz

    IPC分类号： G01N33/574 ,  C12Q1/68

    CPC分类号： G01N33/6893 ,  G01N33/57484 ,  G01N2500/04 ,  G01N2800/52

    摘要： Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer.

    摘要翻译： 用于分类肿瘤和鉴定新肿瘤类别和亚类的方法和试剂。 将肿瘤类别或亚类与治疗方案或结果相关联的方法，用于识别特定类别或亚类的适当（新的或已知的）治疗，以及基于类或亚类的预测结果。 新的治疗剂和治疗癌症的方法。

    Biomarker:compound correlations in cancer diagnosis and therapy
    4.
    发明申请
    Biomarker:compound correlations in cancer diagnosis and therapy 审中-公开
    生物标志物：癌症诊断与治疗中的复合相关性

    公开(公告)号：US20050227266A1

    公开(公告)日：2005-10-13

    申请号：US11050567

    申请日：2005-02-03

    申请人： Douglas Ross ,  Brian Ring ,  Robert Seitz

    发明人： Douglas Ross ,  Brian Ring ,  Robert Seitz

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N2500/00

    摘要： The present invention provides methods and reagents relating to establishing and using biomarker:chemical compound correlations. The invention provides correlated biomarker:compound pairs, and further provides methods of using such pairs, for example, in the identification of tumors or tumor cells likely to be responsive or resistant to particular therapy, and/or the identification of chemical compounds likely (or unlikely) to be useful in the treatment of particular tumors.

    摘要翻译： 本发明提供了与建立和使用生物标志物有关的方法和试剂：化合物相关性。 本发明提供相关生物标志物：化合物对，并进一步提供使用这些对的方法，例如鉴定可能对特定治疗有反应或抗性的肿瘤或肿瘤细胞，和/或可能（或 不太可能）用于治疗特定肿瘤。

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    5.
    发明申请
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 审中-公开
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US20060040302A1

    公开(公告)日：2006-02-23

    申请号：US11200822

    申请日：2005-08-10

    申请人： David Botstein ,  Patrick Brown ,  Charles Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan van de Rijn

    发明人： David Botstein ,  Patrick Brown ,  Charles Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan van de Rijn

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of cancer, particularly breast cancer. cDNA microarray technology was used to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of cancer and for identification of therapies for cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗癌症，特别是乳腺癌的各种试剂。 cDNA微阵列技术用于鉴定跨越大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于诊断癌症和用于鉴定癌症疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    6.
    发明授权
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 失效
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US07118853B2

    公开(公告)日：2006-10-10

    申请号：US09916849

    申请日：2001-07-26

    申请人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    发明人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    IPC分类号： G01N33/50 ,  G01N33/53 ,  G01N33/536 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗乳腺癌的各种试剂。 本发明利用cDNA微阵列技术鉴定了大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于乳腺癌诊断和鉴定乳腺癌疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    High crown anti-rotation bolt
    7.
    发明授权
    High crown anti-rotation bolt 有权
    高冠防旋螺栓

    公开(公告)号：US07993086B2

    公开(公告)日：2011-08-09

    申请号：US12157787

    申请日：2008-06-14

    申请人： Brian Kruse ,  Brian Ring ,  Jeff Enneking

    发明人： Brian Kruse ,  Brian Ring ,  Jeff Enneking

    IPC分类号： F16B39/32

    CPC分类号： F16B39/105 ,  Y10S411/979

    摘要： The present disclosure shows an anti-rotation bolt for fastening reactor plates to prevent subsequent SCC problems wherein the bolt head has a circumferential series of anti-rotation tabs extending from the head of the bolt which are moved in by a restrainer cone which is placed on top of the bolt to allow its insertion into the plates and is removed for locking the tabs into detents formed in one of the plates to provide anti-rotation. The cone is again moved over the tabs during the removal of same leaving the bolt undamaged and fit for reuse.

    摘要翻译： 本公开示出了用于紧固反应器板以防止随后的SCC问题的防旋转螺栓，其中螺栓头具有从螺栓的头部延伸的周向系列的防旋转突出部，所述防旋转突出部被限制锥体移动， 螺栓的顶部以允许其插入板中并且被移除以将突片锁定到形成在其中一个板中的棘爪中以提供防旋转。 锥体在拆卸过程中再次移动到突片上，从而使螺栓未损坏并适合重新使用。

    Ihigh crown anti-rotation bolt
    8.
    发明申请
    Ihigh crown anti-rotation bolt 有权
    高冠防转螺栓

    公开(公告)号：US20090311072A1

    公开(公告)日：2009-12-17

    申请号：US12157787

    申请日：2008-06-14

    申请人： Brian Kruse ,  Brian Ring ,  Jeff Enneking

    发明人： Brian Kruse ,  Brian Ring ,  Jeff Enneking

    IPC分类号： F16B39/00

    CPC分类号： F16B39/105 ,  Y10S411/979

    摘要： The present disclosure shows an anti-rotation bolt for fastening reactor plates to prevent subsequent SCC problems wherein the bolt head has a circumferential series of anti-rotation tabs extending from the head of the bolt which are moved in by a restrainer cone which is placed on top of the bolt to allow its insertion into the plates and is removed for locking the tabs into detents formed in one of the plates to provide anti-rotation. The cone is again moved over the tabs during the removal of same leaving the bolt undamaged and fit for reuse.

    摘要翻译： 本公开示出了用于紧固反应器板以防止随后的SCC问题的防旋转螺栓，其中螺栓头具有从螺栓的头部延伸的周向系列的防旋转突出部，所述防旋转突出部被限制锥体移动， 螺栓的顶部以允许其插入板中并且被移除以将突片锁定到形成在其中一个板中的棘爪中以提供防旋转。 锥体在拆卸过程中再次移动到突片上，从而使螺栓未损坏并适合重新使用。