公开(公告)号：US20080161272A1

公开(公告)日：2008-07-03

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： A61K31/661 ,  C07F9/09 ,  A61P17/00

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中R 1和R 2， 各自独立地为具有4至22个碳原子的直链或支链烷基。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US07462739B2

公开(公告)日：2008-12-09

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： C07F9/22 ,  C07F9/28

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和用于治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中，R 1和R 2各自独立地为具有 4至22个碳原子。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US20060094790A1

公开(公告)日：2006-05-04

申请号：US11260745

申请日：2005-10-27

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jong Kwon ,  Yong-Moon Lee ,  Yoo-Hun Kim ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Chang-Woo Lee ,  Myong-Lyoll Lee

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jong Kwon ,  Yong-Moon Lee ,  Yoo-Hun Kim ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Chang-Woo Lee ,  Myong-Lyoll Lee

IPC分类号： A61K31/16

CPC分类号： A61K31/16 ,  A61K8/68 ,  A61Q19/08 ,  C07C235/08 ,  C07C235/74

摘要： Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.

摘要翻译： 公开了对鞘氨醇激酶活化剂有效的非天然神经酰胺化合物，因此可用于皮肤疾病治疗剂。 鞘氨醇激酶激活剂增强了鞘氨醇-1-磷酸的产生，以显示由鞘氨醇-1-磷酸提供的各种生理活性。 生理活动包括：控制角质形成细胞的增殖和分化，成纤维细胞的增殖和胶原合成，导致伤口的治疗，恢复特应性皮炎和牛皮癣损伤的皮肤功能; 抑制由紫外线引起的皱纹和皮肤刺激，随后改善皱纹和抑制皮肤老化; 并减少皮肤萎缩，这是局部应用类固醇的典型副作用。 因此，鞘氨醇激酶激活剂可用于皮肤疾病治疗剂，用于治疗由局部应用类固醇的副作用引起的皮肤伤口，皱纹，特应性皮炎，湿疹，牛皮癣或皮肤萎缩。

公开(公告)号：US20080020947A1

公开(公告)日：2008-01-24

申请号：US11544900

申请日：2006-10-06

申请人： Byeong-Deog Park ,  Myung-Jin Lee ,  Mi-Jong Kwon ,  Hyung-Sub Gwak ,  Myung-Kyum Kim ,  Yoon Kim

发明人： Byeong-Deog Park ,  Myung-Jin Lee ,  Mi-Jong Kwon ,  Hyung-Sub Gwak ,  Myung-Kyum Kim ,  Yoon Kim

IPC分类号： G06K9/00 ,  C09K8/14 ,  C09K8/05 ,  C04B33/04

CPC分类号： B09C1/10 ,  B01J23/44 ,  C12N1/26 ,  C12R1/01

摘要： Disclosed herein are novel microorganisms having excellent biodegradability and a method for the bioremediation of oil-contaminated soil. The novel microorganisms are specified as Rhodococcus baikoneurensis EN3 KCTC19082, Acinetobacter johnsonii EN67 KCTC12360 and Acinetobacter haemolyticus EN96 KCTC12361. In the bioremediation method, in addition to said novel microorganisms, various microorganisms of Nocardia sp., Gordonia sp., Rhodococcus sp. and Acinetobactor sp. can be used, and the oil biodegradation activities of these microbial strains can be increased by adding biosurfactant 2-alkyl-3-hydroxylic acid or its derivative. According to the disclosed invention, oil-contaminated soils can be purified in an effective, economical and eco-friendly manner compared to prior bioremediation methods.

摘要翻译： 本文公开了具有优异生物降解性的新型微生物和用于污染土壤的生物修复的方法。 这些新型微生物被指定为红球菌（Bucoconeurensis）EN3KCTC19082，不动杆菌属不动杆菌EN67 KCTC12360和溶血性不动杆菌属EN96 KCTC12361。 在生物修复方法中，除了所述新型微生物之外，还存在诺卡氏菌属（Nocardia sp。），戈多尼氏菌（Gordonia sp。），红球菌属（Rhodococcus sp。）， 和Acinetobactor sp。 可以通过添加生物表面活性剂2-烷基-3-羟基酸或其衍生物来提高这些微生物菌株的油的生物降解活性。 根据所公开的发明，与以前的生物修复方法相比，可以以有效，经济和环保的方式净化油污染的土壤。

公开(公告)号：US20100173995A1

公开(公告)日：2010-07-08

申请号：US12319324

申请日：2009-01-06

申请人： Byeong-Deog Park ,  Hyung-Sub Gwak ,  Se-Kyoo Jeong ,  Jong-Hwan Bae

发明人： Byeong-Deog Park ,  Hyung-Sub Gwak ,  Se-Kyoo Jeong ,  Jong-Hwan Bae

IPC分类号： A61K31/164 ,  C07C233/31 ,  A61P17/10

CPC分类号： A61K31/164

摘要： Disclosed herein is the use of a non-natural compound represented by the following formula 1 as an activator of the peroxisome proliferator activated receptor-α (PPAR-α) which shows an anti-inflammatory effect on inflammatory skin diseases. The PPAR-α activator increases the expression of PPAR-α in the skin to enhance various physiological effects of PPAR-α, that is, the anti-inflammatory effect caused by inhibiting the activity of transcription factors such as the nuclear factor κK (NF-κK) that induces inflammatory reactions, the effect of improving the epidermal permeability barrier function of the skin, and the effect of promoting the terminal differentiation of epidermal keratinocytes. Thus, the PPAR-α activator is useful for the treatment, alleviation or amelioration of skin diseases such as acne, seborrheic dermatitis, viral skin diseases, urticaria, pruritus, viral infectious diseases and contact dermatitis. wherein R1 and R2 are the same or different and each represents a linear or branched C1-22 alkyl group, a phenyl group or a benzene group.

摘要翻译： 本文公开了使用由下式1表示的非天然化合物作为对炎性皮肤疾病具有抗炎作用的过氧化物酶体增殖物激活受体α（PPAR-α）的活化剂。 PPAR-α活化剂增加PPAR-α在皮肤中的表达，以增强PPAR-α的各种生理作用，即通过抑制转录因子如核因子和kgr（K）的活性而引起的抗炎作用 NF-和kgr; K），其诱导炎症反应，改善皮肤表皮渗透屏障功能的作用，以及促进表皮角化细胞末端分化的作用。 因此，PPAR-α活化剂可用于治疗，缓解或改善皮肤疾病如痤疮，脂溢性皮炎，病毒性皮肤病，荨麻疹，瘙痒症，病毒感染性疾病和接触性皮炎。 其中R1和R2相同或不同，并且各自表示直链或支链C 1-22烷基，苯基或苯基。

公开(公告)号：US20070286835A1

公开(公告)日：2007-12-13

申请号：US11495100

申请日：2006-07-28

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Shin-Hee Lee

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Shin-Hee Lee

IPC分类号： A61K31/36 ,  A61K8/42 ,  A61K8/36

CPC分类号： A61Q19/00 ,  A61K8/042 ,  A61K8/361 ,  A61K8/37 ,  A61K8/63 ,  A61K8/68 ,  A61K31/36 ,  A61K2800/75 ,  A61Q17/00

摘要： Disclosed is a skin external preparation containing stratum corneum intercellular lipids, ceramide, and having a hexagonal gel structure. More particularly, the skin external preparation having the hexagonal gel structure contains, as stratum corneum intercellular lipid components, ceramide and cholesterol or its derivative and/or fatty acid, and as an emulsifying agent, sorbitan stearate, sucrose cocoate or a mixture thereof. The hexagonal gel structure of the external preparation is in the same form as a lamellar structure formed by stratum corneum intercellular lipids on the actual skin, and this lamellar structure plays a very important role in skin protection and moisturizing functions, and thus provides very useful effects for skin showing a damaged skin barrier function in various skin diseases or various skin types.

摘要翻译： 公开了含有角质细胞间质脂质，神经酰胺，并具有六角形凝胶结构的皮肤外用制剂。 更具体地说，具有六角形凝胶结构的皮肤外用制剂含有作为角质细胞间质的脂质组分，神经酰胺和胆固醇或其衍生物和/或脂肪酸，以及作为乳化剂，脱水山梨糖醇硬脂酸酯，蔗糖可可酯或其混合物。 外用制剂的六角形凝胶结构与实际皮肤上的角质层细胞间脂质形成的层状结构相同，这种层状结构在皮肤保护和保湿功能中起着非常重要的作用，因此提供非常有用的效果 用于在各种皮肤疾病或各种皮肤类型中显示受损的皮肤屏障功能的皮肤。