公开(公告)号：US20080161272A1

公开(公告)日：2008-07-03

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： A61K31/661 ,  C07F9/09 ,  A61P17/00

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中R 1和R 2， 各自独立地为具有4至22个碳原子的直链或支链烷基。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US07462739B2

公开(公告)日：2008-12-09

申请号：US12005226

申请日：2007-12-26

申请人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

发明人： Byeong-Deog Park ,  Jong-Kyung Youm ,  Hyung-Sub Gwak ,  Mi-Jung Kwon ,  Hwan-Mook Kim ,  Jong-Soon Kang ,  Sang-Bae Han

IPC分类号： C07F9/22 ,  C07F9/28

CPC分类号： A61K8/68 ,  A61Q19/00 ,  C07F9/091

摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: wherein, R1 and R2 are each independently straight or branched alkyl groups having 4 to 22 carbon atoms. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by suppressing or improving inflammatory conditions in the atopic dermatitis in addition to giving immunoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.

摘要翻译： 公开了由下式1或2表示的神经酰胺衍生物，其制备方法和用于治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为活性成分：其中，R 1和R 2各自独立地为具有 4至22个碳原子。 用于治疗特应性皮炎的治疗剂，包括根据本发明的神经酰胺衍生物作为活性成分，可用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤病，抑制或改善炎性病症 在特应性皮炎中除了给予免疫调节功能外，还抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

公开(公告)号：US20120196831A1

公开(公告)日：2012-08-02

申请号：US13500843

申请日：2010-10-08

申请人： Gyoon-Hee Han ,  Yong Seok Choi ,  Sang-Bae Han ,  Jong-Ho Lee ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Chang-Woo Lee

发明人： Gyoon-Hee Han ,  Yong Seok Choi ,  Sang-Bae Han ,  Jong-Ho Lee ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Chang-Woo Lee

IPC分类号： A61K31/724 ,  A61P3/04 ,  A61P9/12 ,  A61P3/10 ,  A61P9/10 ,  A61P9/00 ,  A61P25/00 ,  C08B37/16 ,  A61P3/06

CPC分类号： A61K31/724 ,  A23L29/35 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2200/332 ,  A23V2250/5112

摘要： There is provided a composition for preventing and treating obesity including high water-soluble β-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble β-cyclodextrin derivatives, especially, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.

摘要翻译： 提供了用于预防和治疗包括高水溶性和环糊精衍生物作为有效成分的肥胖的组合物。 具体地说，包含高水溶性β-环糊精衍生物，特别是2-羟丙基 - 环糊精（HP-＆bgr-CD，HPBCD）的组合物具有抑制高脂肪引起的体重增加的作用 饮食，通过减少饮食摄入量，减少身体脂肪，减少肝脏重量并显着降低通过在空腹进食葡萄糖和麦芽糖而引起的血糖的急剧增加，从而抑制食欲，从而可用于预防和治疗肥胖 预防和治疗肥胖引起的各种疾病，抑制晚饭后血糖急剧增加。

公开(公告)号：US20090048328A1

公开(公告)日：2009-02-19

申请号：US11988561

申请日：2006-07-10

申请人： Hwan Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee ,  Ki-Hoon Lee ,  Sung-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Won-Kee Yoon ,  Young-Kook Kim

发明人： Hwan Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee ,  Ki-Hoon Lee ,  Sung-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Won-Kee Yoon ,  Young-Kook Kim

IPC分类号： A61K31/4155 ,  A61P37/06

CPC分类号： C12P17/10

摘要： This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B-1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosup-pressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.

摘要翻译： 本发明涉及用于预防和治疗急性移植物抗宿主病的组合物，其包括从沙雷氏菌属B-1231 KCTC 0386BP分离的天竺葵素作为有效成分。 通过抑制T细胞活化所需的IL-2受体的表达，通过选择性抑制T细胞的增殖，产生免疫抑制作用。 由于两种物质具有不同的作用模式，因此可以单独使用或与环孢菌素A联合使用。 这些使癌细胞生成素有效预防和治疗急性移植物抗宿主病。

公开(公告)号：US08975241B2

公开(公告)日：2015-03-10

申请号：US13500843

申请日：2010-10-08

申请人： Gyoon-Hee Han ,  Yong Seok Choi ,  Sang-Bae Han ,  Jong-Ho Lee ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Chang-Woo Lee

发明人： Gyoon-Hee Han ,  Yong Seok Choi ,  Sang-Bae Han ,  Jong-Ho Lee ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Chang-Woo Lee

IPC分类号： A61K31/724 ,  A23L1/09 ,  A23L1/30

CPC分类号： A61K31/724 ,  A23L29/35 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2200/332 ,  A23V2250/5112

摘要： There is provided a composition for preventing and treating obesity including high water-soluble β-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble β-cyclodextrin derivatives, especially, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.

摘要翻译： 提供了用于预防和治疗包括高水溶性和环糊精衍生物作为有效成分的肥胖的组合物。 具体地说，包含高水溶性β-环糊精衍生物，特别是2-羟丙基 - 环糊精（HP-＆bgr-CD，HPBCD）的组合物具有抑制高脂肪引起的体重增加的作用 饮食，通过减少饮食摄入量，减少身体脂肪，减少肝脏重量并显着降低通过在空腹进食葡萄糖和麦芽糖而引起的血糖的急剧增加，从而抑制食欲，从而可用于预防和治疗肥胖 预防和治疗肥胖引起的各种疾病，抑制晚饭后血糖急剧增加。

公开(公告)号：US20090087444A1

公开(公告)日：2009-04-02

申请号：US12298903

申请日：2006-09-29

申请人： Hwan-Mook Kim ,  Sang-Bae Han ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Jee-Youn Kim ,  Chang-Woo Lee

发明人： Hwan-Mook Kim ,  Sang-Bae Han ,  Song-Kyu Park ,  Ki-Ho Lee ,  Jong-Soon Kang ,  Ki-Hoon Lee ,  Jee-Youn Kim ,  Chang-Woo Lee

IPC分类号： A61K39/00

CPC分类号： A61K31/715

摘要： The present invention relates to a pharmaceutical composition for activating dendritic cells having polysaccharides from Angelica gigas Nakai as valid component. The angelan, polysaccharides separated from Angelica gigas Nakai, can improve the revelation of surface molecule of dendritic cells, the secret of cytokine of dendritic cells, the proliferation capability of T cells of dendritic cells, and the generation of cytokine such as IL-2.

摘要翻译： 本发明涉及一种用于激活具有来自当归奈加的多糖的树突状细胞作为有效成分的药物组合物。 从当归纳西分离的天竺鼠多糖可以改善树突状细胞表面分子的揭示，树突状细胞的细胞因子的分泌，树突状细胞的T细胞的增殖能力和细胞因子如IL-2的产生。

公开(公告)号：US06943007B2

公开(公告)日：2005-09-13

申请号：US09846634

申请日：2001-05-01

申请人： Ick-Dong Yoo ,  Soo-Muk Cho ,  Byeung-Wook Park ,  Jae-Kuk Yoo ,  Nam-Doo Hong ,  Hwan-Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee

发明人： Ick-Dong Yoo ,  Soo-Muk Cho ,  Byeung-Wook Park ,  Jae-Kuk Yoo ,  Nam-Doo Hong ,  Hwan-Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee

IPC分类号： A01H15/00 ,  A61K31/00 ,  C12N1/14 ,  A01N63/04 ,  C12P1/02 ,  C12P19/04

CPC分类号： A01H15/00 ,  Y10S435/911

摘要： There is disclosed novel Phellinus linteus Yoo. This mushroom is identified as novel as analyzed by restriction fragment length polymorphism and by microbiological features. A polysaccharide substance isolated from the fruiting bodies or mycelia the strain and other Phellinus spp. has an anticancer activity by inciting the cytotoxicity of T-cells and the antibody forming potency of B-cells. Also, the polysaccharide substance shows a potent activity against cancer metastasis. The polysaccharide substance, which can stimulate the immunity of the body, may be effective in the prophylaxis and treatment of immune-related diseases, such as cancers and AIDS, and in the study on the basic mechanism of the diseases.

摘要翻译： 有披露小说的桑黄柚。 这种蘑菇被鉴定为新颖的，通过限制性片段长度多态性和微生物特征分析。 从子实体或菌丝体中分离出的多糖物质菌株和其他桑黄属。 通过诱导T细胞的细胞毒性和B细胞的抗体形成效力具有抗癌活性。 此外，多糖物质显示出对癌症转移的有效活性。 可以刺激身体免疫力的多糖物质可以有效预防和治疗免疫相关疾病如癌症和艾滋病，以及对疾病基本机制的研究。

公开(公告)号：US6030528A

公开(公告)日：2000-02-29

申请号：US102694

申请日：1998-06-22

申请人： Sang-Bae Han

发明人： Sang-Bae Han

IPC分类号： C02F1/74 ,  C02F3/12 ,  C02F3/30 ,  C02F9/00

CPC分类号： C02F3/1263 ,  C02F3/308 ,  Y02W10/15

摘要： A waste water treatment plant for removing nitrogen and phosphorus is provided. The plant is operable by flow path change and intermittent aeration by the combination of at least two sets if intra-clarifier type oxidation ditches, external-clarifier type oxidation ditches or activated sludge processes.

摘要翻译： 提供了一种用于去除氮和磷的废水处理设备。 如果澄清器内的氧化沟，外部澄清剂型氧化沟或活性污泥工艺，则可通过流路变化和间歇曝气操作至少两套组合。