公开(公告)号：US09127173B2

公开(公告)日：2015-09-08

申请号：US13940693

申请日：2013-07-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

IPC: A01N25/34 ,  C09D5/14 ,  D06M16/00 ,  A01N33/12 ,  C08G73/02 ,  C09D5/16 ,  C09D179/02

CPC classification number: C09D5/14 ,  A01N33/12 ,  C08G73/0206 ,  C08G73/0226 ,  C09D5/1637 ,  C09D179/02 ,  D06M16/00 ,  Y10T428/31721 ,  Y10T428/31725 ,  A01N25/34 ,  A01N2300/00

Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. in one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.

Abstract translation: 本公开提供了适合于在基底上制备涂层的方法和材料。 涂层包含季胺基，因此赋予基底抗菌性能。 在一个实施方案中，例如，提供了包含丙烯和乙烯重复单元的含季铵的聚合物涂层。

公开(公告)号：US09701704B2

公开(公告)日：2017-07-11

申请号：US15074545

申请日：2016-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Pablo E. Guzman ,  Tonia S. Ahmed ,  T. Patrick Montgomery

IPC: C07F15/00 ,  B01J31/28 ,  C07C67/30 ,  C07D313/00 ,  C07C67/475 ,  B01J31/12

CPC classification number: C07F15/0046 ,  B01J31/122 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C67/293 ,  C07C67/30 ,  C07C67/333 ,  C07C67/475 ,  C07C2601/10 ,  C07D313/00 ,  C08F2500/25 ,  C08G61/08 ,  C08G2261/3322 ,  C08G2261/418 ,  C07C69/74 ,  C07C69/16 ,  C07C69/78 ,  C07C69/76

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

公开(公告)号：US20130149351A1

公开(公告)日：2013-06-13

申请号：US13708830

申请日：2012-12-07

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Paresma Patel ,  Mark Humayun ,  Kenrick Kuwahara ,  Victoria A. Piunova ,  Michael Janusz Koss ,  Yi Zhang

IPC: A61K9/00 ,  C12N5/071 ,  C08G63/91

CPC classification number: A61K9/00 ,  C08G63/912 ,  C08J7/18 ,  C08L67/04 ,  C12N5/0068 ,  C12N5/0621 ,  C12N2533/40 ,  C12N2533/50 ,  Y10T428/31725

Abstract: The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss.

Abstract translation: 本发明提供用于生长RPE细胞的支架，其包含两种或更多种可生物降解的聚合物。 本发明还提供了用于产生用于培养RPE细胞的支架的方法。 另外，本发明提供了用于支持RPE细胞生长的RGD肽连接的聚合物支架。 本发明提供使用本文生产的支架培养RPE细胞的方法。 本发明还提供了通过施用本文生产的RPE细胞附着的RGD肽连接的聚合物支架来治疗视力丧失的方法。 本发明还提供了用于治疗视力丧失的试剂盒。