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    Pyrrolidine sulfonamides
    4.
    发明授权
    Pyrrolidine sulfonamides 失效
    吡咯烷磺酰胺

    公开(公告)号：US07019008B2

    公开(公告)日：2006-03-28

    申请号：US11119026

    申请日：2005-04-29

    申请人： Dashyant Dhanak ,  Steven D. Knight ,  Jian Jin ,  Ralph A. Rivero ,  Anthony Sapienza

    发明人： Dashyant Dhanak ,  Steven D. Knight ,  Jian Jin ,  Ralph A. Rivero ,  Anthony Sapienza

    IPC分类号： A61K31/496 ,  C07D409/14

    CPC分类号： C07D409/12

    摘要： A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式（I）的化合物：其中：R 1是C 1-6烷基，苄基或（CH 2 CH 2） -C（O）NH 2; 其中苄基可以是未取代的或被一个或两个C 1-6烷基，卤素，C 1-6烷氧基或亚甲二氧基取代; R 2是苯并咪唑基，喹啉基，苯并呋喃基，萘基，吲哚基，苯并噻吩基，苯基，呋喃基，噻吩基或被1,2或3个卤素取代或未取代的吡啶基， 亚烷基，C 1-3烷氧基或亚甲二氧基; X 1和X 2独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基 ，硝基，CF 3或CN; n为1,2或3; m为1,2或3; 或其药学上可接受的盐。

    Compounds Which Have Activity at M1 Receptor and Their Uses In Medicine
    5.
    发明申请
    Compounds Which Have Activity at M1 Receptor and Their Uses In Medicine 失效
    在M1受体中具有活性的化合物及其在医学中的用途

    公开(公告)号：US20080293770A1

    公开(公告)日：2008-11-27

    申请号：US12088451

    申请日：2006-09-27

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    IPC分类号： A61K31/454 ,  C07D405/14 ,  A61P25/18

    CPC分类号： C07D401/14

    摘要： Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）和盐的化合物：其中R 5选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基， 和氰基; R 6选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基，被一个或多个 氟原子和氰基; Q是氢或C 1-6烷基。 化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine
    6.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 失效
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08288412B2

    公开(公告)日：2012-10-16

    申请号：US12088451

    申请日：2006-09-27

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    IPC分类号： A61K31/454 ,  C07D405/04

    CPC分类号： C07D401/14

    摘要： Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）和盐的化合物：其中R 5选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基， 和氰基; R 6选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基，被一个或多个 氟原子和氰基; Q是氢或C 1-6烷基。 化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine.
    8.
    发明申请
    Compounds which have activity at M1 receptor and their uses in medicine. 失效
    具有M1受体活性的化合物及其在药物中的用途。

    公开(公告)号：US20080058378A1

    公开(公告)日：2008-03-06

    申请号：US11852455

    申请日：2007-09-10

    申请人： Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    发明人： Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    IPC分类号： A61K31/445 ,  A61P43/00

    CPC分类号： C07D405/12 ,  C07D235/26

    摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）化合物和盐和溶剂化物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1〜 C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6 - 被一个或多个氟原子取代的烷氧基; 和R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基， C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和C 1-6烷基， 1-6个被一个或多个氟原子取代的烷氧基，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine
    9.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 失效
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08481566B2

    公开(公告)日：2013-07-09

    申请号：US11852455

    申请日：2007-09-10

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    IPC分类号： A61K31/445 ,  C07D401/04

    CPC分类号： C07D405/12 ,  C07D235/26

    摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）化合物和盐和溶剂合物：其中R4是氟，R5选自氢，卤素，氰基，C1-6烷基，被一个或多个氟原子取代的C1-6烷基，C1-6烷氧基和C1- 6个被一个或多个氟原子取代的烷氧基; 并且R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和被一个或多个氟原子取代的C 1-6烷氧基 更多的氟原子，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。