公开(公告)号：US11135059B2

公开(公告)日：2021-10-05

申请号：US16802353

申请日：2020-02-26

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC: A61F2/24

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US10695173B2

公开(公告)日：2020-06-30

申请号：US16460313

申请日：2019-07-02

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Tal Reich

IPC: A61F2/24 ,  A61F2/848

Abstract: An apparatus for use with a prosthetic heart valve at a native heart valve comprises an adjustable-lumen prosthetic valve support. In a delivery state, the prosthetic valve support is transluminally deliverable to the heart. The prosthetic valve support is transitionable, within the heart, into an implantation state for implantation at the native valve. In the implantation state, the prosthetic valve support has an inner edge that defines a lumen through the prosthetic valve support, the lumen having a first diameter. After the prosthetic valve support is implanted at the native valve, the prosthetic valve support is transitionable into an enlarged state in which the lumen has a second diameter that is greater than the first diameter. In the enlarged state, the prosthetic valve support is configured to support, at the native valve, the prosthetic heart valve within the lumen.

公开(公告)号：US20210393402A1

公开(公告)日：2021-12-23

申请号：US17466785

申请日：2021-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC: A61F2/24

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US10376361B2

公开(公告)日：2019-08-13

申请号：US16045059

申请日：2018-07-25

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Yuval Zipory

IPC: A61F2/24 ,  A61F2/848

Abstract: Apparatus is provided for use with a native valve of a heart of a subject. The apparatus includes: (1) an annular upstream support portion, comprising an expandable first frame, the upstream support portion configured to be placed against an upstream surface of the native valve; (2) a flexible polyester connector; and (3) an anchoring element, flexibly coupled to the upstream support portion by the connector, and configured to anchor the upstream support portion to the native valve by engaging tissue of the native valve.

公开(公告)号：US10245143B2

公开(公告)日：2019-04-02

申请号：US15213791

申请日：2016-07-19

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Yuval Zipory ,  Tal Reich ,  Meir Kutzik ,  Rotem Neeman

IPC: A61F2/24 ,  A61F2/848

Abstract: Apparatus for use at a native heart valve of a subject is described. For some applications, the apparatus comprises a prosthetic valve support, configured (a) to be implanted at the native valve, (b) to facilitate, at a first period, implantation at the native valve of a first prosthetic valve, and (c) to facilitate, at a second period, implantation at the native valve of a second prosthetic valve. Other embodiments are also described.

公开(公告)号：US10226341B2

公开(公告)日：2019-03-12

申请号：US15197069

申请日：2016-06-29

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Yuval Zipory ,  Tal Reich ,  Meir Kutzik ,  Rotem Neeman

IPC: A61F2/24 ,  A61F2/848

Abstract: For some applications, apparatus is provided for facilitating implantation of a prosthetic valve at a native heart valve of a subject, the apparatus comprising a prosthetic valve support, the prosthetic valve support (a) being configured to be transluminally-deliverable to the native valve and to be deployable at the native valve, and (b) comprising one or more tissue-engaging elements, configured to couple the prosthetic valve support to leaflets of the native valve without eliminating check valve functionality of the native valve. Other embodiments are also described.