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公开(公告)号：US11878975B2
公开(公告)日：2024-01-23
申请号：US16955097
申请日：2018-12-18
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , John L. Gilmore , Tasir Shamsul Haque , Trevor C. Sherwood , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Srinivasan Kunchithapatham Duraisamy , Subramanya Hegde , Rushith Kumar Anumula , Pitani Veera Venkata Srinivas
IPC分类号： C07D471/08 , C07D487/08 , C07D519/00 , C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
CPC分类号： C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20200308195A1
公开(公告)日：2020-10-01
申请号：US16955108
申请日：2018-12-18
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Brian K. Whiteley , Sreekantha Ratna Kumar , Anupama Kandhi Ramachandra Reddy
IPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, X, Y, Z, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20230098244A1
公开(公告)日：2023-03-30
申请号：US17699944
申请日：2022-03-21
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tsair Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11447466B2
公开(公告)日：2022-09-20
申请号：US16635593
申请日：2018-08-03
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Tasir Shamsul Haque , Brian K. Whiteley , John L. Gilmore
IPC分类号： A61K31/4545 , A61P29/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20200308172A1
公开(公告)日：2020-10-01
申请号：US16955097
申请日：2018-12-18
发明人： Alaric J. Dyckma , Dharmpal S. Dodd , Christopher P. Mussari , John P. Gilmore , Tasir Shmsul Haque , Trevor C. Sherwood , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Warangal , Srinivasan Kunchythapatham Duraisamy , Subramanya Hegde , Rushith Kumar Anumula , Pitani Veera Venkata Sriniva
IPC分类号： C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D405/14 , C07D487/04 , C07D453/02 , C07D491/08 , C07D401/04 , C07D401/10
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US12030878B2
公开(公告)日：2024-07-09
申请号：US16772192
申请日：2018-12-14
IPC分类号： C07D471/04 , C07D209/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D453/02 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/22
CPC分类号： C07D471/04 , C07D209/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D453/02 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/22
摘要： Disclosed are compounds of Formula (I) (I) N-oxides, or salts thereof, wherein R1, G, A, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11739098B2
公开(公告)日：2023-08-29
申请号：US17699944
申请日：2022-03-21
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tasir Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I)
or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.-
公开(公告)号：US11420958B2
公开(公告)日：2022-08-23
申请号：US16955314
申请日：2018-12-19
发明人： Alaric J. Dyckman , Christopher P. Mussari , Tasir Shamsul Haque , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Subramanya Hegde , Anupama Kandhi Ramachandra Reddy , Rushith Kumar Anumula
IPC分类号： C07D403/12 , C07D209/12 , C07D209/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20210087174A1
公开(公告)日：2021-03-25
申请号：US16955314
申请日：2018-12-19
发明人： Alaric J. Dyckman , Christopher P. Mussari , Tasir Shamsul Haque , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Subramanya Hegde , Anupama Kandhi Ramachandra Reddy , Rushith Kumar Anumula
IPC分类号： C07D403/12 , C07D401/14 , C07D209/12 , C07D401/12 , C07D487/04 , C07D401/04 , C07D413/14 , C07D413/12 , C07D405/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D471/08 , C07D495/04 , C07D519/00 , C07D513/04 , C07D401/10 , C07D403/10 , C07D413/10 , C07D209/14 , C07D409/14
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11998537B2
公开(公告)日：2024-06-04
申请号：US17287735
申请日：2019-10-22
IPC分类号： A61K31/4545 , A61K47/54 , A61K47/55
CPC分类号： A61K31/4545 , A61K47/54 , A61K47/55
摘要： Disclosed are compounds of Formula (I) Formula (I) N-oxides, or salts thereof, wherein G1, G2, L, R1a, R1b, R4, R5, n, m, x, and y are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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