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公开(公告)号：US20220304804A1
公开(公告)日：2022-09-29
申请号：US17841912
申请日：2022-06-16
申请人： CARDIOVALVE LTD.
发明人： Tal HAMMER , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
IPC分类号： A61F2/24
摘要： A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.
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公开(公告)号：US11135059B2
公开(公告)日：2021-10-05
申请号：US16802353
申请日：2020-02-26
申请人： CARDIOVALVE LTD.
发明人： Tal Hammer , Yuval Zipory , Tal Reich , Yaron Herman , Gil Hacohen , Eran Miller , Rotem Neeman , Natalia Kruglova
IPC分类号： A61F2/24
摘要： Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.
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公开(公告)号：US11701225B2
公开(公告)日：2023-07-18
申请号：US16746489
申请日：2020-01-17
申请人： CARDIOVALVE LTD.
发明人： Tal Hammer , Meni Iamberger , Yuval Zipory , Michael Albitov , Tal Reich , Ilia Hariton
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
摘要： Apparatus includes a delivery tool and a prosthetic valve, the prosthetic valve includes a first frame, and a second frame coupled to the first frame. The delivery tool includes a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.
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公开(公告)号：US12053380B2
公开(公告)日：2024-08-06
申请号：US17841912
申请日：2022-06-16
申请人： CARDIOVALVE LTD.
发明人： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
摘要： A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.
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公开(公告)号：US11872130B2
公开(公告)日：2024-01-16
申请号：US16656790
申请日：2019-10-18
申请人： CARDIOVALVE LTD.
发明人： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
摘要： A prosthetic heart valve implant is provided including a frame shaped so as to define upstream and downstream openings at upstream and downstream ends of the frame, respectively, when the implant is in an expanded state for implantation at a heart native valve. A sheet is coupled to the frame. When the implant is in the expanded state, the frame is shaped so as to define the following longitudinal portions arranged along a central longitudinal axis of the prosthetic heart valve implant: a substantially cylindrical mid portion having a diameter greater than respective diameters of the upstream and the downstream ends of the frame; an upstream portion, extending upstream and radially inward from the mid portion; and a downstream portion, extending downstream and radially inward from the mid portion. Other embodiments are also described.
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公开(公告)号：US20210393402A1
公开(公告)日：2021-12-23
申请号：US17466785
申请日：2021-09-03
申请人： CARDIOVALVE LTD.
发明人： Tal HAMMER , Yuval Zipory , Tal Reich , Yaron Herman , Gil Hacohen , Eran Miller , Rotem Neeman , Natalia Kruglova
IPC分类号： A61F2/24
摘要： Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.
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公开(公告)号：US10524910B2
公开(公告)日：2020-01-07
申请号：US15329920
申请日：2015-07-30
申请人： CARDIOVALVE LTD.
发明人： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
摘要： A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.
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公开(公告)号：US10376361B2
公开(公告)日：2019-08-13
申请号：US16045059
申请日：2018-07-25
申请人： CARDIOVALVE LTD.
发明人： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory
摘要： Apparatus is provided for use with a native valve of a heart of a subject. The apparatus includes: (1) an annular upstream support portion, comprising an expandable first frame, the upstream support portion configured to be placed against an upstream surface of the native valve; (2) a flexible polyester connector; and (3) an anchoring element, flexibly coupled to the upstream support portion by the connector, and configured to anchor the upstream support portion to the native valve by engaging tissue of the native valve.
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公开(公告)号：US10245143B2
公开(公告)日：2019-04-02
申请号：US15213791
申请日：2016-07-19
申请人： CARDIOVALVE LTD.
发明人： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
摘要： Apparatus for use at a native heart valve of a subject is described. For some applications, the apparatus comprises a prosthetic valve support, configured (a) to be implanted at the native valve, (b) to facilitate, at a first period, implantation at the native valve of a first prosthetic valve, and (c) to facilitate, at a second period, implantation at the native valve of a second prosthetic valve. Other embodiments are also described.
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公开(公告)号：US10226341B2
公开(公告)日：2019-03-12
申请号：US15197069
申请日：2016-06-29
申请人： CARDIOVALVE LTD.
发明人： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
摘要： For some applications, apparatus is provided for facilitating implantation of a prosthetic valve at a native heart valve of a subject, the apparatus comprising a prosthetic valve support, the prosthetic valve support (a) being configured to be transluminally-deliverable to the native valve and to be deployable at the native valve, and (b) comprising one or more tissue-engaging elements, configured to couple the prosthetic valve support to leaflets of the native valve without eliminating check valve functionality of the native valve. Other embodiments are also described.
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