公开(公告)号：US09801548B2

公开(公告)日：2017-10-31

申请号：US13959240

申请日：2013-08-05

Applicant: Bruker Biospin Corporation

Inventor： Gilbert Feke ,  Laurie L. Voci

IPC: A61B5/00 ,  G01N21/64 ,  G01N21/17

CPC classification number: A61B5/0071 ,  A61B5/0077 ,  A61B2576/00 ,  G01N21/6456 ,  G01N2021/1782 ,  G01N2021/1787 ,  G01N2201/0635

Abstract: Apparatus and method for performing depth sectioned fluorescence imaging of a turbid sample including a fluorescent turbid medium, uses an apparatus for quantitative modulated fluorescence imaging, the apparatus including projection optics with a first optical axis, to expose the turbid sample to a periodic pattern of excitation radiation to provide depth-resolved discrimination of fluorescent structures within the turbid medium; an image capture module, including a second optical axis and a detection beam path, to receive a data image from the sample; and a signal processor to transform the data image from the sample, spatially filter the transformed data image from the sample, and reconstruct the filtered, transformed data image from the sample.

公开(公告)号：US20160183891A1

公开(公告)日：2016-06-30

申请号：US14833918

申请日：2015-08-24

Applicant: Bruker Biospin Corporation

Inventor： Gilbert Feke ,  William E. McLaughlin ,  Douglas L. Vizard

IPC: A61B6/00 ,  A61B5/00

CPC classification number: A61B6/4417 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0071 ,  A61B6/00 ,  A61B6/5247 ,  A61B2562/17

Abstract: An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.

Abstract translation: 一种用于对固定物体进行成像的成像系统和方法。 成像系统包括适于在固定状态下接收物体的支撑构件。 该系统还包括用于在各种成像模式下成像固定的物体以捕获物体的图像的装置。 成像系统还包括可移动荧光屏。 荧光屏适于可移动而不移动固定的物体和支撑构件。

公开(公告)号：US20150105656A1

公开(公告)日：2015-04-16

申请号：US14188175

申请日：2014-02-24

Applicant: Bruker Biospin Corporation

Inventor： Gilbert Feke ,  Benjamin F. Geldhof ,  Warren M. Leevy ,  Mark E. Bridges ,  William E. McLaughlin ,  Rao Papineni

IPC: A61B6/00 ,  A61B5/00 ,  A61M5/00 ,  A61D7/04

CPC classification number: A61B6/508 ,  A61B5/0059 ,  A61B5/0082 ,  A61B5/6887 ,  A61B6/00 ,  A61B6/04 ,  A61B6/4417 ,  A61B2503/40 ,  A61D7/04 ,  A61M5/007

Abstract: A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.

Abstract translation: 公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。 动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。 公开了使用扭转支撑技术的成像方法。

公开(公告)号：US20140088438A1

公开(公告)日：2014-03-27

申请号：US13959240

申请日：2013-08-05

Applicant: Bruker Biospin Corporation

Inventor： Gilbert Feke ,  Laurie L. Voci

IPC: A61B5/00

CPC classification number: A61B5/0071 ,  A61B5/0077 ,  A61B2576/00 ,  G01N21/6456 ,  G01N2021/1782 ,  G01N2021/1787 ,  G01N2201/0635

Abstract: An imaging system for imaging an object. More specifically, an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source wherein the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected to minimize excitation radiation from reaching the detection beam path.

Abstract translation: 用于成像对象的成像系统。 更具体地说，一种能够在诸如人或动物组织的混浊介质中进行深度分割荧光成像的成像系统基本上最小化到达检测光束路径的激发辐射。 成像系统包括激发辐射源的布置，其中源的光轴相对于照相机的光轴倾斜，源的光学平面和物体的光学平面经受Scheimpflug条件，并且 选择源的倾斜角度使得入射到物体上的激发辐射被反射以使得到达检测光束路径的激发辐射最小化。