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公开(公告)号：US11357816B2
公开(公告)日：2022-06-14
申请号：US17252573
申请日：2019-06-17
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE , ECOLE NORMALE SUPERIEURE , COLLEGE DE FRANCE
发明人： Jean-Maurice Mallet , Solange Lavielle , Rodrigue Marquant , Alain Prochiantz , Ariel Di Nardo , Damien Testa
摘要： The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.
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公开(公告)号：US20190247461A1
公开(公告)日：2019-08-15
申请号：US15761702
申请日：2016-09-23
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , COLLEGE DE FRANCE , SORBONNE UNIVERSITE
发明人： Alain Prochiantz
摘要： The present invention relates to the use of a homeoprotein or a recombinant vector encoding said protein for treating or preventing DNA damage and/or cellular aging. In particular, the invention concerns the use of Engrailed for the treatment of Parkinson disease.
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3.发明授权公开(公告)号：US10100307B2
公开(公告)日：2018-10-16
申请号：US15520926
申请日：2015-10-30
申请人： Centre National de la Recherche Scientifique , College de France , Institut National de la Sante et de la Recherche Medicale (INSERM) , Sorbonne Universite
发明人： Alain Prochiantz , Julia Fuchs , Rajiv Joshi , François Xavier Blaudin De The , Hocine Rekaik , Olivia Massiani-Beaudoin
IPC分类号： C12N15/113 , C12Q1/68 , C12N15/63 , C12Q1/25
摘要： The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.
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公开(公告)号：US20210379144A1
公开(公告)日：2021-12-09
申请号：US17349746
申请日：2021-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , COLLEGE DE FRANCE , SORBONNE UNIVERSITE
发明人： Alain Prochiantz
摘要： The present disclosure relates to the use of a homeoprotein or a recombinant vector encoding said protein for treating or preventing DNA damage and/or cellular aging. In particular, the invention concerns the use of Engrailed for the treatment of Parkinson disease.
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5.发明授权公开(公告)号：US09868783B2
公开(公告)日：2018-01-16
申请号：US14901655
申请日：2014-07-04
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12N15/11 , C12N15/63 , C12N15/861 , C12N15/86 , C12N15/00 , A61K48/00 , C07K16/18 , A61K39/00 , C12N15/113
CPC分类号： C07K16/18 , A61K39/0007 , A61K48/00 , A61K2039/54 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βAPP or of the activity of the Aβ peptide in the choroid plexus.
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6.发明申请公开(公告)号：US20170335320A1
公开(公告)日：2017-11-23
申请号：US15520926
申请日：2015-10-30
申请人： Centre National de la Recherche Scientifique , College de France , Institut National de la Sante et de la Recherche Medicale (INSERM) , Universite Pierre et Marie Curie
发明人： Alain Prochiantz , Julia Fuchs , Rajiv Joshi , François Xavier Blaudin De The , Hocine Rekaik , Olivia Massiani-Beaudoin
IPC分类号： C12N15/113 , C12N15/63 , C12Q1/25 , C12Q1/68
CPC分类号： C12N15/113 , A61K31/7072 , C12N15/63 , C12N2740/00011 , C12Q1/25 , C12Q1/68
摘要： The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.
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7.发明申请INHIBITION OF THE SYNTHESIS OF BETA-APP OR OF THE ACTIVITY OF THE A-BETA PEPTIDE IN THE CHOROID PLEXUS 有权抑制β-APP合成或α-酮霉素在革兰氏阴性菌中的活性的抑制公开(公告)号：US20160159889A1
公开(公告)日：2016-06-09
申请号：US14901655
申请日：2014-07-04
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLEGE DE FRANCE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C07K16/18 , C12N15/113
CPC分类号： C07K16/18 , A61K39/0007 , A61K48/00 , A61K2039/54 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βAPP or of the activity of the Aβ peptide in the choroid plexus.
摘要翻译： 本发明涉及治疗神经退行性疾病，特别是阿尔茨海默氏病，通过抑制APP的合成或A＆Bgr的活性; 脉络丛中的肽。
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公开(公告)号：US10342851B2
公开(公告)日：2019-07-09
申请号：US15923108
申请日：2018-03-16
发明人： Alain Prochiantz , Kenneth Moya , Rajiv Joshi
摘要： The invention relates to the use of an Engrailed protein as a medicament for increasing dopamine synthesis by dopaminergic neurons, in particular in the management of conditions associated with a decrease of dopamine levels without loss of dopaminergic neurons.
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公开(公告)号：US20180271937A1
公开(公告)日：2018-09-27
申请号：US15923108
申请日：2018-03-16
发明人： Alain Prochiantz , Kenneth Moya , Rajiv Joshi
IPC分类号： A61K38/17
CPC分类号： A61K38/1709
摘要： The invention relates to the use of an Engrailed protein as a medicament for increasing dopamine synthesis by dopaminergic neurons, in particular in the management of conditions associated with a decrease of dopamine levels without loss of dopaminergic neurons.
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