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公开(公告)号:US07932247B2
公开(公告)日:2011-04-26
申请号:US11719336
申请日:2005-11-15
申请人: Brian W. Budzik , Anthony W. J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
发明人: Brian W. Budzik , Anthony W. J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
IPC分类号: A61K31/496 , A61K31/551 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/14 , C07D487/10
CPC分类号: C07D487/08 , C07D241/04 , C07D295/135 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/14 , C07D487/10
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号:US20090149447A1
公开(公告)日:2009-06-11
申请号:US11719336
申请日:2005-11-15
申请人: Brian W. Budzik , Anthony W.J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
发明人: Brian W. Budzik , Anthony W.J. Cooper , Jian Jin , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich , Ralph A. Rivero , Yonghui Wang , Haibo Xie , Chongjie Zhu
IPC分类号: C07D413/12 , C07D403/12 , A61K31/496 , A61K31/551 , A61K31/5377 , A61P11/00 , A61P37/08
CPC分类号: C07D487/08 , C07D241/04 , C07D295/135 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/14 , C07D487/10
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号:US20090253908A1
公开(公告)日:2009-10-08
申请号:US10598743
申请日:2005-03-11
申请人: Brian W. Budzik , Anthony W. J. Cooper , David Francis Corbett , Jian Jin , Dramane I. Laine , Yonghui Wang , Michael Lee Moore , Ralph A. Rivero , Dongchuan Shi , Feng Wang , Haibo Xie , Chongjie Zhu
发明人: Brian W. Budzik , Anthony W. J. Cooper , David Francis Corbett , Jian Jin , Dramane I. Laine , Yonghui Wang , Michael Lee Moore , Ralph A. Rivero , Dongchuan Shi , Feng Wang , Haibo Xie , Chongjie Zhu
IPC分类号: C07F5/02 , C07D241/04
CPC分类号: C07D403/12 , C07D207/14 , C07D209/42 , C07D211/56 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/50 , C07D243/08 , C07D273/02 , C07D277/62 , C07D295/135 , C07D307/68 , C07D307/84 , C07D317/62 , C07D319/14 , C07D321/10 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D453/02 , C07D487/04
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号:US20080275079A1
公开(公告)日:2008-11-06
申请号:US11997466
申请日:2006-08-02
申请人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
发明人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
IPC分类号: A61K31/437 , C07D451/02 , A61P17/00
CPC分类号: C07D451/02
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号:US20090264431A1
公开(公告)日:2009-10-22
申请号:US12193128
申请日:2008-08-18
IPC分类号: C07D413/02 , C07D207/14 , A61K31/5377 , A61K31/40
CPC分类号: C07D207/14 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/12
摘要: The invention is directed to compounds according to Formula I: wherein R1, R2a, R2b, R2c, R3, and n are defined below, and to pharmaceutically-acceptable salts thereof. They are cathepsin C inhibitors and can be used in the treatment of diseases mediated by the cathepsin C enzyme, such as COPD.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,其中R1,R2a,R2b,R2c,R3和n定义如下。 它们是组织蛋白酶C抑制剂,可用于治疗组织蛋白酶C酶介导的疾病,如COPD。
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公开(公告)号:US20080234315A1
公开(公告)日:2008-09-25
申请号:US11997451
申请日:2006-08-02
申请人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
发明人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
IPC分类号: A61K31/435 , C07D451/02 , A61P17/00
CPC分类号: C07D451/02
摘要: The present invention is directed to novel Muscarinic Acetylcholine receptor antagonists of Formula (I), pharmaceutical compositions and methods of using them. Compounds of Formula (I) are, inter alia, wherein: R1 and R2 are, independently, selected from the group consisting of 3-thienyl, pyridyl, benzyl, pyrimidyl, thiazolyl, isothiazolyl and C3-7cycloalkyl.
摘要翻译: 本发明涉及式(I)的新颖的毒蕈碱乙酰胆碱受体拮抗剂,药物组合物及其使用方法。 式(I)的化合物尤其是其中:R 1和R 2独立地选自3-噻吩基,吡啶基,苄基,嘧啶基,噻唑基,异噻唑基和C 3-7 >环烷基。
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7.POLYMER DERIVATIVES AND COMPOSITES FROM THE DISSOLUTION OF LIGNOCELLULOSICS IN IONIC LIQUIDS 审中-公开
标题翻译: 聚合物衍生物和离子液体中溶质的混合物公开(公告)号:US20080188636A1
公开(公告)日:2008-08-07
申请号:US12026998
申请日:2008-02-06
申请人: Dimitris Argyropoulos , Haibo Xie
发明人: Dimitris Argyropoulos , Haibo Xie
IPC分类号: C08F251/02
CPC分类号: C08L71/02 , C08H8/00 , C08L29/04 , C08L33/20 , C08L97/005 , C08L97/02 , C08L2666/26 , C08L2666/04 , C08L2666/14
摘要: The present invention provides wood derivatives and composite materials prepared by first solvating a lignocellulosic material using an ionic liquid. The solvated lignocellulosic material can be derivatized to incorporate functional groups, particularly groups that facilitate later combination with polymer materials, including non-polymer polymers. The polymeric materials can be combined with the derivatized lignocellulosic material in solution, or the derivatized lignocellulosic material can be isolated and later combined with the polymeric material in a melt. The invention encompasses a variety of wood derivatives, composites, and nanocomposites useful for preparing multiple types of products, including membranes, fibers, and formed parts.
摘要翻译: 本发明提供了通过使用离子液体首先溶剂化木质纤维素材料制备的木材衍生物和复合材料。 溶剂化的木质纤维素材料可以被衍生化以引入官能团,特别是有助于与聚合物材料(包括非聚合物聚合物)稍后组合的基团。 聚合物材料可以与溶液中的衍生的木质纤维素材料组合,或者衍生的木质纤维素材料可以被分离并且随后在熔体中与聚合物材料组合。 本发明包括可用于制备多种类型产品的各种木材衍生物,复合材料和纳米复合材料,包括膜,纤维和成形部件。
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公开(公告)号:US20070238751A1
公开(公告)日:2007-10-11
申请号:US10599717
申请日:2005-04-07
申请人: Dramane Laine , Michael Palovich , Haibo Xie , Noemie Buffet
发明人: Dramane Laine , Michael Palovich , Haibo Xie , Noemie Buffet
IPC分类号: A61K31/439 , A61P11/00 , C07D221/22
CPC分类号: C07D451/02 , C07D451/06
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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