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1.发明公开公开(公告)号：US20230233848A1
公开(公告)日：2023-07-27
申请号：US18194896
申请日：2023-04-03
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Kevin L. Kilgore , Jesse S. Wainright , Niloy Bhadra
CPC classification number: A61N1/20 , A61N1/0551
Abstract: Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering/communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering/communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.
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公开(公告)号：US11444306B2
公开(公告)日：2022-09-13
申请号：US17099096
申请日：2020-11-16
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Jesse S. Wainright , Gary E. Wnek , Enoch A. Nagelli , Robert Savinell
Abstract: A composite membrane for use in flow batteries is contemplated. The membrane comprises a hydrogel, such as poly(vinyl alcohol), applied to a polymeric microporous film substrate. This composite is interposed between two half cells of a flow battery. The resulting membrane and system, as well as corresponding methods for making the membrane and making and operating the system itself, provide unexpectedly good performance at a significant cost advantage over currently known systems.
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3.发明申请公开(公告)号：US20200289817A1
公开(公告)日：2020-09-17
申请号：US16820035
申请日：2020-03-16
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Kevin L. Kilgore , Jesse S. Wainright , Niloy Bhadra
Abstract: Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering/communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering/communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.
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公开(公告)号：US11865342B2
公开(公告)日：2024-01-09
申请号：US17890327
申请日：2022-08-18
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Jesse S. Wainright , Niloy Bhadra , Kevin L. Kilgore
CPC classification number: A61N1/36071 , A61N1/048 , A61N1/0456 , A61N1/0556 , A61N1/20
Abstract: Slurry electrodes can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.
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Patent Agency Ranking
公开(公告)号：US11191974B2
公开(公告)日：2021-12-07
申请号：US16614951
申请日：2018-05-24
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Jesse S. Wainright , Kevin L. Kilgore , Narendra Bhadra , Niloy Bhadra
Abstract: A capacity-expanding separated interface nerve electrode (SINE) can be used to deliver a nerve conduction block to one or more nerves. The SINE can include a source electrode coupled to a waveform generator. The source electrode can deliver an electrical neuromodulation signal (e.g., a direct current (DC) signal) to an ionically conductive medium. The SINE can also include a vessel holding the ionically conductive medium, which can include a material that facilitates a transformation of the electrical neuromodulation signal to an ionic neuromodulation signal with a high charge capacity. The SINE can also include a nerve interface that can deliver the ionic neuromodulation signal to a nerve. The SINE can be used in combination with a return electrode that is also coupled to the waveform generator.
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公开(公告)号：US12246174B2
公开(公告)日：2025-03-11
申请号：US18194896
申请日：2023-04-03
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Kevin L. Kilgore , Jesse S. Wainright , Niloy Bhadra
Abstract: Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering/communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering/communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.
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公开(公告)号：US11617884B2
公开(公告)日：2023-04-04
申请号：US16820035
申请日：2020-03-16
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Kevin L. Kilgore , Jesse S. Wainright , Niloy Bhadra
Abstract: Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering/communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering/communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.
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公开(公告)号：US11426585B2
公开(公告)日：2022-08-30
申请号：US16957808
申请日：2018-12-28
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Jesse S. Wainright , Niloy Bhadra , Kevin L. Kilgore
Abstract: The present disclose relates to slurry electrodes that can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.
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公开(公告)号：US20200179710A1
公开(公告)日：2020-06-11
申请号：US16614951
申请日：2018-05-24
Applicant: Case Western Reserve University
Inventor： Tina L. Vrabec , Jesse S. Wainright , Kevin L. Kilgore , Narendra Bhadra , Niloy Bhadra
Abstract: The present disclosure relates to a capacity-expanding separated interface nerve electrode (SINE), which can be used to deliver a nerve conduction block to one or more nerves. The SINE can include a source electrode coupled to a waveform generator. The sour electrode can deliver an electrical neuromodulation signal (e.g., a direct current (DC) signal) to an ionically conductive medium. The SINE can also include a vessel holding the ionically conductive medium, which can include a material that facilitates a transformation of the electrical neuromodulation signal to an ionic neuromodulation signal with a high charge capacity. The SINE can also include a nerve interface that can deliver the ionic neuromodulation signal to a nerve. The SINE can be used in combination with a return electrode that is also coupled to the waveform generator.
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