公开(公告)号：US20130165652A1

公开(公告)日：2013-06-27

申请号：US13818420

申请日：2011-08-25

申请人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

发明人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC分类号： C07D471/04

CPC分类号： C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

摘要： The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.

摘要翻译： 根据本发明的杂环化合物可以治疗和预防炎性疾病并愈合皮肤伤口，特别是具有恢复受损的皮肤屏障，减少炎性皮肤疾病中的炎症和瘙痒的作用。 此外，含有本发明化合物作为活性成分的组合物可以用于缓和各种炎性疾病和PAR-2过度表达的疾病，特别是该组合物可抑制PAR-2在皮肤中的活性 ，使得该组合物可以用作具有抗炎功能的组合物，所述炎性皮肤病包括特应性皮炎等。

公开(公告)号：US20130158047A1

公开(公告)日：2013-06-20

申请号：US13818355

申请日：2011-08-25

申请人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

发明人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC分类号： C07D235/08

CPC分类号： C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

摘要： Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

摘要翻译： 提供具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是显示恢复破坏的皮肤屏障，减轻炎症和瘙痒的作用。 此外，含有该化合物作为有效成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2） - 去表达疾病，并且可特别用作具有炎性功能的组合物 皮肤病，包括特应性皮炎等，通过抑制PAR-2活性。

公开(公告)号：US20080161272A1

公开(公告)日：2008-07-03

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： A61K31/661 ,  C07F9/09 ,  A61P17/00

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中R 1和R 2， 各自独立地为具有4至22个碳原子的直链或支链烷基。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US08809541B2

公开(公告)日：2014-08-19

申请号：US13818355

申请日：2011-08-25

申请人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

发明人： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC分类号： A61K31/497 ,  C07D211/32 ,  A61Q19/00 ,  A61K8/49 ,  C07D471/04 ,  C07D235/08

CPC分类号： C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

摘要： Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

摘要翻译： 提供具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是显示恢复破坏的皮肤屏障，减轻炎症和瘙痒的作用。 此外，含有该化合物作为有效成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2） - 去表达疾病，并且可特别用作具有炎性功能的组合物 皮肤病，包括特应性皮炎等，通过抑制PAR-2活性。

公开(公告)号：US07462739B2

公开(公告)日：2008-12-09

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： C07F9/22 ,  C07F9/28

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和用于治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中，R 1和R 2各自独立地为具有 4至22个碳原子。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US20070286835A1

公开(公告)日：2007-12-13

申请号：US11495100

申请日：2006-07-28

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Shin-Hee Lee

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Shin-Hee Lee

IPC分类号： A61K31/36 ,  A61K8/42 ,  A61K8/36

CPC分类号： A61Q19/00 ,  A61K8/042 ,  A61K8/361 ,  A61K8/37 ,  A61K8/63 ,  A61K8/68 ,  A61K31/36 ,  A61K2800/75 ,  A61Q17/00

摘要： Disclosed is a skin external preparation containing stratum corneum intercellular lipids, ceramide, and having a hexagonal gel structure. More particularly, the skin external preparation having the hexagonal gel structure contains, as stratum corneum intercellular lipid components, ceramide and cholesterol or its derivative and/or fatty acid, and as an emulsifying agent, sorbitan stearate, sucrose cocoate or a mixture thereof. The hexagonal gel structure of the external preparation is in the same form as a lamellar structure formed by stratum corneum intercellular lipids on the actual skin, and this lamellar structure plays a very important role in skin protection and moisturizing functions, and thus provides very useful effects for skin showing a damaged skin barrier function in various skin diseases or various skin types.

摘要翻译： 公开了含有角质细胞间质脂质，神经酰胺，并具有六角形凝胶结构的皮肤外用制剂。 更具体地说，具有六角形凝胶结构的皮肤外用制剂含有作为角质细胞间质的脂质组分，神经酰胺和胆固醇或其衍生物和/或脂肪酸，以及作为乳化剂，脱水山梨糖醇硬脂酸酯，蔗糖可可酯或其混合物。 外用制剂的六角形凝胶结构与实际皮肤上的角质层细胞间脂质形成的层状结构相同，这种层状结构在皮肤保护和保湿功能中起着非常重要的作用，因此提供非常有用的效果 用于在各种皮肤疾病或各种皮肤类型中显示受损的皮肤屏障功能的皮肤。

公开(公告)号：US20060094790A1

公开(公告)日：2006-05-04

申请号：US11260745

申请日：2005-10-27

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jong Kwon ,  Yong-Moon Lee ,  Yoo-Hun Kim ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Chang-Woo Lee ,  Myong-Lyoll Lee

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jong Kwon ,  Yong-Moon Lee ,  Yoo-Hun Kim ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Chang-Woo Lee ,  Myong-Lyoll Lee

IPC分类号： A61K31/16

CPC分类号： A61K31/16 ,  A61K8/68 ,  A61Q19/08 ,  C07C235/08 ,  C07C235/74

摘要： Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.

摘要翻译： 公开了对鞘氨醇激酶活化剂有效的非天然神经酰胺化合物，因此可用于皮肤疾病治疗剂。 鞘氨醇激酶激活剂增强了鞘氨醇-1-磷酸的产生，以显示由鞘氨醇-1-磷酸提供的各种生理活性。 生理活动包括：控制角质形成细胞的增殖和分化，成纤维细胞的增殖和胶原合成，导致伤口的治疗，恢复特应性皮炎和牛皮癣损伤的皮肤功能; 抑制由紫外线引起的皱纹和皮肤刺激，随后改善皱纹和抑制皮肤老化; 并减少皮肤萎缩，这是局部应用类固醇的典型副作用。 因此，鞘氨醇激酶激活剂可用于皮肤疾病治疗剂，用于治疗由局部应用类固醇的副作用引起的皮肤伤口，皱纹，特应性皮炎，湿疹，牛皮癣或皮肤萎缩。

公开(公告)号：US20100173995A1

公开(公告)日：2010-07-08

申请号：US12319324

申请日：2009-01-06

申请人： Byeong-Deog Park ,  Hyung-Sub Gwak ,  Se-Kyoo Jeong ,  Jong-Hwan Bae

发明人： Byeong-Deog Park ,  Hyung-Sub Gwak ,  Se-Kyoo Jeong ,  Jong-Hwan Bae

IPC分类号： A61K31/164 ,  C07C233/31 ,  A61P17/10

CPC分类号： A61K31/164

摘要： Disclosed herein is the use of a non-natural compound represented by the following formula 1 as an activator of the peroxisome proliferator activated receptor-α (PPAR-α) which shows an anti-inflammatory effect on inflammatory skin diseases. The PPAR-α activator increases the expression of PPAR-α in the skin to enhance various physiological effects of PPAR-α, that is, the anti-inflammatory effect caused by inhibiting the activity of transcription factors such as the nuclear factor κK (NF-κK) that induces inflammatory reactions, the effect of improving the epidermal permeability barrier function of the skin, and the effect of promoting the terminal differentiation of epidermal keratinocytes. Thus, the PPAR-α activator is useful for the treatment, alleviation or amelioration of skin diseases such as acne, seborrheic dermatitis, viral skin diseases, urticaria, pruritus, viral infectious diseases and contact dermatitis. wherein R1 and R2 are the same or different and each represents a linear or branched C1-22 alkyl group, a phenyl group or a benzene group.

摘要翻译： 本文公开了使用由下式1表示的非天然化合物作为对炎性皮肤疾病具有抗炎作用的过氧化物酶体增殖物激活受体α（PPAR-α）的活化剂。 PPAR-α活化剂增加PPAR-α在皮肤中的表达，以增强PPAR-α的各种生理作用，即通过抑制转录因子如核因子和kgr（K）的活性而引起的抗炎作用 NF-和kgr; K），其诱导炎症反应，改善皮肤表皮渗透屏障功能的作用，以及促进表皮角化细胞末端分化的作用。 因此，PPAR-α活化剂可用于治疗，缓解或改善皮肤疾病如痤疮，脂溢性皮炎，病毒性皮肤病，荨麻疹，瘙痒症，病毒感染性疾病和接触性皮炎。 其中R1和R2相同或不同，并且各自表示直链或支链C 1-22烷基，苯基或苯基。

公开(公告)号：US20080020947A1

公开(公告)日：2008-01-24

申请号：US11544900

申请日：2006-10-06

申请人： Byeong-Deog Park ,  Myung-Jin Lee ,  Mi-Jong Kwon ,  Hyung-Sub Gwak ,  Myung-Kyum Kim ,  Yoon Kim

发明人： Byeong-Deog Park ,  Myung-Jin Lee ,  Mi-Jong Kwon ,  Hyung-Sub Gwak ,  Myung-Kyum Kim ,  Yoon Kim

IPC分类号： G06K9/00 ,  C09K8/14 ,  C09K8/05 ,  C04B33/04

CPC分类号： B09C1/10 ,  B01J23/44 ,  C12N1/26 ,  C12R1/01

摘要： Disclosed herein are novel microorganisms having excellent biodegradability and a method for the bioremediation of oil-contaminated soil. The novel microorganisms are specified as Rhodococcus baikoneurensis EN3 KCTC19082, Acinetobacter johnsonii EN67 KCTC12360 and Acinetobacter haemolyticus EN96 KCTC12361. In the bioremediation method, in addition to said novel microorganisms, various microorganisms of Nocardia sp., Gordonia sp., Rhodococcus sp. and Acinetobactor sp. can be used, and the oil biodegradation activities of these microbial strains can be increased by adding biosurfactant 2-alkyl-3-hydroxylic acid or its derivative. According to the disclosed invention, oil-contaminated soils can be purified in an effective, economical and eco-friendly manner compared to prior bioremediation methods.

摘要翻译： 本文公开了具有优异生物降解性的新型微生物和用于污染土壤的生物修复的方法。 这些新型微生物被指定为红球菌（Bucoconeurensis）EN3KCTC19082，不动杆菌属不动杆菌EN67 KCTC12360和溶血性不动杆菌属EN96 KCTC12361。 在生物修复方法中，除了所述新型微生物之外，还存在诺卡氏菌属（Nocardia sp。），戈多尼氏菌（Gordonia sp。），红球菌属（Rhodococcus sp。）， 和Acinetobactor sp。 可以通过添加生物表面活性剂2-烷基-3-羟基酸或其衍生物来提高这些微生物菌株的油的生物降解活性。 根据所公开的发明，与以前的生物修复方法相比，可以以有效，经济和环保的方式净化油污染的土壤。

公开(公告)号：US06221371B1

公开(公告)日：2001-04-24

申请号：US09308031

申请日：1999-05-10

申请人： In-sub Baik ,  Jong-gi Lee ,  Byeong-deog Park ,  Yoon Kim ,  Myung-jin Lee

发明人： In-sub Baik ,  Jong-gi Lee ,  Byeong-deog Park ,  Yoon Kim ,  Myung-jin Lee

IPC分类号： A61K600

CPC分类号： A61Q19/00 ,  A61K8/68 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q19/08 ,  C07C235/08 ,  C07C235/74 ,  C07H15/12

摘要： The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): R1—COCHR2CONR3R4  (I) R1—CH(OH)CHR2CONR3R4  (II) wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6˜22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2˜C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.

摘要翻译： 本发明涉及由式（I）或（II）表示的假花生酰胺衍生物：其中，R1和R2各自表示具有6〜22个碳原子的直链或支链烷基或烯基; R 3和R 4各自表示氢，甲基，乙基，丙基或具有一个或多个羟基或单糖的直链或支链C 2 -C 6烷基，其制备方法和含有该羟基的皮肤外用制剂 。 当根据本发明的假心外酰胺衍生物应用于皮肤外用制剂时，皮肤和毛发的保湿性和弹性得到增强，使得衍生物可用于保护皮肤老化。 此外，该衍生物可用于诱导损伤皮肤上形成脂质层并防止脂质合成的抑制。