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    Prosthetic heart valve with upper skirt
    2.
    发明授权
    Prosthetic heart valve with upper skirt 有权

    公开(公告)号：US11839541B2

    公开(公告)日：2023-12-12

    申请号：US17734472

    申请日：2022-05-02

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen

    IPC: A61F2/24

    CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2439 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2220/0016

    Abstract: A prosthetic heart valve includes a valve ring, which includes metal segments, and which is cylindrical when in an expanded state. A valve ring fabric sleeve is coupled to the valve ring. A leaflet frame is disposed within the valve ring. A plurality of prosthetic leaflets are coupled to the leaflet frame. An upper skirt includes an upper skirt fabric, coupled to the valve ring fabric sleeve; and a flexible upper skirt frame, coupled to the upper skirt fabric such that the upper skirt fabric separates a downstream end of the upper skirt frame from an upstream end of the metal segments of the valve ring. When the prosthetic heart valve is in an expanded state, the upper skirt extends radially outward from the valve ring in an upstream direction and is configured to rest against an atrial surface of the heart. Other embodiments are also described.

    METHOD FOR USE AT A HEART VALVE
    3.
    发明申请
    METHOD FOR USE AT A HEART VALVE 有权

    公开(公告)号：US20210361422A1

    公开(公告)日：2021-11-25

    申请号：US17394807

    申请日：2021-08-05

    Applicant: CARDIOVALVE LTD.

    Inventor： Yossi GROSS ,  Gil Hacohen

    IPC: A61F2/24

    Abstract: A method includes advancing apparatus including a core toward a patient's heart valve. The core tapers in a distal direction toward the smallest perimeter of the core. The apparatus includes a first ventricular arm, which is articulatable with respect to a first atrial arm at a first articulation site, and a second ventricular arm, which is articulatable with respect to a second atrial arm at a second articulation site. The articulation sites are adjacent to the smallest perimeter. The tapering of the core defines a minimum nonzero angle of the atrial arms with respect to a central longitudinal axis of the core. The method also includes clamping the first and second leaflets between the respective atrial arms and the respective ventricular arms. Other embodiments are also described.

    IMPLANT FOR HEART VALVE
    4.
    发明申请
    IMPLANT FOR HEART VALVE 有权

    公开(公告)号：US20210330456A1

    公开(公告)日：2021-10-28

    申请号：US17366711

    申请日：2021-07-02

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen ,  Yossi Gross

    IPC: A61F2/24

    Abstract: Implantable first atrial and ventricular arms are articulatable at a first articulation site to clamp a first heart valve leaflet. A first elongate transitioning member is (a) connected at a fixed connection point at a portion of the first ventricular arm farthest from the first articulation site, (b) has a portion that faces an opposite surface of the first ventricular arm, and (c) is controllable to move the first ventricular arm. Implantable second atrial and ventricular arms are articulatable at a second articulation site to clamp a second leaflet. A second elongate transitioning member is (a) connected at a fixed connection point at a portion of the second ventricular arm farthest from the second articulation site, (b) has a portion that faces an opposite surface of the second ventricular arm, and (c) is controllable to move the second ventricular arm. Other embodiments are also described.

    Prosthetic valve and upstream support therefor
    5.
    发明授权
    Prosthetic valve and upstream support therefor 有权

    公开(公告)号：US11135059B2

    公开(公告)日：2021-10-05

    申请号：US16802353

    申请日：2020-02-26

    Applicant: CARDIOVALVE LTD.

    Inventor： Tal Hammer ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

    IPC: A61F2/24

    Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

    Implant for heart valve
    6.
    发明授权
    Implant for heart valve 有权

    公开(公告)号：US11517436B2

    公开(公告)日：2022-12-06

    申请号：US16888210

    申请日：2020-05-29

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen

    IPC: A61F2/24 ,  A61B17/122 ,  A61B17/00 ,  A61F2/848

    Abstract: An implant includes a clip and a clip-controller interface. The clip is disposed laterally from a central longitudinal axis of the implant, includes first and second arms articulatably coupled to each other, and sandwiches a leaflet of a heart valve between the first and second arms by articulation between the first and second arms, such that the second arm is disposed laterally from the first arm. The clip-controller interface is reversibly coupled to a clip controller of a delivery tool, and includes first and second portions. The first portion is linearly slidable by the clip controller. The second portion is articulatably coupled to the first portion and to the second arm, such that linear sliding of the first portion causes the second portion to (i) articulate with respect to the first portion, and (ii) push the second arm to articulate toward the axis. Other embodiments are also described.

    Prosthetic heart valve with upper and lower skirts
    7.
    发明授权
    Prosthetic heart valve with upper and lower skirts 有权

    公开(公告)号：US11141268B2

    公开(公告)日：2021-10-12

    申请号：US16811732

    申请日：2020-03-06

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen

    IPC: A61F2/24

    Abstract: A prosthetic valve structure, for use at a native atrioventricular heart valve, includes a frame, prosthetic leaflets, an upper skirt, and a lower skirt. The frame circumscribes a longitudinal axis of the structure. The leaflets are configured to facilitate upstream-to-downstream bloodflow through the structure. The upper skirt has an upstream perimeter. The lower skirt is downstream of the upper skirt, and has a downstream perimeter. The upper skirt extends away from the lower skirt, in an upstream direction and radially outward toward the upstream perimeter. The lower skirt extends away from the upper skirt, in a downstream direction and radially outward toward the downstream perimeter. A downstream portion of the frame is disposed downstream of at least part of the downstream perimeter of the lower skirt.

    Techniques for percutaneous mitral valve replacement and sealing
    8.
    发明授权
    Techniques for percutaneous mitral valve replacement and sealing 有权

    公开(公告)号：US10512456B2

    公开(公告)日：2019-12-24

    申请号：US15691032

    申请日：2017-08-30

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

    IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

    Abstract: A transluminal sheath is advanced transfemorally into a left atrium of a heart of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the atrium, and toward a commissure of the mitral valve. A helix is implanted at the mitral valve by advancing the helix out of the surrounding-sheath and through the commissure into a left ventricle of the subject, such that the helix wraps around at least some chordae tendineae of the mitral valve. A prosthetic valve is collapsed into a collapsed state, and subsequently to implanting the helix and collapsing the prosthetic valve, the prosthetic valve is advanced, in its collapsed state, through the transluminal sheath to the mitral valve. The prosthetic valve is implanted in the mitral valve by expanding it such that the helix facilitates anchoring of the prosthetic valve and sealing of the commissure.

    Method for use at a heart valve
    9.
    发明授权
    Method for use at a heart valve 有权

    公开(公告)号：US12167963B2

    公开(公告)日：2024-12-17

    申请号：US17397235

    申请日：2021-08-09

    Applicant: CARDIOVALVE LTD.

    Inventor： Gil Hacohen

    IPC: A61F2/24 ,  A61B17/04 ,  A61B17/064 ,  A61B17/00

    Abstract: An implant includes a central body and anchoring arms that extend proximally from the implant's downstream end portion and that are movable with respect to an upstream end portion of the implant. The implant is advanced into the heart using a catheter and is implanted at a native atrioventricular valve by positioning: (i) the anchoring arms in the ventricle, (ii) the central body between the native valve's leaflets, and (iii) a distal end of an elongate element into the ventricle. The elongate element is (1) pulled to apply a proximally-directed force to the anchoring arms to move the anchoring arms' distal ends axially with respect to the upstream end portion while the distal ends of the anchoring arms remain radially fixed with respect to a central longitudinal axis of the implant, and (2) removed from the subject's body. Other embodiments are also described.

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