公开(公告)号：US20250000847A1

公开(公告)日：2025-01-02

申请号：US18687441

申请日：2022-08-31

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Paul J. Tesar ,  Benjamin L.L. Clayton

IPC: A61K31/415 ,  A61K31/167 ,  A61K31/4192 ,  A61P25/00

Abstract: The invention described herein provides methods and reagents for treating diseases or conditions associated with reactive astrocytes using HD AC inhibitors, such as HDAC3-specific inhibitors.

公开(公告)号：US20240360406A1

公开(公告)日：2024-10-31

申请号：US18687438

申请日：2022-08-31

Applicant: Case Western Reserve University

Inventor： Paul J. Tesar ,  Benjamin L.L. Clayton

IPC: C12N5/00 ,  C12N5/079

CPC classification number: C12N5/0037 ,  C12N5/0622 ,  C12N2500/32 ,  C12N2500/99 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/2306 ,  C12N2501/25

Abstract: The invention described herein provides compositions and methods to maintain astrocytes in resting, enrichment and/or maturation, or activation states so that potential therapeutic agents treating diseases or conditions associated with reactive astrocytes can be identified.