公开(公告)号：US09636656B2

公开(公告)日：2017-05-02

申请号：US14362888

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Mark Humayun ,  Clinton J. Regan ,  Azita Emami

IPC: A61K41/00 ,  A61K49/00 ,  B01J19/12 ,  A61K9/00 ,  A61K47/48 ,  A61N5/06 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.

公开(公告)号：US20140311890A1

公开(公告)日：2014-10-23

申请号：US14362887

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Clinton J. Regan

IPC: B01J19/12 ,  C07D209/20 ,  C07D209/12 ,  C07C59/66

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: A photoacid compound having a light absorbing moiety attaching a payload moiety through a linker, in which the linker comprises a geminal dialkyl linked to a carbonyl group attaching the payload moiety, and the linker is configured to present the carbonyl oxygen for reaction with a hydroxyl group presented on the light absorbing moiety in ortho position to the linker.

Abstract translation: 具有光吸收部分的光酸化合物，其通过接头连接有效载荷部分，其中连接体包含与连接有效载荷部分的羰基连接的偕二烷基，连接体被配置为呈现羰基氧以与羟基反应 呈现在与接头相邻的光吸收部分上。

公开(公告)号：US20140308208A1

公开(公告)日：2014-10-16

申请号：US14362888

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Mark Humayun ,  Clinton J. Regan ,  Azita Emami-Neyestanak

IPC: A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61N5/06

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.

Abstract translation: 描述了相关的装置，组合物和系统，其中将笼式化合物施用于生物环境，笼式化合物用长波长吸收剂笼养，长波长为大于或等于750nm的波长; 并照射生物环境以用900-1100nm波长的光激发长波长吸收剂，从而分解化合物。