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公开(公告)号：US06266563B1
公开(公告)日：2001-07-24
申请号：US09391026
申请日：1999-09-07
IPC分类号： A61N139
CPC分类号： A61N1/3918 , A61N1/3937 , A61N1/3943
摘要： An implantable system for the antitachycardia pacing of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. At least one of the primary electrodes is configured for positioning through the coronary sinus ostium and in a vein on the left surface of the patient's heart.
摘要翻译： 用于需要这种治疗的患者心脏的抗心动过速起搏的可植入系统包括多个初级电极，电源和控制电路。 主电极中的至少一个构造成用于定位穿过患者心脏的左侧表面的冠状窦口和静脉。
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公开(公告)号：US06275730B1
公开(公告)日：2001-08-14
申请号：US09390442
申请日：1999-09-07
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3918 , A61N1/3943
摘要： An implantable system for the cardioversion of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. Preferably, at least one auxiliary electrode is also included. The plurality of primary electrodes are configured for delivering a cardiversion pulse along a predetermined current pathway in a first portion of the heart, the current pathway defining a weak field area in a second portion of the heart.
摘要翻译： 用于需要这种治疗的患者的心脏的心脏复律的可植入系统包括多个初级电极，电源和控制电路。 优选地，还包括至少一个辅助电极。 多个主电极被配置用于沿着心脏的第一部分中的预定电流通路输送引导脉冲，该电流通路在心脏的第二部分中限定弱磁场区域。
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3.发明授权
公开(公告)号：US5978705A
公开(公告)日：1999-11-02
申请号：US39143
申请日：1998-03-13
CPC分类号： A61N1/3937 , A61N1/3918 , A61N1/3943
摘要： An implantable system for the defibrillation or cardioversion of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. Preferably, at least one auxiliary electrode is also included. The plurality of primary electrodes are configured for delivering a defibrillation pulse along a predetermined current pathway in a first portion of the heart, the current pathway defining a weak field area in a second portion of the heart. The at least one auxiliary electrode is configured for delivering an auxiliary pulse to the a portion of the heart where the primary shock field intensity is at or near a minimum. The control circuit is operatively associated with the primary electrodes, the auxiliary electrode, and the power supply, with the control circuit configured for delivering a cardioversion sequence comprising an auxiliary pulse sufficient to induce a cessation of propagation in the weak field area through the auxiliary electrode, followed by a defibrillation pulse through the primary electrodes delivered during the cessation of propagation in the weak field area.
摘要翻译： 用于需要这种治疗的患者的心脏的除颤或心脏复律的可植入系统包括多个初级电极，电源和控制电路。 优选地，还包括至少一个辅助电极。 多个主电极被配置用于沿心脏的第一部分中的预定电流通路输送除颤脉冲，该电流通路在心脏的第二部分中限定弱磁场区域。 所述至少一个辅助电极被配置为将辅助脉冲传送到心脏的一部分，其中主要的冲击电场强度处于或接近最小值。 所述控制电路与所述主电极，所述辅助电极和所述电源可操作地相关联，所述控制电路被配置用于传送包括辅助脉冲的复律序列，所述辅助脉冲足以引起通过所述辅助电极在所述弱磁场区域中的传播停止 ，然后通过在弱磁场区域中传播停止期间传递的主电极的除颤脉冲。
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4.发明授权Method and apparatus for delivering an optimum shock duration in treating cardiac arrhythmias 失效用于在治疗心律失常中提供最佳休克持续时间的方法和装置公开(公告)号：US06643545B2
公开(公告)日：2003-11-04
申请号：US09915898
申请日：2001-07-26
IPC分类号： A61N139
CPC分类号： A61N1/3937
摘要： The present invention provides apparatus and methods for delivering an optimum electrical shock in treating cardiac arrhythmias. The apparatus comprises means for producing an electrical waveform signal at least two electrodes The voltage or current of the signal is then detected to determine the signal time constant. The signal time constant is then used in conjunction with a model time constant to determine when the peak amplitude is reached. The waveform is then interrupted when the peak amplitude is reached. Also provided are methods of selecting a cardiac defibrillator by measuring the impedance of implanted electrodes and then selecting a defibrillator having a capacitor which provides an RC time constant equal to that of a model time constant.
摘要翻译： 本发明提供了用于在治疗心律失常中递送最佳电击的装置和方法。 该装置包括用于在至少两个电极产生电波形信号的装置。然后检测信号的电压或电流以确定信号时间常数。 然后将信号时间常数与模型时间常数结合使用以确定何时达到峰值振幅。 当达到峰值振幅时，波形中断。 还提供了通过测量注入电极的阻抗然后选择具有提供等于模型时间常数的RC时间常数的电容器的除颤器来选择心脏除颤器的方法。
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5.发明授权Method and apparatus for delivering an optimum shock duration in treating cardiac arrhythmias 失效用于在治疗心律失常中提供最佳休克持续时间的方法和装置
公开(公告)号：US5540723A
公开(公告)日：1996-07-30
申请号：US132373
申请日：1993-10-06
IPC分类号： A61N1/39
CPC分类号： A61N1/3937
摘要： The present invention provides apparatus and methods for delivering an optimum electrical shock in treating cardiac arrhythmias. The invention comprises apparatus for producing an electrical waveform signal at least at two electrodes. The voltage or current of the signal is then detected to determine the signal time constant. The signal time constant is then used in conjunction with a model time constant to determine when the peak amplitude is reached. The waveform is then interrupted when the peak amplitude is reached. Also provided are methods of selecting a cardiac defibrillator by measuring the impedance of implanted electrodes and then selecting a defibrillator having a capacitor which provides an RC time constant equal to that of a model time constant.
摘要翻译： 本发明提供了用于在治疗心律失常中递送最佳电击的装置和方法。 本发明包括至少在两个电极产生电波形信号的装置。 然后检测信号的电压或电流以确定信号时间常数。 然后将信号时间常数与模型时间常数结合使用以确定何时达到峰值振幅。 当达到峰值振幅时，波形中断。 还提供了通过测量注入电极的阻抗然后选择具有提供等于模型时间常数的RC时间常数的电容器的除颤器来选择心脏除颤器的方法。
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公开(公告)号：US20120143286A1
公开(公告)日：2012-06-07
申请号：US13306745
申请日：2011-11-29
IPC分类号： A61N1/372
CPC分类号： A61N1/37282 , A61N1/0556 , A61N1/36132 , A61N1/3615 , A61N1/36178 , A61N1/36185 , A61N1/37252
摘要： According to an embodiment of a method performed by an implantable medical device to deliver a neural stimulation therapy to a patient, a lower dose of the neural stimulation therapy is delivered to the patient. The dose of the neural stimulation therapy is automatically increased from the lower dose to a higher dose, and the higher dose of the neural stimulation therapy is delivered to the patient. A trigger that is controlled by the patient is detected, and the dose of the neural stimulation therapy is automatically returned from the higher dose back to the lower dose in response to detecting the trigger.
摘要翻译： 根据由可植入医疗装置执行以向患者递送神经刺激疗法的方法的实施例，将较低剂量的神经刺激疗法递送给患者。 神经刺激治疗的剂量自动从较低剂量增加到较高剂量，而较高剂量的神经刺激疗法则传递给患者。 检测由患者控制的触发器，并且响应于检测到触发，神经刺激治疗的剂量自动从较高剂量返回到较低剂量。
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7.发明授权
公开(公告)号：US5468254A
公开(公告)日：1995-11-21
申请号：US97463
申请日：1993-07-26
申请人： Stephen J. Hahn , David K. Swanson
发明人： Stephen J. Hahn , David K. Swanson
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906
摘要： A method and apparatus for converting an arrhythmia of a heart using a biphasic truncated exponential waveform wherein the first phase is of shorter duration than the second phase.
摘要翻译： 一种使用双相截短指数波形转换心脏心律失常的方法和装置，其中第一阶段的持续时间比第二阶段短。
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公开(公告)号：US5230337A
公开(公告)日：1993-07-27
申请号：US912950
申请日：1992-07-14
IPC分类号： A61N1/05
CPC分类号： A61N1/05
摘要： Implantable electrodes for defibrillation are formed of pluralities of electrode segments. Each of the segments is relatively long and narrow. The electrode segments can be parallel and spaced apart from one another a distance at least ten times the nominal width, with one end of each segment mounted to a transverse distal portion of an electrically conductive lead coupling the electrode to a defibrillation pulse generator. Alternatively, segments can branch or radiate outwardly from a common junction. In yet another arrangement, electrode segments are portions of a single conductive path at the distal end of a lead from a pulse generator, arranged in either a spiral configuration or a serpentine configuration which can align electrode segments side by side, parallel and spaced apart. The electrode segments can be formed of composite conductors in the form of titanium ribbons or wires with a sputtered outer layer of platinum, or a silver core in a stainless steel tube, with a platinum layer formed onto the tube. The electrodes are highly compliant yet can provide large effective areas for defibrillation, enabling a transthoracic pulsing arrangement of two electrodes on opposite sides of the heart, implanted subcutaneously outside of the thoracic region.
摘要翻译： 用于除颤的可植入电极由多个电极段形成。 每个段都相对长而窄。 电极段可以彼此平行和间隔至少十倍于标称宽度的距离，每个段的一端安装到将电极耦合到除颤脉冲发生器的导电引线的横向远端部分。 或者，片段可以从公共接头向外分支或辐射。 在另一种布置中，电极段是在来自脉冲发生器的引线的远端处的单个导电路径的部分，其布置成螺旋构造或蛇形结构，其可以并排并排隔离电极段。 电极段可以由具有溅射的铂外层或不锈钢管中的银芯的钛带或电线形式的复合导体形成，铂层形成在管上。 电极是高度依从性的，但可以为除颤提供大的有效区域，使得能够在心脏外侧皮下植入心脏两侧的两个电极的经胸部脉冲排列。
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公开(公告)号：US20130053926A1
公开(公告)日：2013-02-28
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译： 一些实施例提供用于递送神经刺激的系统。 一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及 诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。
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10.发明申请METHOD AND APPARATUS FOR ADAPTIVE CONTROL OF NEUROSTIMULATION USING CARDIAC RESTITUTION 有权使用心脏衰竭治疗神经病学自适应控制的方法和装置公开(公告)号：US20130053914A1
公开(公告)日：2013-02-28
申请号：US13586503
申请日：2012-08-15
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/36139
摘要： A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.
摘要翻译： 神经刺激系统以各种心脏间隔测量心脏参数并分析其恢复，包括计算相对于心脏间隔变化的恢复参数的变化率的恢复斜率。 在各种实施例中，系统使用恢复斜率来提供神经刺激的自适应控制。 在各种实施例中，测量并分析一个或多个心脏参数，例如动作电位持续时间（APD），传导速度（CV），QT间期（QT）和/或T波形态（TM）参数，以分析每个参数的恢复 ，然后用于控制神经刺激的递送。
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