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公开(公告)号：US11426420B2
公开(公告)日：2022-08-30
申请号：US16603544
申请日：2018-04-09
发明人： Sanford Markowitz , Won Jin Ho , Yiyuan Yuan , Mukesh Jain , Mohamed Sabeh , Joseph Ready , Noelle Williams
IPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
摘要： A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
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公开(公告)号：US11718589B2
公开(公告)日：2023-08-08
申请号：US16484045
申请日：2018-02-06
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04 , A61K45/06 , A61K31/4164
CPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K31/4164 , A61K45/06
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20230322684A1
公开(公告)日：2023-10-12
申请号：US18207777
申请日：2023-06-09
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
CPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K45/06
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20200095206A1
公开(公告)日：2020-03-26
申请号：US16484045
申请日：2018-02-06
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20230165883A1
公开(公告)日：2023-06-01
申请号：US17893777
申请日：2022-08-23
发明人： Sanford Markowitz , Won Jin Ho , Yiyuan Yuan , Mukesh Jain , Mohamad Sabeh , Joseph Ready , Noelle Williams
IPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
CPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
摘要： A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
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公开(公告)号：US20200030348A1
公开(公告)日：2020-01-30
申请号：US16603544
申请日：2018-04-09
发明人： Sanford Markowitz , Won Jin Ho , Yiyuan Yuan , Mukesh Jain , Mohamed Sabeh , Joseph Ready , Noelle Williams
IPC分类号： A61K31/704 , A61K31/7048 , A61K31/4365 , C07K16/32 , A61K31/519 , A61K31/437 , A61K31/4355 , A61K31/5377 , A61K31/496 , A61P9/00
摘要： A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
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