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公开(公告)号:US20120172345A1
公开(公告)日:2012-07-05
申请号:US13207753
申请日:2011-08-11
申请人: Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人: Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号: A61K31/4439 , A61K31/427 , A61K31/381 , C07D413/14 , C07D413/04 , C07D417/04 , C07D409/14 , C07D409/04 , C07D417/14 , A61P29/00 , A61P9/00 , A61P37/08 , A61P19/02 , A61P9/12 , A61P35/00 , A61K31/5377
CPC分类号: C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要: This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA-i-a或IB-i-a及其子集的化合物:其中Z,HY,R1,R2,R3,G1,W,n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08796268B2
公开(公告)日:2014-08-05
申请号:US13207753
申请日:2011-08-11
申请人: Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人: Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号: A61K31/5377 , C07D413/04 , C07D413/14
CPC分类号: C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要: This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA-i-a或IB-i-a及其子集的化合物:其中Z,HY,R1,R2,R3,G1,W,n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120214794A1
公开(公告)日:2012-08-23
申请号:US13272413
申请日:2011-10-13
申请人: Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
发明人: Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
IPC分类号: A61K31/55 , A61K31/4436 , C07D495/04 , A61K31/4439 , C07D295/10 , A61K31/5377 , C07D513/04 , A61K31/542 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/08 , A61P19/02 , A61P37/06 , A61P9/12 , A61P9/04 , C07D213/32
CPC分类号: C07D519/00 , A61K9/2018 , C07D333/78 , C07D409/04 , C07D409/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要: This invention provides compounds of formula I-A or I-B: wherein HY, G1, G2, R2, R12, W1, W2, n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I-A或I-B的化合物:其中HY,G1,G2,R2,R12,W1,W2,n和环A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08765746B2
公开(公告)日:2014-07-01
申请号:US13272413
申请日:2011-10-13
申请人: Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
发明人: Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
IPC分类号: C07D409/04 , C07D409/14 , C07D417/04 , A61K31/427 , A61K31/4196 , A61K31/5377
CPC分类号: C07D519/00 , A61K9/2018 , C07D333/78 , C07D409/04 , C07D409/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要: This invention provides compounds of formula I-A or I-B: wherein HY, G1, G2, R2, R12, W1, W2, n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式I-A或I-B的化合物:其中HY,G1,G2,R2,R12,W1,W2,n和环A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US09062038B2
公开(公告)日:2015-06-23
申请号:US13814812
申请日:2011-08-10
申请人: Masaaki Hirose , Yongbo Hu , Zhigen Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人: Masaaki Hirose , Yongbo Hu , Zhigen Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号: C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
CPC分类号: C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, G1, W, n, and A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2,G1,W,n和A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US08796271B2
公开(公告)日:2014-08-05
申请号:US13207696
申请日:2011-08-11
申请人: Masaaki Hirose , Zhigen Hu , Yongbo Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人: Masaaki Hirose , Zhigen Hu , Yongbo Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号: A61K31/4439 , A61K31/437 , A61K31/4375 , A61K31/495 , A61K31/4155 , A61K31/4725 , C07D409/14 , C07D409/04 , C07D417/14 , C07D413/14
CPC分类号: C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA-a或IB-a及其子集的化合物:其中Z,HY,R1,R2,G1,W,n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20120178723A1
公开(公告)日:2012-07-12
申请号:US13207696
申请日:2011-08-11
申请人: Masaaki Hirose , Zhigen Hu , Yongbo Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人: Masaaki Hirose , Zhigen Hu , Yongbo Hu , Hong Myung Lee , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号: A61K31/437 , C07D417/14 , A61K31/4439 , C07D409/14 , C07D495/04 , A61K31/4365 , A61K31/506 , C07D413/14 , A61K31/422 , C07D409/04 , A61K31/501 , A61K31/497 , A61K31/4725 , A61K31/4375 , A61K31/496 , C07D417/04 , A61K31/5377 , C07D413/04 , A61K31/381 , A61K31/4545 , C07D491/107 , A61K31/498 , C07D421/04 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/08 , A61P37/06 , A61P9/12 , A61K31/4436 , A61K31/655 , A61P7/02 , C07D471/04
CPC分类号: C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA-a或IB-a及其子集的化合物:其中Z,HY,R1,R2,G1,W,n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20130267563A1
公开(公告)日:2013-10-10
申请号:US13814812
申请日:2011-08-10
申请人: Masaaki Hirose , Yongbo Hu , Zhigen Hu , Hong Myung Lee , Zhan Shi , Stephan Vyskocil , Tianlin Xu
发明人: Masaaki Hirose , Yongbo Hu , Zhigen Hu , Hong Myung Lee , Zhan Shi , Stephan Vyskocil , Tianlin Xu
IPC分类号: C07D413/04 , C07D413/14
CPC分类号: C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, G1, W, n, and A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中HY,R1,R2,G1,W,n和A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US09139589B2
公开(公告)日:2015-09-22
申请号:US12657853
申请日:2010-01-28
IPC分类号: C07D345/00 , C07D517/00 , C07D487/04 , C07D417/04 , C07D419/14 , C07D471/04 , C07D513/04
CPC分类号: C07D487/04 , C07D417/04 , C07D419/14 , C07D471/04 , C07D513/04
摘要: This invention provides compounds of formula IA or IB: wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中R1,R2,G1和HY如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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公开(公告)号:US20110003806A1
公开(公告)日:2011-01-06
申请号:US12657853
申请日:2010-01-28
IPC分类号: A61K31/5377 , C07D409/00 , C07D417/14 , C07D413/14 , C07D513/04 , C07D487/04 , C07D471/04 , C07D495/04 , C07D498/04 , C07D473/00 , A61K31/4439 , A61K31/506 , A61K31/4436 , A61K31/497 , A61K31/444 , A61K31/4365 , A61K31/429 , A61K31/5025 , A61K31/427 , A61K31/4725 , A61K31/4375 , A61K31/519 , A61K31/437 , A61K31/52 , A61P29/00 , A61P9/00 , A61P9/12 , A61P9/04 , A61P37/02 , A61P37/08 , A61P35/00
CPC分类号: C07D487/04 , C07D417/04 , C07D419/14 , C07D471/04 , C07D513/04
摘要: This invention provides compounds of formula IA or IB: wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译: 本发明提供式IA或IB的化合物:其中R1,R2,G1和HY如说明书中所述。 化合物是PI3K和/或mTor的抑制剂,因此可用于治疗增殖性,炎性或心血管疾病。
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