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公开(公告)号：US20120172345A1
公开(公告)日：2012-07-05
申请号：US13207753
申请日：2011-08-11
申请人： Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人： Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/381 , C07D413/14 , C07D413/04 , C07D417/04 , C07D409/14 , C07D409/04 , C07D417/14 , A61P29/00 , A61P9/00 , A61P37/08 , A61P19/02 , A61P9/12 , A61P35/00 , A61K31/5377
CPC分类号： C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要： This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式IA-i-a或IB-i-a及其子集的化合物：其中Z，HY，R1，R2，R3，G1，W，n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
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公开(公告)号：US08796268B2
公开(公告)日：2014-08-05
申请号：US13207753
申请日：2011-08-11
申请人： Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
发明人： Brian S. Freeze , Masaaki Hirose , Yongbo Hu , Todd B. Sells , Zhan Shi , Stepan Vyskocil , Tianlin Xu
IPC分类号： A61K31/5377 , C07D413/04 , C07D413/14
CPC分类号： C07D277/56 , A61K31/4155 , A61K31/425 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/64 , C07D293/06 , C07D333/38 , C07D333/54 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/107 , C07D495/04
摘要： This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式IA-i-a或IB-i-a及其子集的化合物：其中Z，HY，R1，R2，R3，G1，W，n和A及其子集如说明书中所述。 这些化合物是PI3K的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
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公开(公告)号：US20120214794A1
公开(公告)日：2012-08-23
申请号：US13272413
申请日：2011-10-13
申请人： Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
发明人： Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
IPC分类号： A61K31/55 , A61K31/4436 , C07D495/04 , A61K31/4439 , C07D295/10 , A61K31/5377 , C07D513/04 , A61K31/542 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/08 , A61P19/02 , A61P37/06 , A61P9/12 , A61P9/04 , C07D213/32
CPC分类号： C07D519/00 , A61K9/2018 , C07D333/78 , C07D409/04 , C07D409/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： This invention provides compounds of formula I-A or I-B: wherein HY, G1, G2, R2, R12, W1, W2, n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式I-A或I-B的化合物：其中HY，G1，G2，R2，R12，W1，W2，n和环A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
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公开(公告)号：US08765746B2
公开(公告)日：2014-07-01
申请号：US13272413
申请日：2011-10-13
申请人： Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
发明人： Brian S. Freeze , Masaaki Hirose , Hong Myung Lee , Todd B. Sells , Zhan Shi , Leo R. Takaoka , Stepan Vyskocil , Tianlin Xu
IPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , A61K31/427 , A61K31/4196 , A61K31/5377
CPC分类号： C07D519/00 , A61K9/2018 , C07D333/78 , C07D409/04 , C07D409/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： This invention provides compounds of formula I-A or I-B: wherein HY, G1, G2, R2, R12, W1, W2, n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式I-A或I-B的化合物：其中HY，G1，G2，R2，R12，W1，W2，n和环A如说明书中所述。 化合物是PI3K和/或mTor的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
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公开(公告)号：US20130150388A1
公开(公告)日：2013-06-13
申请号：US13592389
申请日：2012-08-23
IPC分类号： C07D239/47
CPC分类号： C07D239/47 , C07D239/46 , C07D473/02
摘要： Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
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公开(公告)号：US08399659B2
公开(公告)日：2013-03-19
申请号：US12472583
申请日：2009-05-27
申请人： Christoper F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christoper F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
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公开(公告)号：US09988384B2
公开(公告)日：2018-06-05
申请号：US13217729
申请日：2011-08-25
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
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公开(公告)号：US20110312943A1
公开(公告)日：2011-12-22
申请号：US13217729
申请日：2011-08-25
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
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公开(公告)号：US07572784B2
公开(公告)日：2009-08-11
申请号：US11127855
申请日：2005-05-12
申请人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： A61P35/00 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20080167292A1
公开(公告)日：2008-07-10
申请号：US11985277
申请日：2007-11-14
IPC分类号： A61K31/55
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供了极光A激酶的有效抑制剂，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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