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21 条记录 (耗时 0.043 秒)

    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
    8.
    发明授权
    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 有权
    治疗由宿主细胞重建为生物体组织的植入物的胶原结缔组织的方法

    公开(公告)号：US07736845B2

    公开(公告)日：2010-06-15

    申请号：US11345768

    申请日：2006-01-19

    申请人： David T. Cheung

    发明人： David T. Cheung

    IPC分类号： A61F2/04 ,  A61F2/08

    CPC分类号： A01N1/02 ,  A01N1/0226 ,  A61K38/39 ,  A61L27/3604 ,  A61L27/3687

    摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.

    摘要翻译： 本发明涉及一种治疗从供体移出的胶原结缔组织的方法，用于植入到受体中，其被宿主细胞重新吸收或重新定植而没有免疫排斥和炎症反应。 从供体移除后，将组织修整，然后在温度范围为4至10摄氏度的冷稳定溶液中浸泡。 然后将组织在预定温度下浸入预定量和浓度的聚二醇，盐，过氧化氢和磷酸盐缓冲液第一溶液中并具有足够的离子强度，以使研磨物质解离，使得胶原纤维保持稳定。 然后将组织在预定温度下在醇和水溶液中浸泡足够的时间以除去第一溶液的残余物。 除去残留物后，将组织在预定温度下在抗炎剂，抗血栓剂，酒精和水的第三溶液中浸泡，或依次在抗炎剂，酒精和水溶液中浸泡 ，然后在抗血栓剂，酒精和水溶液中储存。

    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
    9.
    发明授权
    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 有权
    治疗由宿主细胞重建为生物体组织的植入物的胶原结缔组织的方法

    公开(公告)号：US07687230B2

    公开(公告)日：2010-03-30

    申请号：US11345769

    申请日：2006-01-19

    申请人： David T. Cheung

    发明人： David T. Cheung

    IPC分类号： A61F2/04 ,  A61F2/08

    CPC分类号： A01N1/02 ,  A01N1/0226 ,  A61K38/39 ,  A61L27/3604 ,  A61L27/3687

    摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.

    摘要翻译： 本发明涉及一种治疗从供体移出的胶原结缔组织的方法，用于植入到受体中，其被宿主细胞重新吸收或重新定植而没有免疫排斥和炎症反应。 从供体中取出后，对组织进行修整，然后将其浸泡在温度范围为4至10摄氏度的冷稳定溶液中。 然后将组织在预定温度下浸入预定量和浓度的聚二醇，盐，过氧化氢和磷酸盐缓冲液第一溶液中并具有足够的离子强度，以使研磨物质解离，使得胶原纤维保持稳定。 然后将组织在预定温度下在醇和水溶液中浸泡足够的时间以除去第一溶液的残余物。 除去残留物后，将组织在预定温度下在抗炎剂，抗血栓剂，酒精和水的第三溶液中浸泡，或依次在抗炎剂，酒精和水溶液中浸泡 ，然后在抗血栓剂，酒精和水溶液中储存。

    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
    10.
    发明授权
    Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue 失效

    公开(公告)号：US07008763B2

    公开(公告)日：2006-03-07

    申请号：US10253017

    申请日：2002-09-23

    申请人： David T. Cheung

    发明人： David T. Cheung

    IPC分类号： A61F2/04 ,  A61F2/08

    CPC分类号： A01N1/02 ,  A01N1/0226 ,  A61K38/39 ,  A61L27/3604 ,  A61L27/3687

    摘要： The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor, the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored.