公开(公告)号：US20240415647A1

公开(公告)日：2024-12-19

申请号：US18749731

申请日：2024-06-21

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24 ,  A61F2/82

Abstract: An implant includes a support frame, having a compressed state, and an expanded state in which the support frame defines an opening therethrough, and is dimensioned to be placed against an upstream surface of a native heart valve. The implant includes a valve frame having a compressed state, and an expanded state in which the valve frame defines a lumen therethrough, and including a valve member disposed within the lumen. The valve frame is coupled to the support frame via a flexible sheet such that when the support and valve frames are in their expanded state, the valve frame is not in contact with the support frame. The implant is housed in the catheter for implanting transfemorally, with the valve frame closer to a distal end of the catheter than the support frame is to the distal end of the catheter. Other embodiments are also described.

公开(公告)号：US20220304804A1

公开(公告)日：2022-09-29

申请号：US17841912

申请日：2022-06-16

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24

Abstract: A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.

公开(公告)号：US20200046496A1

公开(公告)日：2020-02-13

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yaron HERMAN ,  Yuval ZIPORY ,  Eran HOFFER ,  Michael ALBITOV ,  Natalia KRUGLOVA ,  Tal REICH ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US20210393402A1

公开(公告)日：2021-12-23

申请号：US17466785

申请日：2021-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC: A61F2/24

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US20240058123A1

公开(公告)日：2024-02-22

申请号：US18385643

申请日：2023-10-31

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval ZIPORY ,  Tal REICH ,  Yaron HERMAN ,  Gil HACOHEN ,  Eran MILLER ,  Rotem NEEMAN ,  Natalia KRUGLOVA

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2436 ,  A61F2/2418 ,  A61F2/2409 ,  A61F2220/0075 ,  A61F2250/0098 ,  A61F2220/0025 ,  A61F2220/0016 ,  A61F2210/0076

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US20220175526A1

公开(公告)日：2022-06-09

申请号：US17399594

申请日：2021-08-11

Applicant: CARDIOVALVE LTD.

Inventor： Michael ALBITOV ,  Maxim KARALNIK ,  Meni IAMBERGER ,  Ilia HARITON ,  Tal HAMMER

IPC: A61F2/24 ,  A61F2/95

Abstract: A delivery tool including a shaft and a proximal capsule and a distal capsule is dimensioned for percutaneous delivery to the heart. An open end of the proximal capsule faces the open end of the distal capsule. The capsules are coupled to the shaft in a manner that allows axial movement of the capsule with respect to the shaft. A prosthetic heart valve includes a tubular portion that defines a lumen and prosthetic leaflets disposed within the lumen. The prosthetic heart valve is restrainable in a compressed state by the delivery tool, such that a downstream end of the tubular portion is disposed within the distal capsule. The distal capsule is shaped so as to define an opening for visualizing ensheathing of at least a portion of the downstream end of the tubular portion within the distal capsule. Other embodiments are also described.

公开(公告)号：US20200146824A1

公开(公告)日：2020-05-14

申请号：US16746489

申请日：2020-01-17

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Tal REICH ,  Ilia HARITON

IPC: A61F2/24

Abstract: Embodiments of the present disclosure provide an apparatus comprising a delivery tool and a prosthetic valve, the prosthetic valve comprising a first frame, and a second frame coupled to the first frame. The delivery tool comprises a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.