公开(公告)号：US07501096B2

公开(公告)日：2009-03-10

申请号：US10805871

申请日：2004-03-22

申请人： Byung-Kyu Kim ,  Young-Ho Kim ,  Deok-Ho Kim ,  Jong-Oh Park

发明人： Byung-Kyu Kim ,  Young-Ho Kim ,  Deok-Ho Kim ,  Jong-Oh Park

IPC分类号： B01L3/02

CPC分类号： C12M33/04 ,  B01L3/021

摘要： The present invention relates to a smart pipette for bio-cell manipulation which can freely change orientation of a bio-cell subject to the manipulation by using mechanical friction and applying instantaneous impact when penetrating the subject bio-cell while receiving real-time feedback of force/torque information of the bio-cell. Further, the present invention relates to a bio-cell manipulation method and system using a smart pipette, through which a bio-cell may be manipulated upon the application of the force/torque information generated during the cell manipulation to the smart pipette control. According to the present invention, injection position can be recognized precisely and conveniently regardless of the proficiency of the manipulating person. Thus, the bio-cell manipulation may be automated. Further, the smart pipette quantifies force/torque information feed-backed through the sensor unit and compares it with data acquired in advance through experiments on the same bio-cell. Further, through conducting impact driving when necessary, the present invention makes it possible to conduct bio-cell manipulation with minimum physical damage.

摘要翻译： 本发明涉及用于生物细胞操作的智能移液器，其可以通过使用机械摩擦自由地改变受到操纵的生物体的取向，并且在接受实时反馈的力时穿透受试者生物细胞时施加瞬时冲击 /生物细胞的扭矩信息。 此外，本发明涉及使用智能移液器的生物细胞操作方法和系统，通过该智能移液管，可以在将细胞操作期间产生的力/扭矩信息应用于智能移液管控制时操纵生物体。 根据本发明，无论操纵者的熟练程度如何，都可以精确而方便地识别注射位置。 因此，生物细胞操作可以是自动化的。 此外，智能移液器量化通过传感器单元反馈的力/扭矩信息，并将其与通过在相同生物细胞上的实验预先获得的数据进行比较。 此外，通过在必要时进行冲击驱动，本发明能够以最小的物理损伤进行生物细胞操作。

公开(公告)号：US07011970B2

公开(公告)日：2006-03-14

申请号：US10400290

申请日：2003-03-25

申请人： Byung-Kyu Kim ,  Jung-Yul Park ,  Deok-Ho Kim ,  Jong-Oh Park

发明人： Byung-Kyu Kim ,  Jung-Yul Park ,  Deok-Ho Kim ,  Jong-Oh Park

IPC分类号： A01N1/00

CPC分类号： C12M47/04

摘要： This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of cells, controls the rotation-orientation of the extracted cell automatically, and enables the extracted cell to maintain a certain temperature; and a micro manipulation system that obtains vision information and manipulation information about the extracted single cell and the manipulation tool, provides such information to operator, manipulates the extracted single cell by transmitting the rotation-orientation feedback information and the cell manipulation order of the operator to the bio-MEMS, and manipulates the manipulation tool by transmitting the tool manipulation order of the operator to the manipulation tool. The conventional manual and individualized single cell manipulation can be automated and processed collectively by systematically combining the bio-MEMS with the micro manipulation system.

摘要翻译： 这种用于操纵单个电池的新的自动生物处理工厂系统包括：从多个电池传输，分离和提取单个电池进行操作的生物MEMS，自动控制所提取的电池的旋转取向，并且使能 提取的细胞保持一定的温度; 以及微操作系统，其获取关于所提取的单个单元和操纵工具的视觉信息和操作信息，向操作者提供这样的信息，通过将操作者的旋转取向反馈信息和单元操作顺序发送到操作者来操纵提取的单个单元 生物MEMS，并通过将操作者的工具操作顺序传送到操作工具来操纵操纵工具。 传统的手动和个性化单细胞操作可以通过将生物MEMS与微操作系统系统地组合而被集体地自动化和处理。

公开(公告)号：US20090170741A1

公开(公告)日：2009-07-02

申请号：US12087137

申请日：2006-12-19

申请人： Ho-Sung Choi ,  Deok-Ho Kim

发明人： Ho-Sung Choi ,  Deok-Ho Kim

IPC分类号： C11D3/20

CPC分类号： C11D11/0047 ,  C11D3/0073 ,  C11D7/10 ,  C11D7/267 ,  C11D7/3227 ,  C11D7/5022 ,  G03F7/425

摘要： Provided is a composition for removing polymer residue of a photosensitive etching-resistant layer. The composition includes 0.1 to 80% by weight of a corrosion inhibitor shown in Formula 1; 10 to 80% by weight of a pH control agent of which hydrogen ion concentration is in a weak basic range; 0.1 to 2% by weight of ammonium fluoride; and the remaining percentage by weight of water. The composition for removing the polymer residue can effectively remove insoluble residue generated during a semiconductor fabrication process without inflicting damage on an underlying layer and contains environment-friendly components.

摘要翻译： 提供了用于除去感光性耐蚀层的聚合物残渣的组合物。 该组合物包含0.1至80重量％的式1所示的缓蚀剂; 10〜80重量％的氢离子浓度处于弱碱性范围的pH控制剂; 0.1〜2重量％的氟化铵; 和剩余的重量百分比的水。 用于除去聚合物残余物的组合物可以有效地去除半导体制造过程中产生的不溶性残留物，而不会对下层产生损害，并含有环境友好的组分。

公开(公告)号：US07858572B2

公开(公告)日：2010-12-28

申请号：US12087137

申请日：2006-12-19

申请人： Ho-Sung Choi ,  Deok-Ho Kim

发明人： Ho-Sung Choi ,  Deok-Ho Kim

IPC分类号： C11D7/50

CPC分类号： C11D11/0047 ,  C11D3/0073 ,  C11D7/10 ,  C11D7/267 ,  C11D7/3227 ,  C11D7/5022 ,  G03F7/425

摘要： Provided is a composition for removing polymer residue of a photosensitive etching-resistant layer. The composition includes 0.1 to 80% by weight of a corrosion inhibitor shown in Formula 1; 10 to 80% by weight of a pH control agent of which hydrogen ion concentration is in a weak basic range; 0.1 to 2% by weight of ammonium fluoride; and the remaining percentage by weight of water. The composition for removing the polymer residue can effectively remove insoluble residue generated during a semiconductor fabrication process without inflicting damage on an underlying layer and contains environment-friendly components.

摘要翻译： 提供了用于除去感光性耐蚀层的聚合物残渣的组合物。 该组合物包含0.1至80重量％的式1所示的缓蚀剂; 10〜80重量％的氢离子浓度处于弱碱性范围的pH控制剂; 0.1〜2重量％的氟化铵; 和剩余的重量百分比的水。 用于除去聚合物残余物的组合物可以有效地去除半导体制造过程中产生的不溶性残留物，而不会对下层产生损害，并含有环境友好的组分。