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1.发明申请Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 审中-公开新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US20060178400A1
公开(公告)日：2006-08-10
申请号：US11268698
申请日：2005-11-07
申请人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
发明人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D211/68
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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2.发明申请NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 失效新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20070225332A1
公开(公告)日：2007-09-27
申请号：US11675410
申请日：2007-02-15
申请人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
发明人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/42 , C07D417/14 , C07D413/02
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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3.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 失效乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08748627B2
公开(公告)日：2014-06-10
申请号：US11675410
申请日：2007-02-15
申请人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
发明人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
IPC分类号： A61K31/427 , A61K31/433 , A61K31/4245 , A61K31/4439 , A61K31/444 , C07D417/12 , C07D417/14 , C07D417/04 , C07D413/12 , C07D413/14
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US20060287356A1
公开(公告)日：2006-12-21
申请号：US11509383
申请日：2006-08-24
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： C07D498/02 , A61K31/4743
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
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5.发明申请Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂公开(公告)号：US20050038068A1
公开(公告)日：2005-02-17
申请号：US10847144
申请日：2004-05-17
申请人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
发明人： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC分类号： A61K31/4743 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
摘要翻译： 本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途 。
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公开(公告)号：US20070219251A1
公开(公告)日：2007-09-20
申请号：US11675406
申请日：2007-02-15
申请人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing Sham
发明人： Yu Gui Gu , Xiangdong Xu , Moshe Weitzberg , Hing Sham
IPC分类号： A61K31/4439 , A61K31/426 , C07D417/02
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
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7.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 有权乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US07928243B2
公开(公告)日：2011-04-19
申请号：US11950692
申请日：2007-12-05
申请人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
发明人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
IPC分类号： A61K31/426 , C07D277/34
CPC分类号： C07D277/34 , C07C233/18 , C07C233/22
摘要： The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
摘要翻译： 本发明涉及式（I）的化合物：也可用于治疗或预防代谢疾病或病症的药物组合物和方法。
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8.发明申请NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 有权新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20080161368A1
公开(公告)日：2008-07-03
申请号：US11950692
申请日：2007-12-05
申请人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
发明人： Yu Gui Gu , Richard F. Clark , Qun Li , Moshe Weitzberg , Hing Sham
IPC分类号： A61K31/426 , A61P3/00 , C07C235/00 , C07D277/00 , A61K31/165
CPC分类号： C07D277/34 , C07C233/18 , C07C233/22
摘要： The present invention relates to compounds of formula (I): Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
摘要翻译： 本发明涉及式（I）的化合物：也可用于治疗或预防代谢疾病或病症的药物组合物和方法。
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公开(公告)号：US20050070712A1
公开(公告)日：2005-03-31
申请号：US10671723
申请日：2003-09-26
申请人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
发明人： Christi Kosogof , Bo Liu , Gang Liu , Mei Liu , Lissa Nelson , Michael Serby , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P3/00 , C07D239/48 , C07D405/12 , C07D409/12 , C07D43/04
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
摘要翻译： 本发明涉及式（I）化合物或其治疗上合适的盐或前药，该化合物的制备，含该化合物的组合物以及该化合物在预防或治疗由生长素释放肽（包括厌食症）调节的疾病中的用途 ，癌症恶病质，进食障碍，身体组成，体重增加，肥胖和糖尿病年龄相关的下降。
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公开(公告)号：US20060173050A1
公开(公告)日：2006-08-03
申请号：US11337862
申请日：2006-01-23
申请人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
发明人： Gang Liu , Hing Sham , Bruce Szczepankiewicz , Zhili Xin , Hongyu Zhao , Michael Serby , Bo Liu , Mei Liu
IPC分类号： C07D213/84 , A61K31/44
CPC分类号： C07D417/12 , C07D213/73 , C07D213/81 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
摘要翻译： 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。
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