公开(公告)号：US11224655B2

公开(公告)日：2022-01-18

申请号：US16431605

申请日：2019-06-04

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall Leedy Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K9/107 ,  A61K47/69 ,  A61B17/22 ,  A61K31/663 ,  A61K47/24 ,  A61N7/00

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US11642410B2

公开(公告)日：2023-05-09

申请号：US17544630

申请日：2021-12-07

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K9/107 ,  A61K47/69 ,  A61B17/22 ,  A61K31/663 ,  A61K47/24 ,  A61N7/00

CPC分类号： A61K41/0028 ,  A61B17/2202 ,  A61B17/22004 ,  A61B17/22022 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/663 ,  A61K41/0033 ,  A61K47/24 ,  A61K47/6911 ,  A61N7/00 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61N2007/0039

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US20190282695A1

公开(公告)日：2019-09-19

申请号：US16431605

申请日：2019-06-04

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall Leedy Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61B17/22 ,  A61K47/69 ,  A61N7/00 ,  A61K9/00 ,  A61K9/107 ,  A61K31/663 ,  A61K47/24

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US20220088198A1

公开(公告)日：2022-03-24

申请号：US17544630

申请日：2021-12-07

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K9/107 ,  A61K47/69 ,  A61B17/22 ,  A61K31/663 ,  A61K47/24 ,  A61N7/00

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US10357565B2

公开(公告)日：2019-07-23

申请号：US16154677

申请日：2018-10-08

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61B17/22 ,  A61K47/24 ,  A61K31/663 ,  A61K9/00 ,  A61K9/107 ,  A61N7/00 ,  A61K47/69

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US10149906B2

公开(公告)日：2018-12-11

申请号：US15199710

申请日：2016-06-30

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61B17/22 ,  A61K47/24 ,  A61N7/00 ,  A61K9/107 ,  A61K31/663 ,  A61K47/69

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US20190038749A1

公开(公告)日：2019-02-07

申请号：US16154677

申请日：2018-10-08

申请人： California Institute of Technology ,  The Regents of the University of California

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61B17/22 ,  A61K47/24 ,  A61K31/663

CPC分类号： A61K41/0028 ,  A61B17/22004 ,  A61B17/2202 ,  A61B17/22022 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/663 ,  A61K41/0033 ,  A61K47/24 ,  A61K47/6911 ,  A61N7/00 ,  A61N2007/0039

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US20160367669A1

公开(公告)日：2016-12-22

申请号：US15199710

申请日：2016-06-30

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Robert H. Grubbs ,  Marshall L. Stoller ,  Hoyong Chung ,  Alissa M. Fitzgerald ,  Thomas W. Kenny ,  Renee M. Thomas

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61B17/22 ,  A61K47/24 ,  A61N7/00 ,  A61K9/107 ,  A61K31/663

CPC分类号： A61K41/0028 ,  A61B17/22004 ,  A61B17/2202 ,  A61B17/22022 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/663 ,  A61K41/0033 ,  A61K47/24 ,  A61K47/6911 ,  A61N7/00 ,  A61N2007/0039

摘要： This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

公开(公告)号：US09421164B2

公开(公告)日：2016-08-23

申请号：US14254183

申请日：2014-04-16

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Hoyong Chung ,  Robert H. Grubbs ,  Daniel M. Schwartz

IPC分类号： A61K9/00 ,  A61L24/00 ,  A61L24/06

CPC分类号： A61K9/0048 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/402 ,  C08L33/26

摘要： The present inventions are directed to novel aqueous compositions comprising a copolymer having water-soluble units and pendant catechols, said composition adapted for use on mammalian tissue and having a lower critical solubility temperature (LCST) of less than a physiological temperature, and their use, for example, in removing foreign particles from tissue surfaces, including ocular surfaces.

摘要翻译： 本发明涉及新型含水组合物，其包含具有水溶性单元和侧基邻苯二酚的共聚物，所述组合物适用于哺乳动物组织并且具有小于生理温度的较低临界溶解度温度（LCST） 例如，从包括眼表面的组织表面去除异物。