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15 条记录 (耗时 0.037 秒)

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    1.
    发明申请
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 审中-公开
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US20060040302A1

    公开(公告)日：2006-02-23

    申请号：US11200822

    申请日：2005-08-10

    申请人： David Botstein ,  Patrick Brown ,  Charles Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan van de Rijn

    发明人： David Botstein ,  Patrick Brown ,  Charles Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan van de Rijn

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of cancer, particularly breast cancer. cDNA microarray technology was used to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of cancer and for identification of therapies for cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗癌症，特别是乳腺癌的各种试剂。 cDNA微阵列技术用于鉴定跨越大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于诊断癌症和用于鉴定癌症疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    2.
    发明授权
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 失效
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US07118853B2

    公开(公告)日：2006-10-10

    申请号：US09916849

    申请日：2001-07-26

    申请人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    发明人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    IPC分类号： G01N33/50 ,  G01N33/53 ,  G01N33/536 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗乳腺癌的各种试剂。 本发明利用cDNA微阵列技术鉴定了大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于乳腺癌诊断和鉴定乳腺癌疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    Reagents and methods for use in cancer diagnosis, classification and therapy
    3.
    发明申请
    Reagents and methods for use in cancer diagnosis, classification and therapy 审中-公开
    用于癌症诊断，分类和治疗的试剂和方法

    公开(公告)号：US20050112622A1

    公开(公告)日：2005-05-26

    申请号：US10915059

    申请日：2004-08-10

    申请人： Brian Ring ,  Douglas Ross ,  Robert Seitz

    发明人： Brian Ring ,  Douglas Ross ,  Robert Seitz

    IPC分类号： G01N33/574 ,  C12Q1/68

    CPC分类号： G01N33/6893 ,  G01N33/57484 ,  G01N2500/04 ,  G01N2800/52

    摘要： Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of cancer.

    摘要翻译： 用于分类肿瘤和鉴定新肿瘤类别和亚类的方法和试剂。 将肿瘤类别或亚类与治疗方案或结果相关联的方法，用于识别特定类别或亚类的适当（新的或已知的）治疗，以及基于类或亚类的预测结果。 新的治疗剂和治疗癌症的方法。

    Biomarker:compound correlations in cancer diagnosis and therapy
    6.
    发明申请
    Biomarker:compound correlations in cancer diagnosis and therapy 审中-公开
    生物标志物：癌症诊断与治疗中的复合相关性

    公开(公告)号：US20050227266A1

    公开(公告)日：2005-10-13

    申请号：US11050567

    申请日：2005-02-03

    申请人： Douglas Ross ,  Brian Ring ,  Robert Seitz

    发明人： Douglas Ross ,  Brian Ring ,  Robert Seitz

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N2500/00

    摘要： The present invention provides methods and reagents relating to establishing and using biomarker:chemical compound correlations. The invention provides correlated biomarker:compound pairs, and further provides methods of using such pairs, for example, in the identification of tumors or tumor cells likely to be responsive or resistant to particular therapy, and/or the identification of chemical compounds likely (or unlikely) to be useful in the treatment of particular tumors.

    摘要翻译： 本发明提供了与建立和使用生物标志物有关的方法和试剂：化合物相关性。 本发明提供相关生物标志物：化合物对，并进一步提供使用这些对的方法，例如鉴定可能对特定治疗有反应或抗性的肿瘤或肿瘤细胞，和/或可能（或 不太可能）用于治疗特定肿瘤。

    Elevating transporter with mechanical drive
    9.
    发明授权
    Elevating transporter with mechanical drive 失效
    提升运输机械与机械驱动

    公开(公告)号：US4417634A

    公开(公告)日：1983-11-29

    申请号：US232561

    申请日：1981-02-09

    申请人： Manfred W. Quaeck ,  Douglas Ross

    发明人： Manfred W. Quaeck ,  Douglas Ross

    IPC分类号： B60G17/033 ,  B60P1/02 ,  B62D61/10 ,  B62D63/00

    CPC分类号： B62D61/10 ,  B60G17/033 ,  B60P1/02

    摘要： An elevating transport vehicle has its frame carried by steerable idler bogies and by drive wheels on an axle assembly having a mechanical drive via a telescopic drive shaft from an engine and transmission mounted on the frame. The drive axle assembly is supported beneath the frame by a pivotally mounted tie rod and swing arm at each side of the vehicle. Hydraulic cylinders act between the frame and the bogies and swing arms to raise and lower the vehicle frame and with a telescopic drive shaft from the first to the second drive axle assembly.

    摘要翻译： 升降运输车辆的框架由可转向的惰轮转向架承载，并且驱动轮由具有机械驱动力的轴组件驱动，该驱动轮通过来自发动机的伸缩驱动轴和安装在框架上的变速器。 驱动桥组件通过在车辆的每一侧的枢转安装的拉杆和摆臂支撑在框架下方。 液压缸在框架和转向架和摆臂之间起作用，以使车架升高和降低，以及从第一驱动轴组件到第二驱动轴组件的伸缩驱动轴。

    Trailer for handling container-carrying pallet frames
    10.
    发明授权
    Trailer for handling container-carrying pallet frames 失效
    拖车用于处理集装箱托盘架

    公开(公告)号：US4101144A

    公开(公告)日：1978-07-18

    申请号：US827616

    申请日：1977-10-11

    申请人： Douglas Ross ,  Keith Blackburn

    发明人： Douglas Ross ,  Keith Blackburn

    IPC分类号： B60P1/64 ,  B62D21/02

    CPC分类号： B60P1/6427

    摘要： A trailer having a rear central guide post and primary rear load carrying wheels which can be elevated to transfer ground contact to caster wheels and lower the trailer bed so that the trailer can be readily maneuvered while the trailer is backed on the caster wheels to assist in properly aligning the trailer beneath a leg-mounted pallet frame for containers having a center guide slot for receiving the guide post, whereupon the primary wheels are lowered to lift the pallet frame free of the ground for transport on the trailer.