公开(公告)号：US09701704B2

公开(公告)日：2017-07-11

申请号：US15074545

申请日：2016-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Pablo E. Guzman ,  Tonia S. Ahmed ,  T. Patrick Montgomery

IPC: C07F15/00 ,  B01J31/28 ,  C07C67/30 ,  C07D313/00 ,  C07C67/475 ,  B01J31/12

CPC classification number: C07F15/0046 ,  B01J31/122 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C67/293 ,  C07C67/30 ,  C07C67/333 ,  C07C67/475 ,  C07C2601/10 ,  C07D313/00 ,  C08F2500/25 ,  C08G61/08 ,  C08G2261/3322 ,  C08G2261/418 ,  C07C69/74 ,  C07C69/16 ,  C07C69/78 ,  C07C69/76

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

公开(公告)号：US11407726B2

公开(公告)日：2022-08-09

申请号：US16770153

申请日：2018-12-04

Applicant: California Institute of Technology

Inventor： Tonia S. Ahmed ,  T. Patrick Montgomery ,  Robert H. Grubbs

IPC: C07D313/00 ,  B01J31/22

Abstract: This invention relates generally to the synthesis of E-macrocycles using stereoretentive ruthenium olefin metathesis catalysts supported by dithioiate ligands. Macrocycles were generated with excellent selectivity (>99% E) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield) from diene starting materials bearing two E-olefins or bearing one E-olefin and one terminal olefin, A variety of rings were constructed, ranging from 12- to 18-membered macrocycles, including the antibiotic recifeiolide. The invention has utility in the fields of organometallics and organic synthesis.

公开(公告)号：US10857530B2

公开(公告)日：2020-12-08

申请号：US16060466

申请日：2016-12-09

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. Johns ,  T. Patrick Montgomery ,  Tonia S. Ahmed ,  Robert H. Grubbs ,  Richard L. Pederson

IPC: B01J31/22 ,  C07C6/06 ,  C07C6/04

Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.