公开(公告)号：US07133712B2

公开(公告)日：2006-11-07

申请号：US10404702

申请日：2003-04-01

申请人： Bruce E. Cohan ,  Geun Sig Cha ,  Mark E. Meyerhoff ,  Hakhyun Nam ,  Donald E. Gillespie ,  Gang Cui ,  Jong Sik Kim ,  Zvi Flanders

发明人： Bruce E. Cohan ,  Geun Sig Cha ,  Mark E. Meyerhoff ,  Hakhyun Nam ,  Donald E. Gillespie ,  Gang Cui ,  Jong Sik Kim ,  Zvi Flanders

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： C12Q1/006 ,  A61B5/1486 ,  A61B2562/0295 ,  C12Q1/32 ,  C12Q1/54 ,  G01N27/3272 ,  G01N33/528 ,  G01N2001/1056 ,  G01N2001/149 ,  G01N2035/0465 ,  Y10T436/144444

摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.

公开(公告)号：US09512458B2

公开(公告)日：2016-12-06

申请号：US12740016

申请日：2008-10-24

申请人： Gang Cui ,  Jae Hyun Yoo ,  Ju Yong Kim ,  Keun Ki Kim ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Jae Hyun Yoo ,  Ju Yong Kim ,  Keun Ki Kim ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： C12Q1/00 ,  G01N27/327 ,  B01L3/00

CPC分类号： C12Q1/006 ,  B01L3/5027 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N27/3272

摘要： Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.

摘要翻译： 公开了一种具有样品导入通道的电化学生物传感器，其中采用绝缘体均匀且准确地引入少量样品并调节工作电极的面积，从而保证了样品的准确定量分析。 在样品入口处提供样品收集屏障，生物传感器允许以更高的精度引入样品并以更高的再现性和可靠性进行分析。

公开(公告)号：US06350524B1

公开(公告)日：2002-02-26

申请号：US09477173

申请日：2000-01-04

申请人： Jin Seo Lee ,  Hyo Jung Yoon ,  Gang Cui ,  Jae Ho Shin ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Jin Seo Lee ,  Hyo Jung Yoon ,  Gang Cui ,  Jae Ho Shin ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： B32B2740

CPC分类号： G01N27/333 ,  G01N27/40 ,  Y10T428/3158 ,  Y10T428/31598 ,  Y10T428/31609

摘要： The present invention relates to chloride-selective electrodes which comprise insoluble metal salt layer and a protecting membrane formed of hydrophilic polyurethane thereon, wherein the hydrophilic polyurethane coated chloride-selective electrodes show fast activation and response time and are usefully employed to accurately measure the chloride by reducing the interference from bromide and iodide or preventing the surface of the electrode from protein adsorption.

摘要翻译： 本发明涉及包含不溶性金属盐层和由其上的亲水性聚氨酯形成的保护膜的氯化物选择性电极，其中亲水性聚氨酯涂覆的氯化物选择性电极显示快速的活化和响应时间，并且有用地用于通过 减少溴化物和碘化物的干扰，或阻止电极表面的蛋白质吸附。

公开(公告)号：US08377272B2

公开(公告)日：2013-02-19

申请号：US12529008

申请日：2008-02-26

申请人： Keun Ki Kim ,  Moon Hwan Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Keun Ki Kim ,  Moon Hwan Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27/327

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  G01N33/48771 ,  G01N2035/00851

摘要： Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 公开了一种可与电化学生物传感器一起使用的电化学生物传感器测量装置。 生物传感器测量装置包括电连接部分，其在将生物传感器插入其中时与生物传感器的电极电连接;以及连接器，具有其中至少一个光吸收或反射路径顺序地包括发光 - 提供生产批次信息识别部分检测器单元以识别记录在生物传感器中的生产批次信息。 当将电化学生物传感器插入到测量装置中时，电化学生物传感器测量装置可以自动识别以色调或孔痕形式编码的生物传感器的生产批量信息，从而避免需要手动输入生产批次信息 的生物传感器。 因此，可以减少当用户亲自输入生产批量信息时发生的不便和错误频率，结果可以方便和准确地获取测量值。

公开(公告)号：US08314613B2

公开(公告)日：2012-11-20

申请号：US12672596

申请日：2008-02-26

申请人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01V3/00

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/004

摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置 。 电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上 安装技术（SMT）。 不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。 此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是 方便准确地获取。

公开(公告)号：US20100126882A1

公开(公告)日：2010-05-27

申请号：US12530128

申请日：2008-02-26

申请人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27/26

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/1486 ,  A61B2562/08 ,  B01L3/545 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/0825 ,  G01N2035/00752 ,  G01N2035/00811

摘要： Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that the frequency of inconvenience and error that occur when a user personally inputs the production lot information of the biosensor can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 本文公开了一种电化学生物传感器测量装置，其包括至少两个光电二极管，用于以顺序方式以规则的时间间隔发射光束，同时插入电化学生物传感器，以及用于感测发射的光束的检测器，从而识别生产 记录在电化学生物传感器上的生产批次信息识别部分上的批次信息。 因此，该设备具有经济上的优点，即不需要高价格的光学滤波器来检测由生物传感器中记录的生产识别信息吸收或反射的光，以及复杂的软件算法来恢复生产批次信息。 此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生物传感器的生产批次信息时发生的不便和错误的频率，结果是测量值可以 方便，准确地获得。

公开(公告)号：US08338183B2

公开(公告)日：2012-12-25

申请号：US12375635

申请日：2006-07-29

申请人： Hakhyun Nam ,  Fenghua Zhang ,  Soon Hye Yang ,  Bo Kyeong Kang ,  Gang Cui ,  Moon Hee Choi ,  Joung Su Lee ,  Geun Sig Cha

发明人： Hakhyun Nam ,  Fenghua Zhang ,  Soon Hye Yang ,  Bo Kyeong Kang ,  Gang Cui ,  Moon Hee Choi ,  Joung Su Lee ,  Geun Sig Cha

IPC分类号： G01N33/50 ,  G01N33/48

CPC分类号： G01N33/723 ,  G01N33/5308 ,  G01N33/5438

摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.

摘要翻译： 本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中 糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。 本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置 。 此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变 电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

公开(公告)号：US20100032321A1

公开(公告)日：2010-02-11

申请号：US12529008

申请日：2008-02-26

申请人： Keun Ki Kim ,  Moon Hwan Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Keun Ki Kim ,  Moon Hwan Kim ,  Jae Hyun Yoo ,  Gang Cui ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27/26

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  G01N33/48771 ,  G01N2035/00851

摘要： Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 公开了一种可与电化学生物传感器一起使用的电化学生物传感器测量装置。 生物传感器测量装置包括电连接部分，其在将生物传感器插入其中时与生物传感器的电极电连接;以及连接器，具有其中至少一个光吸收或反射路径顺序地包括发光 - 提供生产批次信息识别部分检测器单元以识别记录在生物传感器中的生产批次信息。 当将电化学生物传感器插入到测量装置中时，电化学生物传感器测量装置可以自动识别以色调或孔痕形式编码的生物传感器的生产批次信息，从而避免了手动输入生产批次信息的需要 的生物传感器。 因此，可以减少当用户亲自输入生产批量信息时发生的不便和错误频率，结果可以方便和准确地获取测量值。

公开(公告)号：US06726818B2

公开(公告)日：2004-04-27

申请号：US09904930

申请日：2001-07-13

申请人： Gang Cui ,  Jae Hyun Yoo ,  Byung Wook Woo ,  Moon Hwan Kim ,  Hyun Joon Oh ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Jae Hyun Yoo ,  Byung Wook Woo ,  Moon Hwan Kim ,  Hyun Joon Oh ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01N27327

CPC分类号： G01N27/3272 ,  C12Q1/004 ,  C12Q1/006 ,  C12Q1/26 ,  G01N30/90 ,  G01N33/491

摘要： Disclosed is a porous membrane built-in biosensor comprising (a) at least one substrate; (b) an electrode layer patterned on the substrate, consisting of an electrode system and a circuit connector; (c) an insulator, formed on parts of the electrode layer, for electrically separating the electrode system from a circuit connector; and (d) a porous membrane via the insulator on the electrode system, wherein, when a whole blood sample is introduced to the biosensor, the whole blood sample is separated into its components during the chromatographic motion through the porous membrane so that only blood plasma can be contacted with the electrode system. The porous membrane built-in biosensor is provided with a sample inlet, which allows samples to be introduced in a constant quantity to the biosensors porous membranes without pretreatment.

摘要翻译： 公开了一种内置多孔膜的生物传感器，其包含（a）至少一个基底; （b）在基板上图案化的电极层，由电极系统和电路连接器组成; （c）形成在所述电极层的部分上的用于将所述电极系统与电路连接器电分离的绝缘体; 和（d）通过电极系统上的绝缘体的多孔膜，其中当将全血样品引入生物传感器时，在通过多孔膜进行色谱运动期间将全血样品分离成其组分，使得仅血浆 可以与电极系统接触。 多孔膜内置生物传感器具有样品入口，其允许将样品以恒定量引入生物传感器多孔膜而无需预处理。

公开(公告)号：US20110210726A1

公开(公告)日：2011-09-01

申请号：US12672596

申请日：2008-02-26

申请人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

发明人： Gang Cui ,  Keun Ki Kim ,  Dong Hoon Han ,  Moon Hwan Kim ,  Hakhyun Nam ,  Geun Sig Cha

IPC分类号： G01R33/02

CPC分类号： G01N33/48771 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/004

摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.

摘要翻译： 公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置 。 电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上 安装技术（SMT）。 不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。 此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是 方便准确地获取。