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    Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives
    1.
    发明申请
    Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives 失效
    神经酰胺衍生物，其制备方法以及治疗特应性皮炎的治疗剂，其包含所述神经酰胺衍生物

    公开(公告)号：US20080161272A1

    公开(公告)日：2008-07-03

    申请号：US12005226

    申请日：2007-12-26

    申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

    发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

    IPC分类号： A61K31/661 ,  C07F9/09 ,  A61P17/00

    CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

    摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

    摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中R 1和R 2， 各自独立地为具有4至22个碳原子的直链或支链烷基。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

    Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives
    2.
    发明授权
    Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives 失效
    神经酰胺衍生物，其制备方法以及治疗特应性皮炎的治疗剂，其包含所述神经酰胺衍生物

    公开(公告)号：US07462739B2

    公开(公告)日：2008-12-09

    申请号：US12005226

    申请日：2007-12-26

    申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

    发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

    IPC分类号： C07F9/22 ,  C07F9/28

    CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

    摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

    摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和用于治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中，R 1和R 2各自独立地为具有 4至22个碳原子。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。