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1.发明授权公开(公告)号：US06196993B1
公开(公告)日：2001-03-06
申请号：US09294720
申请日：1999-04-19
申请人： Bruce E. Cohan , Howard Diamond
发明人： Bruce E. Cohan , Howard Diamond
IPC分类号： A61K922
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051 , Y10S977/904
摘要： An ophthalmic insert and method for sustained release of medication to the eye are provided. The insert includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The insert further includes a collarette connected to the body portion and sized to rest on the exterior of the lacrimal punctum, the collarette having a pore provided therein. A reservoir is contained at least partially within the body portion and in fluid communication with the pore, wherein the reservoir is designed to store and release medication through the pore and onto the eye over time in a controlled manner while the insert is positioned in the eyelid. Preferably, the pore is constructed with a specific geometry appropriate to control the rate of release of the medication onto the eye.
摘要翻译： 提供了一种用于将药物持续释放至眼睛的眼科插入物和方法。 插入物包括尺寸适于穿过泪点并被定位在眼睑的泪小管内的体部。 插入件还包括连接到主体部分并且尺寸适于搁置在泪点的外部上的小针coll，所述coll tte具有设置在其中的孔。 储存器至少部分地容纳在主体部分内并且与孔流体连通，其中储存器被设计成在受控的方式下随着时间的流逝通过孔存储和释放药物，同时将插入物定位在眼睑中 。 优选地，孔被构造成具有适合于控制药物释放到眼睛上的速率的特定几何形状。
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公开(公告)号：US4952300A
公开(公告)日：1990-08-28
申请号：US244713
申请日：1988-09-14
申请人： Howard Diamond
发明人： Howard Diamond
IPC分类号： A61C19/04 , G01N27/30 , G01N27/403
CPC分类号： A61C19/04 , G01N27/4035
摘要： An ion sensitive electrode device and method of its use in analytical and clinical chemistry are provided for measuring the concentration of an ionizable analyte contained in an aqueous medium. The device with external circuit means includes an electrode pair adapted to be placed in electrochemical contact with the medium. The electrode pair includes a polarographically active base metal/metal oxide working electrode and a reference electrode. The external circuit means is adapted to measure the voltage generated by the electrode pair in open circuit and to measure the closed circuit current flow at a preselected impedance and including means for comparing said voltage and current flow values with predetermined reference standards to provide a third value representative of said analyte concentration.
摘要翻译： 提供了用于分析和临床化学中的离子敏感电极装置及其方法，用于测量水性介质中所含的可离子化分析物的浓度。 具有外部电路装置的装置包括适于与介质电化学接触的电极对。 电极对包括极谱极化的贱金属/金属氧化物工作电极和参考电极。 外部电路装置适于测量由开路中的电极对产生的电压并且以预选阻抗测量闭路电流，并且包括用于将所述电压和电流流量值与预定参考标准进行比较以提供第三值 代表所述分析物浓度。
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公开(公告)号：US4342964A
公开(公告)日：1982-08-03
申请号：US121341
申请日：1980-02-14
IPC分类号： G01N27/403 , G01N27/416 , G01N27/42
CPC分类号： G01N27/4165
摘要： A method and apparatus for measuring a chemical characteristic of a liquid such as its hydrogen ion activity or pH value. A disposable cassette having a reference and indicating electrode therein utilizes the same solution to first calibrate the device and then as an electrolytic bridge from the liquid sample to the reference electrode. The solution has the properties of a buffered pH and also provides a stable electrochemical environment around the reference electrode. In one embodiment, a volume of a liquid sample is placed into a capillary tube and the open end of the tube is then placed over the indicating electrode immersed in the solution. The electrical potential between the indicating electrode and the spaced reference electrode in the electrolyte solution provides a measurement of the pH value of the liquid when compared to the calibration potential previously measured without the liquid sample contacting the indicating electrode.
摘要翻译： 用于测量液体的化学特性如其氢离子活性或pH值的方法和装置。 其中具有参考电极和指示电极的一次性盒子利用相同的溶液来首先校准装置，然后作为从液体样品到参考电极的电解桥。 该溶液具有缓冲pH的性质，并且还在参考电极周围提供稳定的电化学环境。 在一个实施例中，将一定体积的液体样品放入毛细管中，然后将管的开口端置于浸在溶液中的指示电极上。 当电极溶液中的指示电极和间隔的参考电极之间的电位提供了与先前测量的校准电位相比较时的液体pH值的测量，而液体样品没有接触指示电极。
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公开(公告)号：US06264615B1
公开(公告)日：2001-07-24
申请号：US09487753
申请日：2000-01-19
申请人： Howard Diamond , Donald L. Musinski
发明人： Howard Diamond , Donald L. Musinski
IPC分类号： A61B508
CPC分类号： A61B5/14542 , A61B5/1473
摘要： A method and apparatus for diagnosing the presence and extent of halitosis activity are disclosed. A method includes assaying for the presence of sulfides on the surface of a subject's tongue in order to determine the concentrations of sulfides in the fluids.
摘要翻译： 公开了一种用于诊断口臭活性的存在和程度的方法和装置。 一种方法包括测定受试者舌头表面上硫化物的存在，以确定流体中硫化物的浓度。
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公开(公告)号：US4272245A
公开(公告)日：1981-06-09
申请号：US965901
申请日：1978-12-04
IPC分类号： G01N27/28 , G01N27/403 , G01N27/416 , G01N27/56
CPC分类号： G01N27/4165
摘要： A method and apparatus for measuring a chemical characteristic of a liquid such as its hydrogen ion activity or pH value. A disposable cassette having a reference and indicating electrode therein utilizes the same solution to first calibrate the device and then as an electrolytic bridge from the liquid sample to the reference electrode. The solution has the properties of a buffered pH and also provides a stable electrochemical environment around the reference electrode. In one embodiment, a volume of a liquid sample is placed into a capillary tube and the open end of the tube is then placed over the indicating electrode immersed in the solution. The electrical potential between the indicating electrode and the spaced reference electrode in the electrolyte solution provides a measurement of the pH value of the liquid when compared to the calibration potential previously measured without the liquid sample contacting the indicating electrode.
摘要翻译： 用于测量液体的化学特性如其氢离子活性或pH值的方法和装置。 其中具有参考电极和指示电极的一次性盒子利用相同的溶液来首先校准装置，然后作为从液体样品到参考电极的电解桥。 该溶液具有缓冲pH的性质，并且还在参考电极周围提供稳定的电化学环境。 在一个实施例中，将一定体积的液体样品放入毛细管中，然后将管的开口端置于浸在溶液中的指示电极上。 当电极溶液中的指示电极和间隔的参考电极之间的电势提供了与先前测量的校准电位相比较时的液体pH值的测量，而液体样品没有接触指示电极。
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6.发明授权
公开(公告)号：US5275161A
公开(公告)日：1994-01-04
申请号：US848086
申请日：1992-03-09
申请人： Bruce B. Graves , Howard Diamond
发明人： Bruce B. Graves , Howard Diamond
CPC分类号： A61B5/14542 , A61B5/1473 , A61B5/4547
摘要： A method of and apparatus for diagnosing the presence and extent of disease activity within a periodontal pocket. A dual electrode probe having a first, working silver electrode and a second, reference silver/silver chloride electrode is inserted into the pocket to take data measurements of the electrochemical potential between the electrodes while they are immersed in the fluid contained in the periodontal sulcus. The strength of the potential reflects the amount of sulfides within the sulcus fluid and reflects the presence and extent of disease therewithin.
摘要翻译： 用于诊断牙周袋内疾病活动的存在和程度的方法和装置。 将具有第一工作银电极和第二参考银/氯化银电极的双电极探针插入到口袋中，以便在将它们浸入包含在牙周中的流体中时对电极之间的电化学电位进行数据测量。 潜在的力量反映了唾液中硫化物的量，并反映了其中疾病的存在和程度。
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公开(公告)号：US4798655A
公开(公告)日：1989-01-17
申请号：US27846
申请日：1987-03-19
申请人： Howard Diamond
发明人： Howard Diamond
CPC分类号： G01N27/4035 , A61C19/04
摘要： An ion sensitive electrode device and method of its use in analytical and clinical chemistry are provided for measuring the concentration of an ionizable analyte contained in an aqueous medium. The device with external circuit means includes an electrode pair adapted to be placed in electrochemical contact with the medium. The electrode pair includes a polarographically active base metal/metal oxide working electrode and a reference electrode. The external circuit means is adapted to measure the voltage generated by the electrode pair in open circuit and to measure the closed circuit current flow at a preselected impedance and including means for comparing said voltage and current flow values with predetermined reference standards to provide a third value representative of said analyte concentration.
摘要翻译： 提供了用于分析和临床化学中的离子敏感电极装置及其方法，用于测量水性介质中所含的可离子化分析物的浓度。 具有外部电路装置的装置包括适于与介质电化学接触的电极对。 电极对包括极谱极化的贱金属/金属氧化物工作电极和参考电极。 外部电路装置适于测量由开路中的电极对产生的电压并且以预选阻抗测量闭路电流，并且包括用于将所述电压和电流流量值与预定参考标准进行比较以提供第三值 代表所述分析物浓度。
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