公开(公告)号：US20100063569A1

公开(公告)日：2010-03-11

申请号：US12541461

申请日：2009-08-14

申请人： Bruce A. Tockman ,  Timothy R. Jackson ,  Brendan E. Koop ,  Lili Liu ,  Kimberly A. Morris ,  David J. Parins

发明人： Bruce A. Tockman ,  Timothy R. Jackson ,  Brendan E. Koop ,  Lili Liu ,  Kimberly A. Morris ,  David J. Parins

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： A medical lead includes a lead body having at least one conductor extending from a proximal end of the lead body to a distal end of the lead body. The proximal end is adapted to be connected to a pulse generator, and the distal end includes a curved portion. One or more electrodes are operatively connected to the at least one conductor and coupled to the curved portion of the lead body. At least a portion of each of the one or more electrodes includes an arrangement of interconnected, spaced-apart elements that are selectively configured to allow the one or more electrodes to conform to contours of the curved portion during and after implantation of the medical lead.

摘要翻译： 医疗用引线包括具有至少一个导体的引线体，导体从引线主体的近端延伸到引线主体的远端。 近端适于连接到脉冲发生器，并且远端包括弯曲部分。 一个或多个电极可操作地连接到至少一个导体并且耦合到引线主体的弯曲部分。 一个或多个电极中的每一个的至少一部分包括互连的间隔开的元件的布置，其被选择性地配置成允许一个或多个电极在植入医疗引线期间和之后使其符合弯曲部分的轮廓。

公开(公告)号：US08655458B2

公开(公告)日：2014-02-18

申请号：US12541461

申请日：2009-08-14

申请人： Bruce A. Tockman ,  Timothy R. Jackson ,  Brendan E. Koop ,  Lili Liu ,  Kimberly A. Morris ,  David J. Parins

发明人： Bruce A. Tockman ,  Timothy R. Jackson ,  Brendan E. Koop ,  Lili Liu ,  Kimberly A. Morris ,  David J. Parins

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： A medical lead includes a lead body having at least one conductor extending from a proximal end of the lead body to a distal end of the lead body. The proximal end is adapted to be connected to a pulse generator, and the distal end includes a curved portion. One or more electrodes are operatively connected to the at least one conductor and coupled to the curved portion of the lead body. At least a portion of each of the one or more electrodes includes an arrangement of interconnected, spaced-apart elements that are selectively configured to allow the one or more electrodes to conform to contours of the curved portion during and after implantation of the medical lead.

摘要翻译： 医疗用引线包括具有至少一个导体的引线体，导体从引线主体的近端延伸到引线主体的远端。 近端适于连接到脉冲发生器，并且远端包括弯曲部分。 一个或多个电极可操作地连接到至少一个导体并且耦合到引线主体的弯曲部分。 一个或多个电极中的每一个的至少一部分包括互连的间隔开的元件的布置，其被选择性地配置成允许一个或多个电极在植入医疗引线期间和之后使其符合弯曲部分的轮廓。

公开(公告)号：US07672735B2

公开(公告)日：2010-03-02

申请号：US11346096

申请日：2006-02-02

申请人： Brendan E. Koop ,  Paul E. Zarembo

发明人： Brendan E. Koop ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： Methods of implanting a two-part cardiac lead in a heart are disclosed. The two-part cardiac lead has inner and outer portions and a pin. The inner and outer lead portions are separately advanced to a location of interest within the vasculature of a patient. The pin is attached to a proximal end of the inner lead portion and can provide a connection between the inner and outer lead portions.

摘要翻译： 公开了将两部分心脏铅引入心脏的方法。 两部分心脏引线具有内部和外部部分以及引脚。 内部和外部引线部分分别前进到患者脉管系统内的感兴趣位置。 销固定在内引导部分的近端上，并且可以在内引线部分和外引线部分之间提供连接。

公开(公告)号：US20100042195A1

公开(公告)日：2010-02-18

申请号：US12508322

申请日：2009-07-23

申请人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

发明人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0568

摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

公开(公告)号：US20080183259A1

公开(公告)日：2008-07-31

申请号：US11668926

申请日：2007-01-30

申请人： Mark J. Bly ,  Randy W. Westlund ,  Ronald W. Heil ,  Brendan E. Koop ,  Paul E. Zarembo

发明人： Mark J. Bly ,  Randy W. Westlund ,  Ronald W. Heil ,  Brendan E. Koop ,  Paul E. Zarembo

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N1/0558 ,  A61N1/36114

摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes an expandable distal portion having one or more spirals for securing and stabilizing the lead within the vessel.

摘要翻译： 描述了用于从相邻容器中经血管刺激神经，肌肉或其他组织的医用电引线。 引线包括具有一个或多个螺旋的可扩展远端部分，用于固定和稳定血管内的引线。

公开(公告)号：US20070265692A1

公开(公告)日：2007-11-15

申请号：US11748614

申请日：2007-05-15

申请人： Brendan E. Koop ,  Shamim M. Malik

发明人： Brendan E. Koop ,  Shamim M. Malik

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0568 ,  A61N2001/0585

摘要： The present invention relates to a porous surface electrode including a capacitive layer and a method of making the same. The porous surface electrode of the present invention includes a more thin capacitive coating that preserves the underlying structure of the porous surface. By controlling one or more processing parameters the average thickness and surface morphology of the capacitive coating can be controlled.

摘要翻译： 本发明涉及一种包括电容层的多孔表面电极及其制造方法。 本发明的多孔表面电极包括保持多孔表面的下面结构的更薄的电容涂层。 通过控制一个或多个加工参数，可以控制电容涂层的平均厚度和表面形态。

公开(公告)号：US08406895B2

公开(公告)日：2013-03-26

申请号：US12907657

申请日：2010-10-19

申请人： Blair Erbstoeszer ,  Brendan E. Koop

发明人： Blair Erbstoeszer ,  Brendan E. Koop

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/086

摘要： An implantable medical device lead includes an insulative lead body, an outer conductive coil extending through the lead body, and an inner conductive coil extending coaxially with the outer conductive coil. The outer conductive coil is coupled to a proximal electrode at a distal end of the outer conductive coil, and the inner conductive coil is coupled to a distal electrode at a distal end of the inner conductive coil. A cooling assembly is thermally coupled to the distal electrode to dissipate heat generated at the distal electrode during exposure to magnetic resonance imaging (MRI) fields.

摘要翻译： 可植入医疗器件引线包括绝缘引线体，延伸穿过引线体的外部导电线圈和与外部导电线圈同轴延伸的内部导电线圈。 外部导电线圈在外部导电线圈的远端处连接到近端电极，并且内部导电线圈联接到内部导电线圈的远端处的远端电极。 冷却组件热耦合到远端电极以消散在暴露于磁共振成像（MRI）场期间在远端电极处产生的热量。

公开(公告)号：US08321035B2

公开(公告)日：2012-11-27

申请号：US13160045

申请日：2011-06-14

申请人： Brendan E. Koop

发明人： Brendan E. Koop

IPC分类号： A61N1/00

CPC分类号： A61N1/0565 ,  A61N2001/0585 ,  Y10T29/49208

摘要： A medical device lead includes an insulative lead body, a conductor extending through the lead body from a proximal end to a distal end, and an electrode electrically connected to the conductor. The proximal end is adapted to be electrically connected to a pulse generator. The electrode includes a plurality of electrode modules mechanically coupled in a stack of electrode modules. Each electrode module includes a plurality of layers that define substantially similar sized pores such that the stack of electrode modules includes an array of the substantially similar sized pores.

摘要翻译： 医疗装置引线包括绝缘引线体，从近端延伸穿过引线主体到远端的导体，以及与导体电连接的电极。 近端适于电连接到脉冲发生器。 电极包括机械耦合在电极模块堆叠中的多个电极模块。 每个电极模块包括多个层，其限定基本相似的尺寸的孔，使得电极模块的堆叠包括基本相似尺寸的孔的阵列。

公开(公告)号：US08160721B2

公开(公告)日：2012-04-17

申请号：US12508322

申请日：2009-07-23

申请人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

发明人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N1/0568

摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

公开(公告)号：US20120046721A1

公开(公告)日：2012-02-23

申请号：US13160045

申请日：2011-06-14

申请人： Brendan E. Koop

发明人： Brendan E. Koop

IPC分类号： A61N1/00 ,  H01R43/20

CPC分类号： A61N1/0565 ,  A61N2001/0585 ,  Y10T29/49208

摘要： A medical device lead includes an insulative lead body, a conductor extending through the lead body from a proximal end to a distal end, and an electrode electrically connected to the conductor. The proximal end is adapted to be electrically connected to a pulse generator. The electrode includes a plurality of electrode modules mechanically coupled in a stack of electrode modules. Each electrode module includes a plurality of layers that define substantially similar sized pores such that the stack of electrode modules includes an array of the substantially similar sized pores.

摘要翻译： 医疗装置引线包括绝缘引线体，从近端延伸穿过引线主体到远端的导体，以及与导体电连接的电极。 近端适于电连接到脉冲发生器。 电极包括机械耦合在电极模块堆叠中的多个电极模块。 每个电极模块包括多个层，其限定基本相似的尺寸的孔，使得电极模块的堆叠包括基本相似尺寸的孔的阵列。