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公开(公告)号：US20070054869A1
公开(公告)日：2007-03-08
申请号：US11449446
申请日：2006-06-07
申请人： C. Bennett , Kenneth Dobie , Don Cleveland , Richard Smith
发明人： C. Bennett , Kenneth Dobie , Don Cleveland , Richard Smith
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。
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公开(公告)号：US20070265219A1
公开(公告)日：2007-11-15
申请号：US11691364
申请日：2007-03-26
申请人： C. Bennett , Nicholas Dean , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Nicholas Dean , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/113 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding thyroid hormone receptor interactor 3. Methods of using these compounds for modulation of thyroid hormone receptor interactor 3 expression and for diagnosis and treatment of disease associated with expression of thyroid hormone receptor interactor 3 are provided
摘要翻译： 提供化合物，组合物和方法用于调节甲状腺激素受体相互作用剂3的表达。该组合物包含针对编码甲状腺激素受体相互作用的核酸的寡核苷酸。3.使用这些化合物调节甲状腺激素受体相互作用3表达和 提供了与甲状腺激素受体相互作用3表达相关的疾病的诊断和治疗
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公开(公告)号：US20060293269A1
公开(公告)日：2006-12-28
申请号：US11449207
申请日：2006-06-07
申请人： C. Bennett , Kenneth Dobie
发明人： C. Bennett , Kenneth Dobie
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
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公开(公告)号：US20050153925A1
公开(公告)日：2005-07-14
申请号：US11013608
申请日：2004-12-16
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。 组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。 提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。
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7.发明申请公开(公告)号：US20050153336A1
公开(公告)日：2005-07-14
申请号：US11004127
申请日：2004-12-03
申请人： C. Bennett , Kenneth Dobie
发明人： C. Bennett , Kenneth Dobie
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT2. Methods of using these compounds for modulation of STAT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节STAT2的表达。 组合物包含靶向编码STAT2的核酸的寡核苷酸。 提供了使用这些化合物调节STAT2表达和用于诊断和治疗与STAT2表达相关的疾病和病症的方法。
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公开(公告)号：US20070185044A1
公开(公告)日：2007-08-09
申请号：US10592435
申请日：2005-03-08
申请人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
发明人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/15001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。
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公开(公告)号：US20050227939A1
公开(公告)日：2005-10-13
申请号：US11036095
申请日：2005-01-14
申请人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21034 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节激肽释放酶6的表达。该组合物包含靶向编码激肽释放酶的核酸的寡核苷酸。6.使用这些化合物调节激肽释放酶6表达并用于诊断和治疗与表达相关的疾病的方法 提供激肽释放酶6。
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10.发明申请公开(公告)号：US20050222073A1
公开(公告)日：2005-10-06
申请号：US11071724
申请日：2005-03-02
申请人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甲状腺激素受体相互作用体6的表达。该组合物包含靶向编码甲状腺激素受体相互作用核酸的反义化合物，特别是反义寡核苷酸。6.使用这些化合物调节甲状腺激素的方法 受体相互作用6表达和用于治疗与甲状腺激素受体相互作用者6的表达相关的疾病。
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